List of IBVT related publications


  1. 2023

    1. Ulmer,A.U., Veit,S., Erdemann,F., Freund,A., Loesch,M., Teleki,A., Zeidan,A.A. and Takors,R. (2023) A Two‐Compartment Fermentation System to Quantify Strain‐Specific Interactions in Microbial Co‐Cultures. Bioengineering, 10.
    2. Wild,M., Mast,Y. and Takors,R. (2023) Revisiting Basics of KLa Dependency on Aeration in Bubble Columns: A Is Surprisingly Stable. Chemie Ingenieur Technik, 95, 1–8.
    3. Cordell,W.T., Avolio,G., Takors,R. and Pfleger,B.F. (2023) Milligrams to Kilograms: Making Microbes work at Scale. TIBTEC,
    4. Matamouros,S., Gensch,T., Cerff,M., Sachs,C.C., Abdollahzadeh,I., Hendrick,J., Horst,L., Tenhaef,N., Tenhaef,J., Noack,S., et al. (2023) Growth-Rate Dependency of Ribosome Abundance and Translation Elongation Rate in Corynebacterium Glutamicum Differs from That in Escherichia Coli. Nature Communications, 14.
    5. Minden,S., Aniolek,M., Noorman,H. and Takors,R. (2023) Mimicked Mixing-Induced Heterogeneities of Industrial Stimulate Long-Lasting Adaption Programs in Ethanol-Producing Yeasts. genes, 14.
    6. Mast,Y. and Takors,R. (2023) Transferring Bubble Breakage Models Tailored for Euler-Euler to Euler-Lagrange Simulations. processes, 11, 1–22.
    7. Bendig,T., Ulmer,A., Luzia,L., Müller,S., Sahle,S., Bergmann,F.T., Lösch,M., Erdemann,F., Zeidan,A.A., Mendoza,S.N., et al. (2023) The PH-Dependent Lactose Metabolism of Lactobacillus Delbrueckii Subsp. Bulgaricus: An Integrative View through a Mechanistic Computational Model. J Biotechnol.
    8. Lataster,L., Huber,H.M., Böttcher,C., Föller,S., Takors,R. and Radziwill,G. (2023) Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein P21. Biology, 12.
    9. Pfleger,B.F. and Takors,R. (2023) Recent Progress in the Synthesis of Advanced Biofuel and Bioproducts. Current Opinion in Biotechnology, 80, 1–10.
  2. 2022

    1. Minden,S., Aniolek,M., Hajian,C.S.S., Teleki,A., Zerrer,T., Delvigne,F., van Gulik,W., Deshmukh,A., Noorman,H. and Takors,R. (2022) Monitoring Intracellular Metabolite Dynamics in Saccharomyces Cerevisiae during Industrially Relevant Famine Stimuli. metabolites, 12.
    2. Hildenbrand,J.C., Sprenger,G.A., Teleki,A., Takors,R. and Jendrossek,D. (2022) Polyphosphate Kinases Phosphorylate Thiamine Phosphates. Microbial Physiology,
    3. Rehnert,M. and Takors,R. (2022) FAIR Research Data Management as Community Approach in Bioengineering. Engineering in Life Science, DOI: 10.1002/elsc.202200005.
    4. Müller,T., Schick,S., Beck,J., Sprenger,G. and Takors,R. (2022) Synthetic Mutualism in Engineered E. Coli Mutant Strains as Functional Basis for Microbial Production Consortia. Engineering in Life Science,
    5. Gaugler,L., Mast,Y., Fitschen,J., Hofmann,S., Schlüter,M. and Takors,R. (2022) Scaling-down Biopharmaceutical Production Processes via a Single Multi-Compartment Bioreactor (SMCB). Engineering in life sciences, DOI: 10.1002/elsc.202100161.
    6. Ulmer,A., Erdemann,F., Mueller,S., Loesch,M., Wildt,S., Jensen,M.L., Gaspar,P., Zeidan,A.A. and Takors,R. (2022) Differential Amino Acid Uptake and Depletion In-Cultures and Co-Cultures of Streptococcus Thermophilus and Lactobacillus Delbrueckii Subsp. Bulgaricus in a Novel Semi-Synthetic Medium. microorganisms, 10.
    7. Schmidt,C., Trinkmann,F., Takors,R., Cattaneo,G. and Port,J. (2022) Investigation of Tracer Gas Transport in a New Numerical Model of Lung Acini. Medical & Biological Engineering & Computing.
    8. Minden,S., Aniolek,M., Noorman,H. and Takors,R. (2022) Performing in Spite of Starvation: How Saccharomyces Cerevisiae Maintains Robust Growth When Facing Famine Zones in Industrial Bioreactors. Microbial Biotechnology, 16, 148--168.
  3. 2021

    1. Wijaya,A.W., Ulmer,A., Hundsdorfer,L., Verhagen,N., Teleki,A. and Takors,R. (2021) Compartment‑specific Metabolome Labeling Enables the Identification of Subcellular Fluxes That May Serve as Promising Metabolic Engineering Targets in CHO Cells. Bioprocess and Biosystems Engineering, 10.1007/s00449-021-02628-1.
    2. Perpelea,A., Wijaya,A.W., Martins,L.C., Rippert,D., Klein,M., Angelov,A., Peltonen,K., Teleki,A., Liebl,W., Richard,P., et al. (2021) Towards Valorization of Pectin-Rich Agro-Industrial Residues: Engineering of Saccharomyces Cerevisiae for Co-Fermentation of d-Galacturonic Acid and Glycerol. Metabolic Engineering, 10.1016/j.ymben.2021.10.001.
    3. Ziegler,M., Zieringer,J., Döring,C.-L., Paul,L., Schaal,C. and Takors,R. (2021) Engineering a Robust Escherichia Coli Chassis and Exploitation for Large-Scale Production Process. Metabolic Engineering, 67, 75–87.
    4. Kappelmann,J., Klein,B., Papenfuß,M., Lange,J., Blombach,B., Takors,R., Wiechert,W., Polen,T. and Noack,S. (2021) Comprehensive Analysis of C. Glutamicum Anaplerotic Deletion Mutants Under Defined D-Glucose Conditions. Frontiers in Bioengineering and Biotechnology, 8.
    5. Hermann,M., Teleki,A., Weitz,S., Niess,A., Freund,A., Bengelsdorf,F.R., Dürre,P. and Takors,R. (2021) Identifying and Engineering Bottlenecks of Autotrophic Isobutanol Formation in Recombinant C. Ljungdahlii by Systemic Analysis. Frontiers in Bioengineering and Biotechnology, 9.
    6. Demling,P., Ankenbauer,A., Klein,B., Noack,S., Tiso,T., Takors,R. and Blank,L.M. (2021) Pseudomonas Putida KT2440 Endures Temporary Oxygen Limitations. Biotechnology and Bioengineering, 10.1002/bit.27938.
    7. Schäfer,R.A. and Voß,B. (2021) RNAnue: Efficient Data Analysis for RNA–RNA Interactomics. Nucleic Acids Research, 10.1093/nar/gkab340.
    8. Huang,J. and Voß,B. (2021) Simulation of Folding Kinetics for Aligned RNAs. Genes, 12, 347.
    9. Wijaya,A.W. and Takors,R. (2021) A Transhydrogenase-like Mechanism in CHO Cells Comprising Concerted Reaction and Mitochondrial Shuttling Activities. Biochemical Engineering Journal, 170.
    10. Weitz,S., Hermann,M., Linder,S., Bengelsdorf,F.R., Takors,R. and Dürre,P. (2021) Isobutanol Production by Autotrophic Acetogenic Bacteria. Frontiers in Bioengineering and Biotechnology, 10.3389/fbio.2021.657253.
    11. Ziegler,M., Hägele,L., Gäbele,T. and Takors,R. (2021) CRISPRi Enables Fast Growth Followed by Stable Aerobic Formation in Escherichia Coli without Auxotrophy. Engineering in Life Science, 10.1002/elsc.202100021.
    12. Wijaya,A.W., Verhagen,N., Teleki,A. and Takors,A. (2021) Compartment-Specific 13C Metabolic Flux Analysis Reveals Boosted NADPH Availability Coinciding with Increased Cell-Specific Productivity for IgG1 Producing CHO Cells after MTA Treatment. Engineering in Life Science, 10.1002/elsc.202100057.
    13. Ankenbauer,A., Nithschel,R., Müller,T., Favelli,L., Blombach,B. and Takors,R. (2021) Micro-Aerobic Production of Isobutanol with Engineered Pseudomonas Putida. Engineering in Life Science.
    14. Märkle,P., Maier,L.-K., Maaß,S., Hirschfeld,C., Bartel,J., Becher,D., Voß,B. and Marchfelder,A. (2021) A Small RNA Is Linking CRISPR-Cas and Zinc Transport. Frontiers in Molecular Biosciences, 8.
  4. 2020

    1. Ziegler,M., Zieringer,J. and Takors,R. (2020) Transcriptional Profiling of the Stringent Response Mutant Strain E. Coli SR Reveals Enhanced Robustness to Large-Scale Conditions. microbial biotechnology, 10.1111/1751-7915.13738.
    2. Verhagen,N., Wijaya,A.W., Teleki,A., Fadhlullah,M., Unsöld,A., Schilling,M., Heinrich,C. and Takors,R. (2020) Comparison of L-Tyrosine Containing Dipeptides Reveals ATP Availability for l-Prolyl-l-Tyrosine in CHO. Engineering in Life Science, 10.1002/elsc.202000017.
    3. Zieringer,J., Wild,M. and Takors,R. (2020) Data‐driven in Silico Prediction of Regulation heterogeneity and ATP Demands of Escherichia Coli in Large‐scale Bioreactors. Biotechnol. Bioeng., 118, 265–278.
    4. Verhagen,N., Teleki,A., Heinrich,C., Schilling,M., Unsoeld,A. and Takors,R. (2020) S-Adenosylmethionine and Methylthioadenosine Boost Cellular Productivities of Antibody Forming Chinese Hamster Ovary Cells. Biotechnol. Bioeng., 10.1002/bit.27484.
    5. Müller,F., Rapp,J., Hacker,A.-L., Feith,A., Takors,R. and Blombach,B. (2020) CO2/HCO3- Accelerates Iron Reduction through Phenolic Compounds. mbio.
    6. Feith,A., Schwentner,A., Teleki,A., Favilli,L., Blombach,B. and Takors,R. (2020) Streamlining the Analysis of Dynamic 13C-Labeling for the Metabolic Engineering of Corynebacterium Glutamicum as l-Histidine Production Host. Metabolites, 10.
    7. Verhagen,N., Zieringer,J. and Takors,R. (2020) Methylthioadenosine (MTA) Boosts Cell-Specific Productivities of Chinese Hamster Ovary Cultures: Dosage Effects on Proliferation, Cell Cycle and Gene Expression. FEBS Open Bio, 10, 2791–2804.
    8. Hermann,M., Teleki,A., Weitz,S., Niess,A., Freund,A., Bengelsdorf,F.R. and Takors,R. (2020) Electron Availability in CO2, CO and H2 Mixtures Flux Distribution, Energy Management and product Formation in Clostridium Ljungdahlii. Microbial Biotechnology, 10.1111/1751-7915.13625.
    9. Schäfer,R.A., Lott,S.C., Georg,J., Grüning,B.A., Hess,W.R. and Voß,B. (2020) GLASSGo in Galaxy: High-Throughput, Reproducible and Easy-to-Integrate Prediction of SRNA Homologs. Bioinformatics, 10.1093/bioinformatics/btaa556.
    10. Patil,V., Santos,C.N.S., Ajikumar,P.K., Sarria,S. and Takors,R. (2020) Balancing Glucose and Oxygen Uptake Rates to Enable High Amorpha‐4,11‐diene Production in Escherichia Coli via the Methylerythritol Phosphate Pathway. Biotechnol. Bioeng., 10.1002/bit.27655.
    11. Müller,J., Siemann-Herzberg,M. and Takors,R. (2020) Modeling Cell-Free Protein Synthesis—Approaches And. Frontiers in Bioengineering and Biotechnology,
    12. Kuschel,M. and Takors,R. (2020) Simulated Oxygen and Glucose Gradients as a Prerequisite for predicting Industrial Scale Performance a Priori. Biotechnol. Bioeng., 117, 2760–2770.
    13. Sarkizi Shams Hajian,C., Haringa,C., Noorman,H. and Takors,R. (2020) Predicting By-Product Gradients of Baker’s Yeast at Industrial Scale: A Practical Simulation Approach. Processes, 8.
    14. Graf,M., Haas,T., Teleki,A., Feith,A., Cerff,M., Wiechert,W., Noeh,K., Busche,T., Kalinowski,J. and Takors,R. (2020) Revisiting the Growth Modulon of Corynebacterium Glutamicum Under Glucose Limited Chemostat. Frontiers in Bioengineering and Biotechnology, 10.3389/fbioe.2020.584614.
    15. Ankenbauer,A., Schäfer,R.A., Viegas,S.C., Pobre,V., Voß,B., Arraiano,C.M. and Takors,R. (2020) Pseudomonas Putida KT2440 Is Naturally Endowed to Withstand Industrial-Scale Stress Conditions. Microbial Biotechnology, n/a.
    16. Siebler,F., Lapin,A. and Takors,R. (2020) Synergistically Applying 1D Modeling and CFD for Designing Industrial Scale Bubble Column Syngas Bioreactors. Engineering in Life Science, 10.1002/elsc.201900132.
    17. Alkhnbashi,O.S., Meier,T., Mitrofanov,A., Backofen,R. and Voß,B. (2020) CRISPR-Cas Bioinformatics. Methods, 172, 3–11.
  5. 2019

    1. Graf,M., Haas,T., Müller,F., Buchmann,A., Harm-Betbenbetova,J., Freund,A., Nieß,A., Persicke,M., Kalinowski,J., Blombach,B., et al. (2019) Continuous Adaptive Evolution of a Fast-Growing Corynebacterium Glutamicum Strain Independent of Protocatechuate. Frontiers in Microbiology, 10.3389/fmicb.2019.01648.
    2. Straathof,A.J.J., Wahl,S.A., Benjamin,K.R., Takors,R., Wierckx,N. and Noorman,H.J. (2019) Grand Research Challenges for Sustainable Industrial Biotechnology. Trends in Biotechnology,
    3. Grenz,S., Baumann,P.T., Rückert,C., Nebel,B.A., Siebert,D., Schwentner,A., Eikmanns,B.J., Hauer,B., Kalinowsk, i J., Takors,R., et al. (2019) Exploting Hydrogenophage Pseudoflava for Aerobic Syngas-Based Production of Chemicals. Metabolic Engineering, 55, 220–230.
    4. Nieß,A., Siemann-Herzberg,M. and Takors,R. (2019) Protein Production in Escherichia Coli Guided by the Trade‑off between Intracellular Availability and Energy Cost. Microbial Cell Factories, 18.
    5. Nitschel,R., Ankenbauer,A., Welsch,I., Wirth,N.T., Massner,C., Ahmad,N., McColm,S., Borges,F., Fotheringham,I., Takors,R., et al. (2019) Engineering Pseudomonas Putida KT2440 for the production of Isobutanol. Engineering in Life Science, 20, 148–159.
    6. Niess,A., Siemann-Herzberg,M. and Takors,R. (2019) Protein Production in Escherichia Coli Is Guided by the Trade-off between Intracellular Substrate Availability and Energy Cost. Microbial Cell Factory, 18.
    7. Junghans,L., Teleki,A., Wijaya,A., Becker,M., Schweikert,M. and Takors,R. (2019) From Nutrional Wealth to Autophagy: In Vivo Metabolic Dynamics in the Cytosol, Mitochondrion and Shuttles of IgG Producing CHO Cells. Metabolic Engineering, 54, 145–159.
    8. Becker,M., Junghans,L., Teleki,A., Bechmann,J. and Takors,R. (2019) The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies with Chinese Hamster Ovary Cells. Frontiers in Bioengineering and Biotechnlogy, 7.
    9. Schwentner,A., Feith,A., Münch,E., Stiefelmaier,J., Lauer,I., Favilli,L., Massner,C., Öhrlein,J., Grund,B., Hüser,A., et al. (2019) Modular Systems Metabolic Engineering Enables Balancing of Relevant Pathways for L-Histidine Production with Corynebacterium Glutamicum. Biotechnology for Biofuels, 12.
    10. Haas,T., Graf,M., Nieß,A., Busche,T., Kalinowski,J., Blombach,B. and Takors,T. (2019) Identifying the Growth Modulon of Corynebacterium Glutamicum. Frontiers in Microbiology, 10.
    11. Becker,M., Junghans,L., Teleki,A., Bechmann,J. and Takors,R. (2019) Perfusion Cultures Equire Optimum Respiratory ATP Supply to Maximize Cell‐specific and Volumetric Productivities. Biotechnol. Bioeng., 10.1002/bit.26926.
    12. Pobre,V., Graça-Lopes,G., Saramago,M., Ankenbauer,A., Takors,T., Arraiano,C.M. and Viegas,S.C. (2019) Prediction of Novel Non-Coding RNAs Relevant for the Growth of Pseudomonas Putida in a Bioreactor. Microbiology.
    13. Takors,R. (2019) Biochemical Engineering Provides Mindset, Tools and solutions for the Driving Questions of a Sustainable Future. Engineering in Life Science, 10.1002/elsc.201900150.
    14. Ziegler,M. and Takors,R. (2019) Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis. In: Minimal Cells: Design, Construction, Biotechnological Applications. In Lara,A.R., Gosset Lagarda,G. (eds).
    15. Feith,A., Teleki,A., Graf,M., Favilli,L. and Takors,R. (2019) HILIC-Enabled 13C Metabolomics Strategies: Comparing Quantitative Precision and Spectral Accuracy of QToF High - and QQQ Low-Resolution Mass Spectrometry. Metabolites, 10.3390/metabo9040063.
    16. Siebler,F., Lapin,A., Hermann,M. and Takors,R. (2019) The Impact of CO Gradients on C. Ljungdahlii in a 125 M3 Bubble Column: Mass Transfer, Circulation Time and Lifeline Analysis. Chemical Engineering Science, 207, 410–423.
  6. 2018

    1. Lange,J., Mueller,F., Takors,R. and Blombach,B. Harnessing Novel Chromosomal Integration Loci to Utilize an    Organosolv-Derived Hemicellulose Fraction Forisobutanol Production with    Engineered Corynebacterium Glutamicum. MICROBIAL BIOTECHNOLOGY, 11, 257–263.
    2. Failmezger,J., Scholz,S., Blombach,B. and Siemann-Herzberg,M. (2018) Cell-Free Protein Synthesis From Fast-Growing Vibrio Natriegens. Frontiers in Microbiology, 9.
    3. Takors,R., Kopf,M., Mampel,J., Bluemke,W., Blombach,B., Eikmanns,B., Bengelsdorf,F.R., Weuster‐Botz,D. and Dürre,P. (2018) Using Gas Mixtures of CO, CO2 and H2 as Microbial Substrates: The Do’s and Don’ts of Successful Technology Transfer from Laboratory to Production Scale. Microbial Biotechnology, 11.
    4. Schönberger,B., Schaal,C., Schäfer,R. and Voß,B. (2018) RNA Interactomics: Recent Advances and Remaining Challenges. F1000Research, 7, 1824.
    5. Lott,S.C., Schäfer,R.A., Mann,M., Backofen,R., Hess,W.R., Voß,B. and Georg,J. (2018) GLASSgo - Automated and Reliable Detection of SRNA Homologs from a Single Input Sequence. Frontiers in Genetics, 9.
    6. Lange,J., Münch,E., Müller,J., Busche,T., Kalinowski,J., Takors,R. and Blombach,B. (2018) Deciphering the Adaptation of Corynebacterium Glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis. Genes, 9, 297.
    7. Zieringer,J. and Takors,R. (2018) In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models. Computational and Structural Biotechnology Journal, 16, 246–256.
    8. Graf,M., Zieringer,J., Haas,T., Nieß,A., Blombach,B. and Takors,R. (2018) Physiological Response of Corynebacterium Glutamicum to Increasingly Nutrient-Rich Growth Conditions. Frontiers in Microbiology, 9.
  7. 2017

    1. Niess,A., Failmezger,J., Kuschel,M., Siemann-Herzberg,M. and Takors,R. Experimentally Validated Model Enables Debottlenecking of in Vitro  Protein Synthesis and Identifies a Control Shift under in Vivo  Conditions. ACS SYNTHETIC BIOLOGY, 6, 1913–1921.
    2. Michalowski,A., Siemann-Herzberg,M. and Takors,R. Escherichia Coli HGT: Engineered for High Glucose Throughput Even under    Slowly Growing or Resting Conditions. METABOLIC ENGINEERING, 40, 93–103.
    3. Niess,A., Loeffler,M., Simen,J.D. and Takors,R. Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce  Long-Term Adaptation of E-Coli Cultures in Large-Scale Bioreactors:    Experimental Evidence and Mathematical Model. FRONTIERS IN MICROBIOLOGY, 8.
    4. Simen,J.D., Loeffler,M., Jaeger,G., Schaeferhoff,K., Freund,A., Matthes,J., Mueller,J., Takors,R. and RecogNice-Team Transcriptional Response of Escherichia Coli to Ammonia and Glucose  Fluctuations. MICROBIAL BIOTECHNOLOGY, 10, 858–872.
    5. Delvigne,F., Takors,R., Mudde,R., van Gulik,W. and Noorman,H. Bioprocess Scale-up/down as Integrative Enabling Technology: From Fluid  Mechanics to Systems Biology and Beyond. MICROBIAL BIOTECHNOLOGY, 10, 1267–1274.
    6. Teleki,A., Rahnert,M., Bungart,O., Gann,B., Ochrombel,I. and Takors,R. Robust Identification of Metabolic Control for Microbial L-Methionine  Production Following an Easy-to-Use Puristic Approach. METABOLIC ENGINEERING, 41, 159–172.
    7. Lange,J., Mueller,F., Bernecker,K., Dahmen,N., Takors,R. and Blombach,B. Valorization of Pyrolysis Water: A Biorefinery Side Stream, for    1,2-Propanediol Production with Engineered Corynebacterium Glutamicum. BIOTECHNOLOGY FOR BIOFUELS, 10.
    8. Failmezger,J., Rauter,M., Nitschel,R., Kraml,M. and Siemann-Herzberg,M. Cell-Free Protein Synthesis from Non-Growing, Stressed Escherichia Coli. SCIENTIFIC REPORTS, 7.
    9. Hoffart,E., Grenz,S., Lange,J., Nitschel,R., Mueller,F., Schwentner,A., Feith,A., Lenfers-Luecker,M., Takors,R. and Blombach,B. High Substrate Uptake Rates Empower Vibrio Natriegens as Production Host  for Industrial Biotechnology. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83.
    10. Loeffler,M., Simen,J.D., Mueller,J., Jaeger,G., Laghrami,S., Schaeferhoff,K., Freund,A., Takors,R. and RecogNice-Team Switching between Nitrogen and Glucose Limitation: Unraveling  Transcriptional Dynamics in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 258, 2–12.
    11. Eigenstetter,G. and Takors,R. Dynamic Modeling Reveals a Three-Step Response of Saccharomyces  Cerevisiae to High CO2 Levels Accompanied by Increasing ATP Demands. FEMS YEAST RESEARCH, 17.
    12. Failmezger,J., Ludwig,J., Niess,A. and Siemann-Herzberg,M. Quantifying Ribosome Dynamics in Escherichia Coli Using Fluorescence. FEMS MICROBIOLOGY LETTERS, 364.
    13. Lange,J., Takors,R. and Blombach,B. Zero-Growth Bioprocesses: A Challenge for Microbial Production Strains  and Bioprocess Engineering. ENGINEERING IN LIFE SCIENCES, 17, 27–35.
  8. 2016

    1. Takors,R. and de Lorenzo,V. Editorial Overview: Microbial Systems Biology: Systems Biology Prepares  the Ground for Successful Synthetic Biology. CURRENT OPINION IN MICROBIOLOGY, 33, VIII–X.
    2. Loeffler,M., Simen,J.D., Jaeger,G., Schaeferhoff,K., Freund,A. and Takors,R. Engineering E-Coli for Large-Scale Production - Strategies Considering  ATP Expenses and Transcriptional Responses. METABOLIC ENGINEERING, 38, 73–85.
    3. Junghans,L., Teleki,A., Becker,M. and Takors,R. LC-MS-Based Compartment-Specific Metabolome Analysis in CHO. NEW BIOTECHNOLOGY, 33, S33–S34.
    4. Failmezger,J., Nitschel,R., Sanchez-Kopper,A., Kraml,M. and Siemann-Herzberg,M. Site-Specific Cleavage of Ribosomal RNA in Escherichia Coli-Based  Cell-Free Protein Synthesis Systems. PLoS One, 11.
    5. Wutz,J., Lapin,A., Siebler,F., Schaefer,J.E., Wucherpfennig,T., Berger,M. and Takors,R. Predictability of k(L)a in Stirred Tank Reactors under Multiple  Operating Conditions Using an Euler-Lagrange Approach. ENGINEERING IN LIFE SCIENCES, 16, 633–642.
    6. Pfizenmaier,J., Junghans,L., Teleki,A. and Takors,R. Hyperosmotic Stimulus Study Discloses Benefits in ATP Supply and Reveals  MiRNA/MRNA Targets to Improve Recombinant Protein Production of CHO  Cells. BIOTECHNOLOGY JOURNAL, 11, 1037–1047.
    7. Takors,R. Editorial: How Can We Ensure the Successful Transfer from Lab- to    Large-Scale Production? ENGINEERING IN LIFE SCIENCES, 16, 587.
    8. Sanchez-Kopper,A., Becker,M., Pfizenmaier,J., Kessler,C., Karau,A. and Takors,R. Tracking Dipeptides at Work-Uptake and Intracellular Fate in CHO Culture. AMB EXPRESS, 6.
    9. Lieder,S., Jahn,M., Koepff,J., Mueller,S. and Takors,R. Environmental Stress Speeds up DNA Replication in Pseudomonas Putida in    Chemostat Cultivations. BIOTECHNOLOGY JOURNAL, 11, 155–163.
  9. 2015

    1. Rimbon,J., Sanchez-Kopper,A., Wahl,A. and Takors,R. Monitoring Intracellular Protein Degradation in Antibody-Producing  Chinese Hamster Ovary Cells. ENGINEERING IN LIFE SCIENCES, 15, 499–508.
    2. Henkel,M., Zwick,M., Beuker,J., Willenbacher,J., Baumann,S., Oswald,F., Neumann,A., Siemann-Herzberg,M., Syldatk,C. and Hausmann,R. Teaching Bioprocess Engineering to Undergraduates: Multidisciplinary  Hands-on Training in a One-Week Practical Course. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 43, 189–202.
    3. Pfizenmaier,J., Matuszczyk,J.-C. and Takors,R. Changes in Intracellular ATP-Content of CHO Cells as Response to    Hyperosmolality. BIOTECHNOLOGY PROGRESS, 31, 1212–1216.
    4. Teleki,A., Sanchez-Kopper,A. and Takors,R. Alkaline Conditions in Hydrophilic Interaction Liquid Chromatography for    Intracellular Metabolite Quantification Using Tandem Mass Spectrometry. ANALYTICAL BIOCHEMISTRY, 475, 4–13.
    5. Vallon,T., Simon,O., Rendgen-Heugle,B., Frana,S., Mueckschel,B., Broicher,A., Siemann-Herzberg,M., Pfannenstiel,J., Hauer,B., Huber,A., et al. Applying Systems Biology Tools to Study N-Butanol Degradation in    Pseudomonas Putida KT2440. ENGINEERING IN LIFE SCIENCES, 15, 760–771.
    6. Lieder,S., Nikel,P.I., de Lorenzo,V. and Takors,R. Genome Reduction Boosts Heterologous Gene Expression in Pseudomonas  Putida. MICROBIAL CELL FACTORIES, 14.
    7. Matuszczyk,J.-C., Teleki,A., Pfizenmaier,J. and Takors,R. Compartment-Specific Metabolomics for CHO Reveals That ATP Pools in    Mitochondria Are Much Lower than in Cytosol. BIOTECHNOLOGY JOURNAL, 10, 1639–1650.
  10. 2014

    1. Sudarsan,S., Dethlefsen,S., Blank,L.M., Siemann-Herzberg,M. and Schmid,A. The Functional Structure of Central Carbon Metabolism in Pseudomonas  Putida KT2440. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80, 5292–5303.
    2. Lindner,R., Moosmann,A., Dietrich,A., Boettinger,H., Kontermann,R. and Siemann-Herzberg,M. Process Development of Periplasmatically Produced Single Chain Fragment  Variable against Epidermal Growth Factor Receptor in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 192, 136–145.
    3. Buchholz,J., Graf,M., Freund,A., Busche,T., Kalinowski,J., Blombach,B. and Takors,R. CO2/HCO3 (-) Perturbations of Simulated Large Scale Gradients in a    Scale-down Device Cause Fast Transcriptional Responses in    Corynebacterium Glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 98, 8563–8572.
    4. Buchholz,J., Graf,M., Blombach,B. and Takors,R. Improving the Carbon Balance of Fermentations by Total Carbon Analyses. BIOCHEMICAL ENGINEERING JOURNAL, 90, 162–169.
    5. Gelves,R., Dietrich,A. and Takors,R. Modeling of Gas-Liquid Mass Transfer in a Stirred Tank Bioreactor  Agitated by a Rushton Turbine or a New Pitched Blade Impeller. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 37, 365–375.
    6. Lieder,S., Jahn,M., Seifert,J., von Bergen,M., Mueller,S. and Takors,R. Subpopulation-Proteomics Reveal Growth Rate, but Not Cell Cycling, as a    Major Impact on Protein Composition in Pseudomonas Putida KT2440. AMB EXPRESS, 4.
    7. Schuhmacher,T., Loeffler,M., Hurler,T. and Takors,R. Phosphate Limited Fed-Batch Processes: Impact on Carbon Usage and Energy  Metabolism in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 190, 96–104.
  11. 2013

    1. Buchholz,J., Schwentner,A., Brunnenkan,B., Gabris,C., Grimm,S., Gerstmeir,R., Takors,R., Eikmanns,B.J. and Blombach,B. Platform Engineering of Corynebacterium Glutamicum with Reduced Pyruvate  Dehydrogenase Complex Activity for Improved Production of L-Lysine,    L-Valine, and 2-Ketoisovalerate. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 79, 5566–5575.
    2. Vallon,T., Glemser,M., Malca,S.H., Scheps,D., Schmid,J., Siemann-Herzberg,M., Hauer,B. and Takors,R. Production of 1-Octanol from n-Octane by Pseudomonas Putida KT2440. CHEMIE INGENIEUR TECHNIK, 85, 841–848.
    3. Soellner,S., Rahnert,M., Siemann-Herzberg,M., Takors,R. and Altenbuchner,J. Evolution of Pyruvate Kinase-Deficient Escherichia Coli Mutants Enables  Glycerol-Based Cell Growth and Succinate Production. JOURNAL OF APPLIED MICROBIOLOGY, 115, 1368–1378.
    4. Blombach,B., Buchholz,J., Busche,T., Kalinowski,J. and Takors,R. Impact of Different CO2/HCO3- Levels on Metabolism and Regulation in    Corynebacterium Glutamicum. JOURNAL OF BIOTECHNOLOGY, 168, 331–340.
  12. 2012

    1. Takors,R. Scale-up of Microbial Processes: Impacts, Tools and Open Questions. JOURNAL OF BIOTECHNOLOGY, 160, 3–9.
  13. 2011

    1. Bongaerts,J., Esser,S., Lorbach,V., Al-Momani,L., Mueller,M.A., Franke,D., Grondal,C., Kurutsch,A., Bujnicki,R., Takors,R., et al. Diversity-Oriented Production of Metabolites Derived from Chorismate and    Their Use in Organic Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 7781–7786.
    2. Wenzel,M., Mueller,A., Siemann-Herzberg,M. and Altenbuchner,J. Self-Inducible Bacillus Subtilis Expression System for Reliable and    Inexpensive Protein Production by High-Cell-Density Fermentation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77, 6419–6425.
    3. Vielhauer,O., Zakhartsev,M., Horn,T., Takors,R. and Reuss,M. Simplified Absolute Metabolite Quantification by Gas  Chromatography-Isotope Dilution Mass Spectrometry on the Basis of    Commercially Available Source Material. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL  AND LIFE SCIENCES, 879, 3859–3870.
  14. 2010

    1. Schuhmacher,T., Lemuth,K., Hardiman,T., Vacun,G., Reuss,M. and Siemann-Herzberg,M. Quantifying Cytosolic Messenger RNA Concentrations in Escherichia Coli  Using Real-Time Polymerase Chain Reaction for a Systems Biology Approach. ANALYTICAL BIOCHEMISTRY, 398, 212–217.
    2. Canelas,A.B., Harrison,N., Fazio,A., Zhang,J., Pitkanen,J.-P., van den Brink,J., Bakker,B.M., Bogner,L., Bouwman,J., Castrillo,J.I., et al. Integrated Multilaboratory Systems Biology Reveals Differences in    Protein Metabolism between Two Reference Yeast Strains. NATURE COMMUNICATIONS, 1.
    3. Hardiman,T., Meinhold,H., Hofmann,J., Ewald,J.C., Siemann-Herzberg,M. and Reuss,M. Prediction of Kinetic Parameters from DNA-Binding Site Sequences for    Modeling Global Transcription Dynamics in Escherichia Coli. METABOLIC ENGINEERING, 12, 196–211.
  15. 2009

    1. Magnus,J.B., Oldiges,M. and Takors,R. The Identification of Enzyme Targets for the Optimization of a Valine  Producing Corynebacterium Glutamicum Strain Using a Kinetic Model. BIOTECHNOLOGY PROGRESS, 25, 754–762.
  16. 2008

    1. Lemuth,K., Hardiman,T., Winter,S., Pfeiffer,D., Keller,M.A., Lange,S., Reuss,M., Schmid,R.D. and Siemann-Herzberg,M. Global Transcription and Metabolic Flux Analysis of Escherichia Coli in    Glucose-Limited Fed-Batch Cultivations. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74, 7002–7015.
    2. Hardiman,T., Windeisen,V., Ewald,J.C., Zibek,S., Schlack,P., Rebell,J., Reuss,M. and Siemann-Herzberg,M. In Vitro Synthesis and Characterization of Guanosine 3 `,5  `-Bis(Diphosphate). ANALYTICAL BIOCHEMISTRY, 383, 337–339.
  17. 2007

    1. Noeh,K., Groenke,K., Luo,B., Takors,R., Oldiges,M. and Wiechert,W. Metabolic Flux Analysis at Ultra Short Time Scale: Isotopically  Non-Stationary C-13 Labeling Experiments. JOURNAL OF BIOTECHNOLOGY, 129, 249–267.
    2. Takors,R., Bathe,B., Rieping,M., Hans,S., Kelle,R. and Huthmacher,K. Systems Biology for Industrial Strains and Fermentation Processes -    Example: Amino Acids. JOURNAL OF BIOTECHNOLOGY, 129, 181–190.
    3. van der Werf,M.J., Takors,R., Smedsgaard,J., Nielsen,J., Ferenci,T., Portais,J.C., Wittmann,C., Hooks,M., Tomassini,A., Oldiges,M., et al. Standard Reporting Requirements for Biological Samples in Metabolomics  Experiments: Microbial and in Vitro Biology Experiments. METABOLOMICS, 3, 189–194.
    4. Luo,B., Groenke,K., Takors,R., Wandrey,C. and Oldiges,M. Simultaneous Determination of Multiple Intracellular Metabolites in    Glycolysis, Pentose Phosphate Pathway and Tricarboxylic Acid Cycle by    Liquid Chromatography-Mass Spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1147, 153–164.
    5. Hardiman,T., Lemuth,K., Keller,M.A., Reuss,M. and Siemann-Herzberg,M. Topology of the Global Regulatory Network of Carbon Limitation in    Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 132, 359–374.
  18. 2006

    1. Wahl,S., Takors,R. and Wiechert,W. Interpretation of Metabolic Flux Maps by Limitation Potentials and    Constrained Limitation Sensitivities. BIOTECHNOLOGY AND BIOENGINEERING, 94, 263–272.
    2. Magnus,J.B., Hollwedel,D., Oldiges,M. and Takors,R. Monitoring and Modeling of the Reaction Dynamics in the Valine/Leucine  Synthesis Pathway in Corynebacterium Glutamicum. BIOTECHNOLOGY PROGRESS, 22, 1071–1083.
    3. Franzreb,M., Siemann-Herzberg,M., Hobley,T. and Thomas,O. Protein Purification Using Magnetic Adsorbent Particles. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 70, 505–516.
  19. 2005

    1. Haunschild,M., Freisleben,B., Takors,R. and Wiechert,W. Investigating the Dynamic Behavior of Biochemical Networks Using Model  Families. BIOINFORMATICS, 21, 1617–1625.
    2. Franzreb,M., Ebner,N., Siemann,M., Altenbuchner,J., Fritz,C., Mayer,Z., Schultz,N. and Syldakt,C. Direct Bioproduct Isolation from Crude Feedstocks Using Magnetic Micro  Adsorbents. JOURNAL OF BIOTECHNOLOGY, 118, S53.
    4. Franke,G., Stoepel,N., Reidegeld,K., Siemann-Herzberg,M., Reuss,M., Meyer,H. and Warscheid,B. Quantitative Profiling of the Phosphotransferase System in Escherichia  Coli. MOLECULAR & CELLULAR PROTEOMICS, 4, S319.
    5. Arnold,S., Siemann-Herzberg,M., Schmid,J. and Reuss,M. Model-Based Inference of Gene Expression Dynamics from Sequence  Information. In Nielsen, J (ed), BIOTECHNOLOGY FOR THE FUTURE, BIOTECHNOLOGY FOR THE FUTURE. SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY, Vol. 100, pp. 89–179.
    6. Ternbach,M., Bollman,C., Wandrey,C. and Takors,R. Application of Model Discriminating Experimental Design for Modeling and    Development of a Fermentative Fed-Batch L-Valine Production Process. BIOTECHNOLOGY AND BIOENGINEERING, 91, 356–368.
  20. 2004

    1. Oldiges,M., Kunze,M., Degenring,D., Sprenger,G. and Takors,R. Stimulation, Monitoring, and Analysis of Pathway Dynamics by Metabolic  Profiling in the Aromatic Amino Acid Pathway. BIOTECHNOLOGY PROGRESS, 20, 1623–1633.
    2. Drysch,A., El Massaoudi,M., Wiechert,W., de Graaf,A. and Takors,R. Serial Flux Mapping of Corynebacterium Glutamicum during Fed-Batch  L-Lysine Production Using the Sensor Reactor Approach. BIOTECHNOLOGY AND BIOENGINEERING, 85, 497–505.
    3. Zelic,B., Gostovic,S., Vuorilehto,K., Vasic-Racki,B. and Takors,R. Process Strategies to Enhance Pyruvate Production with Recombinant  Escherichia Coli: From Repetitive Fed-Batch to in Situ Product Recovery  with Fully Integrated Electrodialysis. BIOTECHNOLOGY AND BIOENGINEERING, 85, 638–646.
    4. Takors,R. Complete cell ISPR process development: Chances and risks. CHEMIE INGENIEUR TECHNIK, 76, 1857–1864.
    5. Ruffer,N., Heidersdorf,U., Kretzers,I., Sprenger,G., Raeven,L. and Takors,R. Fully Integrated L-Phenylalanine Separation and Concentration Using  Reactive-Extraction with Liquid-Liquid Centrifuges in a Fed-Batch  Process with E-Coli. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 26, 239–248.
    6. Wahl,A., El Massaoudi,M., Schipper,D., Wiechert,W. and Takors,R. Serial C-13-Based Flux Analysis of an L-Phenylalanine-Producing E-Coli  Strain Using the Sensor Reactor. BIOTECHNOLOGY PROGRESS, 20, 706–714.
    7. Degenring,D., Froemel,C., Dikta,G. and Takors,R. Sensitivity Analysis for the Reduction of Complex Metabolism Models. JOURNAL OF PROCESS CONTROL, 14, 729–745.
    8. Potter,J. and Siemann,M. A New Method for Determining Delta C-13 and Delta D Simultaneously for    CH4 by Gas Chromatography Continuous-Flow Isotope-Ratio Mass  Spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 18, 175–180.
    9. Werner,M., Vazques,F., Fritz,C., Vielhauer,O., Siemann-Herzberg,M., Altenbuchner,J. and Syldatk,C. Cloning of D-Specific Hydantoin Utilization Genes from Arthrobacter  Crystallopoietes. ENGINEERING IN LIFE SCIENCES, 4, 563–572.
    10. Takors,R. Whole Cell ISPR Process Development: Chances and Pitfalls. CHEMIE INGENIEUR TECHNIK, 76, 1807–1814.
    11. Takors,R. Model-Based Analysis and Optimization of an ISPR Approach Using Reactive  Extraction for Pilot-Scale L-Phenylalanine Production. BIOTECHNOLOGY PROGRESS, 20, 57–64.
    12. Zelic,B., Vasic-Racki,D., Wandrey,C. and Takors,R. Modeling of the Pyruvate Production with Escherichia Coli in a Fed-Batch  Bioreactor. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 26, 249–258.
  21. 2003

    1. El Massaoudi,M., Spelthahn,J., Drysch,A., de Graaf,A. and Takors,R. Production Process Monitoring by Serial Mapping of Microbial Carbon Flux  Distributions Using a Novel Sensor Reactor Approach: I - Sensor Reactor  System. METABOLIC ENGINEERING, 5, 86–95.
    2. Franke,D., Lorbach,V., Esser,S., Dose,C., Sprenger,G., Halfar,M., Thommes,J., Muller,R., Takors,R. and Muller,M. (S,S)-2,3-Dihydroxy-2,3-Dihydrobenzoic Acid: Microbial Access with    Engineered Cells of Escherichia Coli and Application as Starting  Material in Natural-Product Synthesis. CHEMISTRY-A EUROPEAN JOURNAL, 9, 4188–4196.
    3. Drysch,A., El Massaoudi,M., Mack,C., Takors,R., de Graaf,A. and Sahm,H. Production Process Monitoring by Serial Mapping of Microbial Carbon Flux  Distributions Using a Novel Sensor Reactor Approach: II -    C-13-Labeling-Based Metabolic Flux Analysis and L-Lysine Production. METABOLIC ENGINEERING, 5, 96–107.
    4. Zelic,B., Gerharz,T., Bott,M., Vasic-Racki,D., Wandrey,C. and Takors,R. Fed-Batch Process for Pyruvate Production by Recombinant Escherichia  Coli YYC202 Strain. ENGINEERING IN LIFE SCIENCES, 3, 299–305.
    5. Oelschlaeger,P., Lange,S., Schmitt,J., Siemann,M., Reuss,M. and Schmid,R. Identification of Factors Impeding the Production of a Single-Chain  Antibody Fragment in Escherichia Coli by Comparing in Vivo and in Vitro  Expression. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 61, 123–132.
  22. 2002

    1. Gerigk,M., Maass,D., Kreutzer,A., Sprenger,G., Bongaerts,J., Wubbolts,M. and Takors,R. Enhanced Pilot-Scale Fed-Batch L-Phenylalanine Production with    Recombinant Escherichia Coli by Fully Integrated Reactive Extraction. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 25, 43–52.
    2. Maass,D., Gerigk,M., Kreutzer,A., Weuster-Botz,D., Wubbolts,M. and Takors,R. Integrated L-Phenylalanine Separation in an E-Coli Fed-Batch Process:    from Laboratory to Pilot Scale. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 25, 85–96.
    3. Schmitz,M., Hirsch,E., Bongaerts,J. and Takors,R. Pulse Experiments as a Prerequisite for the Quantification of in Vivo  Enzyme Kinetics in Aromatic Amino Acid Pathway of Escherichia Coli. BIOTECHNOLOGY PROGRESS, 18, 935–941.
    4. Abendroth,J., Niefind,K., May,O., Siemann,M., Syldatk,C. and Schomburg,D. The Structure of L-Hydantoinase from Arthobacter Aurescens Leads to an    Understanding of Dihydropyrimidinase Substrate and Enantio Specificity. BIOCHEMISTRY, 41, 8589–8597.
    5. Gerigk,M., Bujnicki,R., Ganpo-Nkwenkwa,E., Bongaerts,J., Sprenger,G. and Takors,R. Process Control for Enhanced L-Phenylalanine Production Using Different  Recombinant Escherichia Coli Strains. BIOTECHNOLOGY AND BIOENGINEERING, 80, 746–754.
  23. 2001

    1. Altenbuchner,J., Siemann-Herzberg,M. and Syldatk,C. Hydantoinases and Related Enzymes as Biocatalysts for the Synthesis of    Unnatural Chiral Amino Acids. CURRENT OPINION IN BIOTECHNOLOGY, 12, 559–563.
    2. Wilms,B., Hauck,A., Reuss,M., Syldatk,C., Mattes,R., Siemann,M. and Altenbuchner,J. High-Cell-Density Fermentation for Production of L-N-Carbamoylase Using  an Expression System Based on the Escherichia Coli RhaBAD Promoter. BIOTECHNOLOGY AND BIOENGINEERING, 73, 95–103.
    3. Curvers,S., Linneman,J., Klauser,T., Wandrey,C. and Takors,R. Recombinant Protein Production with Pichia Pastoris in Continuous  Fermentation - Kinetic Analysis of Growth and Product Formation. CHEMIE INGENIEUR TECHNIK, 73, 1615–1621.
    4. Buchholz,A., Takors,R. and Wandrey,C. Quantification of Intracellular Metabolites in Escherichia Coli K12  Using Liquid Chromatographic-Electrospray Ionization Tandem Mass  Spectrometric Techniques. ANALYTICAL BIOCHEMISTRY, 295, 129–137.
    5. Takors,R., Gerigk,M., Paschold,H. and Wandrey,C. Principal-Component Analysis for Microbial L-Phenylalanine Production. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 24, 93–99.
    6. Arnold,S., Siemann,M., Scharnweber,K., Werner,M., Baumann,S. and Reuss,M. Kinetic Modeling and Simulation of in Vitro Transcription by Phage T7  RNA Polymerase. BIOTECHNOLOGY AND BIOENGINEERING, 72, 548–561.
  24. 2000

    1. Schmitz,G., Franke,D., Stevens,S., Takors,R., Weuster-Botz,D. and Wandrey,C. Regioselective Oxidation of Terfenadine with Cunninghamella Blakesleeana. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 10, 313–324.
    2. Schindler,P., Baumann,S., Reuss,M. and Siemann,M. In Vitro Coupled Transcription Translation: Effects of Modification in    Lysate Preparation on Protein Composition and Biosynthesis Activity. ELECTROPHORESIS, 21, 2606–2609.
  25. 1999

    1. Syldatk,C., May,O., Altenbuchner,J., Mattes,R. and Siemann,M. Microbial Hydantoinases - Industrial Enzymes from the Origin of Life? APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 51, 293–309.
    2. Schaefer,U., Boos,W., Takors,R. and Weuster-Botz,D. Automated Sampling Device for Monitoring Intracellular Metabolite  Dynamics. ANALYTICAL BIOCHEMISTRY, 270, 88–96.
    3. Siemann,M., Alvarado-Marin,A., Pietzsch,M. and Syldatk,C. A D-Specific Hydantoin Amidohydrolase: Properties of the Metalloenzyme  Purified from Arthrobacter Crystallopoietes. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 6, 387–397.
    4. Schindler,P., Macherhammer,F., Arnold,S., Reuss,M. and Siemann,M. Investigation of Translation Dynamics under Cell-Free Protein  Biosynthesis Conditions Using High-Resolution Two-Dimensional Gel  Electrophoresis. ELECTROPHORESIS, 20, 806–812.
  26. 1998

    1. May,O., Siemann,M., Siemann,M. and Syldatk,C. Catalytic and Structural Function of Zinc for the Hydantoinase from    Arthrobacter Aurescens DSM 3745. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 4, 211–218.
    2. May,O., Siemann,M., Pietzsch,M., Kiess,M., Mattes,R. and Syldatk,C. Substrate-Dependent Enantioselectivity of a Novel Hydantoinase from    Arthrobacter Aurescens DSM 3745: Purification and Characterization as    New Member of Cyclic Amidases. JOURNAL OF BIOTECHNOLOGY, 61, 1–13.
    3. May,O., Siemann,M., Siemann,M. and Syldatk,C. The Hydantoin Amidohydrolase from Arthrobacter Aurescens DSM 3745 Is a    Zinc Metalloenzyme. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 5, 367–370.
    4. May,O., Habenicht,A., Mattes,R., Syldatk,C. and Siemann,M. Molecular Evolution of Hydantoinases. BIOLOGICAL CHEMISTRY, 379, 743–747.
    5. May,O., Siemann,M. and Syldatk,C. A New Method for the Detection of Hydantoinases with Respect to Their  Enantioselectivity on Acrylamide Gels Based on Enzyme Activity Stain. BIOTECHNOLOGY TECHNIQUES, 12, 309–312.
  27. 1997

    1. Siemann,M., Andersson,L. and Mosbach,K. Separation and Detection of Macrolide Antibiotics by HPLC Using  Macrolide-Imprinted Synthetic Polymers as Stationary Phases. JOURNAL OF ANTIBIOTICS, 50, 89–91.
    2. Takors,R., Wiechert,W. and WeusterBotz,D. Experimental Design for the Identification of Macrokinetic Models and    Model Discrimination. BIOTECHNOLOGY AND BIOENGINEERING, 56, 564–576.
  28. 1996

    1. May,O., Siemann,M., Syldatk,C., Niefind,K. and Schomburg,D. Crystallization and Preliminary X-Ray Analysis of a Hydantoinase from    Arthrobacter Aurescens DSM 3745. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 52, 1209–1210.
    2. Katanaev,V., Spirin,A., Reuss,M. and Siemann,M. Formation of Bacteriophage MS2 Infectious Units in a Cell-Free  Translation System. FEBS LETTERS, 397, 143–148.
    3. Siemann,M., Andersson,L. and Mosbach,K. Selective Recognition of the Herbicide Atrazine by Noncovalent  Molecularly Imprinted Polymers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 44, 141–145.
  29. 1994

  30. 1993

  31. 2018

    1. Barbosa,S., Niebel,B., Wolf,S., Mauch,K. and Takors,R. (2018) A Guide to Gene Regulatory Network Interference for Obtaining Predictive Solutions: Underlying Assumptions and Fundamental Biological and Data Constraints. BioSystems, 174, 37–48.
    2. Schwentner,A., Feith,A., Münch,E., Busche,T., Rückert,C., Kalinowskis,J., Takors,R. and Blombach,B. (2018) Metabolic Engineering to Guide Evolution - Creating a Novel Mode for L-Valine Production with Corynebacterium Glutamicum. Metabolic Engineering, 47, 31–41.
  32. 2017

    1. Wolf,S., Barbosa,S., Bücher,J. and Takors,R. (2017) Automatic Network Generation Describes Differential Gene Data in User Friendly and Expeditiously Analyzable Network Views. 2, 1–14.
    2. Pfreundt,U., Spungin,D., Hou,S., Voß,B., Berman-Frank,I. and Hess,W.R. (2017) Genome of a Giant Bacteriophage from a Decaying Trichodesmium Bloom. Marine Genomics, 33, 21–25.
    3. Kuschel,M., Siebler,F. and Takors,R. (2017) Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors. Bioengineering, 4, 27.
    4. Hellmers,F., Takors,R. and Thum,O. (2017) Robust Enzyme Immobilizates for Industrial Isomalt Production. Molecular Catalysis, 445, 293–298.
  33. 2016

    1. Sudarsan,S., Blank,L.M., Dietrich,A., Vielhauer,O., Takors,R., Schmid,A. and Reuss,M. (2016) Dynamics of Benzoate Metabolism in Pseudomonas Putida KT2440. Metabolic Engineering Communications, 3, 97–110.
    2. Stazic,D. and Voß,B. (2016) The Complexity of Bacterial Transcriptomes. Journal of Biotechnology, 232, 69--78.
    3. Álvarez,D., Voß,B., Maass,D., Wüst,F., Schaub,P., Beyer,P. and Welsch,R. (2016) 5’UTR-Mediated Translational Control of Splice Variants of Phytoene Synthase. Plant Physiol.
    4. Schäfer,R.A. and Voß,B. (2016) VisualGraphX: Interactive Graph Visualization within Galaxy. Bioinformatics, 10.1093/bioinformatics/btw414.
  34. 2015

    1. Kopf,M., Klähn,S., Scholz,I., Hess,W.R. and Voß,B. (2015) Variations in the Non-Coding Transcriptome as a Driver of Inter-Strain Divergence and Physiological Adaptation in Bacteria. Scientific Reports, 5.
    2. Blombach,B. and Takors,R. (2015) CO2 - Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes. Front Bioeng Biotechnol, 3, 108.
    3. Lott,S.C., Voß,B., Hess,W.R. and Steglich,C. (2015) CoVennTree: A New Method for the Comparative Analysis of Large Datasets. Bioinformatics and Computational Biology, 6, 43.
  35. 2014

    1. Kopf,M., Klähn,S., Pade,N., Weingärtner,C., Hagemann,M., Voß,B. and Hess,W.R. (2014) Comparative Genome Analysis of the Closely Related Synechocystis Strains PCC 6714 and PCC 6803. DNA Research, 21, 255--266.
    2. Kopf,M., Klähn,S., Voß,B., Stüber,K., Huettel,B., Reinhardt,R. and Hess,W.R. (2014) Finished Genome Sequence of the Unicellular Cyanobacterium Synechocystis Sp. Strain PCC 6714. Genome Announcements, 2, e00757--14.
    3. Voß,B. and Hess,W.R. (2014) The Identification of Bacterial Non-Coding RNAs through Complementary Approaches. In Handbook of RNA Biochemistry, Handbook of RNA Biochemistry. WILEY-VCH, Weinheim, Germany, Vol. 2, pp. 787--800.
    4. Bischler,T., Kopf,M. and Voß,B. (2014) Transcript Mapping Based on DRNA-Seq Data. BMC Bioinformatics, 15, 122.
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