Zeitschriftenbeiträge
2023
- Ulmer,A.U., Veit,S., Erdemann,F., Freund,A., Loesch,M., Teleki,A., Zeidan,A.A. and Takors,R. (2023) A Two‐Compartment Fermentation System to Quantify Strain‐Specific Interactions in Microbial Co‐Cultures. Bioengineering, 10.
- Wild,M., Mast,Y. and Takors,R. (2023) Revisiting Basics of KLa Dependency on Aeration in Bubble Columns: A Is Surprisingly Stable. Chemie Ingenieur Technik, 95, 1–8.
- Cordell,W.T., Avolio,G., Takors,R. and Pfleger,B.F. (2023) Milligrams to Kilograms: Making Microbes work at Scale. TIBTEC, doi.org/10.1016/j.tibtech.2023.05.00.
- Matamouros,S., Gensch,T., Cerff,M., Sachs,C.C., Abdollahzadeh,I., Hendrick,J., Horst,L., Tenhaef,N., Tenhaef,J., Noack,S., et al. (2023) Growth-Rate Dependency of Ribosome Abundance and Translation Elongation Rate in Corynebacterium Glutamicum Differs from That in Escherichia Coli. Nature Communications, 14.
- Minden,S., Aniolek,M., Noorman,H. and Takors,R. (2023) Mimicked Mixing-Induced Heterogeneities of Industrial Stimulate Long-Lasting Adaption Programs in Ethanol-Producing Yeasts. genes, 14.
- Mast,Y. and Takors,R. (2023) Transferring Bubble Breakage Models Tailored for Euler-Euler to Euler-Lagrange Simulations. processes, 11, 1–22.
- Lataster,L., Huber,H.M., Böttcher,C., Föller,S., Takors,R. and Radziwill,G. (2023) Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein P21. Biology, 12.
- Bendig,T., Ulmer,A., Luzia,L., Müller,S., Sahle,S., Bergmann,F.T., Lösch,M., Erdemann,F., Zeidan,A.A., Mendoza,S.N., et al. (2023) The PH-Dependent Lactose Metabolism of Lactobacillus Delbrueckii Subsp. Bulgaricus: An Integrative View through a Mechanistic Computational Model. J Biotechnol.
- Pfleger,B.F. and Takors,R. (2023) Recent Progress in the Synthesis of Advanced Biofuel and Bioproducts. Current Opinion in Biotechnology, 80, 1–10.
2022
- Minden,S., Aniolek,M., Hajian,C.S.S., Teleki,A., Zerrer,T., Delvigne,F., van Gulik,W., Deshmukh,A., Noorman,H. and Takors,R. (2022) Monitoring Intracellular Metabolite Dynamics in Saccharomyces Cerevisiae during Industrially Relevant Famine Stimuli. metabolites, 12.
- Hildenbrand,J.C., Sprenger,G.A., Teleki,A., Takors,R. and Jendrossek,D. (2022) Polyphosphate Kinases Phosphorylate Thiamine Phosphates. Microbial Physiology, https://doi.org/10.1159/000526662.
- Rehnert,M. and Takors,R. (2022) FAIR Research Data Management as Community Approach in Bioengineering. Engineering in Life Science, DOI: 10.1002/elsc.202200005.
- Müller,T., Schick,S., Beck,J., Sprenger,G. and Takors,R. (2022) Synthetic Mutualism in Engineered E. Coli Mutant Strains as Functional Basis for Microbial Production Consortia. Engineering in Life Science, doi.org/10.1002/elsc.20210015.
- Gaugler,L., Mast,Y., Fitschen,J., Hofmann,S., Schlüter,M. and Takors,R. (2022) Scaling-down Biopharmaceutical Production Processes via a Single Multi-Compartment Bioreactor (SMCB). Engineering in life sciences, DOI: 10.1002/elsc.202100161.
- Ulmer,A., Erdemann,F., Mueller,S., Loesch,M., Wildt,S., Jensen,M.L., Gaspar,P., Zeidan,A.A. and Takors,R. (2022) Differential Amino Acid Uptake and Depletion In-Cultures and Co-Cultures of Streptococcus Thermophilus and Lactobacillus Delbrueckii Subsp. Bulgaricus in a Novel Semi-Synthetic Medium. microorganisms, 10.
- Minden,S., Aniolek,M., Noorman,H. and Takors,R. (2022) Performing in Spite of Starvation: How Saccharomyces Cerevisiae Maintains Robust Growth When Facing Famine Zones in Industrial Bioreactors. Microbial Biotechnology, 16, 148--168.
- Schmidt,C., Trinkmann,F., Takors,R., Cattaneo,G. and Port,J. (2022) Investigation of Tracer Gas Transport in a New Numerical Model of Lung Acini. Medical & Biological Engineering & Computing.
2021
- Wijaya,A.W., Ulmer,A., Hundsdorfer,L., Verhagen,N., Teleki,A. and Takors,R. (2021) Compartment‑specific Metabolome Labeling Enables the Identification of Subcellular Fluxes That May Serve as Promising Metabolic Engineering Targets in CHO Cells. Bioprocess and Biosystems Engineering, 10.1007/s00449-021-02628-1.
- Perpelea,A., Wijaya,A.W., Martins,L.C., Rippert,D., Klein,M., Angelov,A., Peltonen,K., Teleki,A., Liebl,W., Richard,P., et al. (2021) Towards Valorization of Pectin-Rich Agro-Industrial Residues: Engineering of Saccharomyces Cerevisiae for Co-Fermentation of d-Galacturonic Acid and Glycerol. Metabolic Engineering, 10.1016/j.ymben.2021.10.001.
- Ziegler,M., Zieringer,J., Döring,C.-L., Paul,L., Schaal,C. and Takors,R. (2021) Engineering a Robust Escherichia Coli Chassis and Exploitation for Large-Scale Production Process. Metabolic Engineering, 67, 75–87.
- Kappelmann,J., Klein,B., Papenfuß,M., Lange,J., Blombach,B., Takors,R., Wiechert,W., Polen,T. and Noack,S. (2021) Comprehensive Analysis of C. Glutamicum Anaplerotic Deletion Mutants Under Defined D-Glucose Conditions. Frontiers in Bioengineering and Biotechnology, 8.
- Hermann,M., Teleki,A., Weitz,S., Niess,A., Freund,A., Bengelsdorf,F.R., Dürre,P. and Takors,R. (2021) Identifying and Engineering Bottlenecks of Autotrophic Isobutanol Formation in Recombinant C. Ljungdahlii by Systemic Analysis. Frontiers in Bioengineering and Biotechnology, 9.
- Weitz,S., Hermann,M., Linder,S., Bengelsdorf,F.R., Takors,R. and Dürre,P. (2021) Isobutanol Production by Autotrophic Acetogenic Bacteria. Frontiers in Bioengineering and Biotechnology, 10.3389/fbio.2021.657253.
- Demling,P., Ankenbauer,A., Klein,B., Noack,S., Tiso,T., Takors,R. and Blank,L.M. (2021) Pseudomonas Putida KT2440 Endures Temporary Oxygen Limitations. Biotechnology and Bioengineering, 10.1002/bit.27938.
- Ziegler,M., Hägele,L., Gäbele,T. and Takors,R. (2021) CRISPRi Enables Fast Growth Followed by Stable Aerobic Formation in Escherichia Coli without Auxotrophy. Engineering in Life Science, 10.1002/elsc.202100021.
- Wijaya,A.W. and Takors,R. (2021) A Transhydrogenase-like Mechanism in CHO Cells Comprising Concerted Reaction and Mitochondrial Shuttling Activities. Biochemical Engineering Journal, 170.
- Schäfer,R.A. and Voß,B. (2021) RNAnue: Efficient Data Analysis for RNA–RNA Interactomics. Nucleic Acids Research, 10.1093/nar/gkab340.
- Huang,J. and Voß,B. (2021) Simulation of Folding Kinetics for Aligned RNAs. Genes, 12, 347.
- Ankenbauer,A., Nithschel,R., Müller,T., Favelli,L., Blombach,B. and Takors,R. (2021) Micro-Aerobic Production of Isobutanol with Engineered Pseudomonas Putida. Engineering in Life Science.
- Märkle,P., Maier,L.-K., Maaß,S., Hirschfeld,C., Bartel,J., Becher,D., Voß,B. and Marchfelder,A. (2021) A Small RNA Is Linking CRISPR-Cas and Zinc Transport. Frontiers in Molecular Biosciences, 8.
- Wijaya,A.W., Verhagen,N., Teleki,A. and Takors,A. (2021) Compartment-Specific 13C Metabolic Flux Analysis Reveals Boosted NADPH Availability Coinciding with Increased Cell-Specific Productivity for IgG1 Producing CHO Cells after MTA Treatment. Engineering in Life Science, 10.1002/elsc.202100057.
2020
- Verhagen,N., Wijaya,A.W., Teleki,A., Fadhlullah,M., Unsöld,A., Schilling,M., Heinrich,C. and Takors,R. (2020) Comparison of L-Tyrosine Containing Dipeptides Reveals ATP Availability for l-Prolyl-l-Tyrosine in CHO. Engineering in Life Science, 10.1002/elsc.202000017.
- Ziegler,M., Zieringer,J. and Takors,R. (2020) Transcriptional Profiling of the Stringent Response Mutant Strain E. Coli SR Reveals Enhanced Robustness to Large-Scale Conditions. microbial biotechnology, 10.1111/1751-7915.13738.
- Zieringer,J., Wild,M. and Takors,R. (2020) Data‐driven in Silico Prediction of Regulation heterogeneity and ATP Demands of Escherichia Coli in Large‐scale Bioreactors. Biotechnol. Bioeng., 118, 265–278.
- Verhagen,N., Zieringer,J. and Takors,R. (2020) Methylthioadenosine (MTA) Boosts Cell-Specific Productivities of Chinese Hamster Ovary Cultures: Dosage Effects on Proliferation, Cell Cycle and Gene Expression. FEBS Open Bio, 10, 2791–2804.
- Feith,A., Schwentner,A., Teleki,A., Favilli,L., Blombach,B. and Takors,R. (2020) Streamlining the Analysis of Dynamic 13C-Labeling for the Metabolic Engineering of Corynebacterium Glutamicum as l-Histidine Production Host. Metabolites, 10.
- Müller,F., Rapp,J., Hacker,A.-L., Feith,A., Takors,R. and Blombach,B. (2020) CO2/HCO3- Accelerates Iron Reduction through Phenolic Compounds. mbio.
- Hermann,M., Teleki,A., Weitz,S., Niess,A., Freund,A., Bengelsdorf,F.R. and Takors,R. (2020) Electron Availability in CO2, CO and H2 Mixtures Flux Distribution, Energy Management and product Formation in Clostridium Ljungdahlii. Microbial Biotechnology, 10.1111/1751-7915.13625.
- Verhagen,N., Teleki,A., Heinrich,C., Schilling,M., Unsoeld,A. and Takors,R. (2020) S-Adenosylmethionine and Methylthioadenosine Boost Cellular Productivities of Antibody Forming Chinese Hamster Ovary Cells. Biotechnol. Bioeng., 10.1002/bit.27484.
- Schäfer,R.A., Lott,S.C., Georg,J., Grüning,B.A., Hess,W.R. and Voß,B. (2020) GLASSGo in Galaxy: High-Throughput, Reproducible and Easy-to-Integrate Prediction of SRNA Homologs. Bioinformatics, 10.1093/bioinformatics/btaa556.
- Müller,J., Siemann-Herzberg,M. and Takors,R. (2020) Modeling Cell-Free Protein Synthesis—Approaches And. Frontiers in Bioengineering and Biotechnology, https://doi.org/10.3389/fbioe.2020.584178.
- Patil,V., Santos,C.N.S., Ajikumar,P.K., Sarria,S. and Takors,R. (2020) Balancing Glucose and Oxygen Uptake Rates to Enable High Amorpha‐4,11‐diene Production in Escherichia Coli via the Methylerythritol Phosphate Pathway. Biotechnol. Bioeng., 10.1002/bit.27655.
- Sarkizi Shams Hajian,C., Haringa,C., Noorman,H. and Takors,R. (2020) Predicting By-Product Gradients of Baker’s Yeast at Industrial Scale: A Practical Simulation Approach. Processes, 8.
- Graf,M., Haas,T., Teleki,A., Feith,A., Cerff,M., Wiechert,W., Noeh,K., Busche,T., Kalinowski,J. and Takors,R. (2020) Revisiting the Growth Modulon of Corynebacterium Glutamicum Under Glucose Limited Chemostat. Frontiers in Bioengineering and Biotechnology, 10.3389/fbioe.2020.584614.
- Kuschel,M. and Takors,R. (2020) Simulated Oxygen and Glucose Gradients as a Prerequisite for predicting Industrial Scale Performance a Priori. Biotechnol. Bioeng., 117, 2760–2770.
- Ankenbauer,A., Schäfer,R.A., Viegas,S.C., Pobre,V., Voß,B., Arraiano,C.M. and Takors,R. (2020) Pseudomonas Putida KT2440 Is Naturally Endowed to Withstand Industrial-Scale Stress Conditions. Microbial Biotechnology, n/a.
- Siebler,F., Lapin,A. and Takors,R. (2020) Synergistically Applying 1D Modeling and CFD for Designing Industrial Scale Bubble Column Syngas Bioreactors. Engineering in Life Science, 10.1002/elsc.201900132.
- Alkhnbashi,O.S., Meier,T., Mitrofanov,A., Backofen,R. and Voß,B. (2020) CRISPR-Cas Bioinformatics. Methods, 172, 3–11.
2019
- Graf,M., Haas,T., Müller,F., Buchmann,A., Harm-Betbenbetova,J., Freund,A., Nieß,A., Persicke,M., Kalinowski,J., Blombach,B., et al. (2019) Continuous Adaptive Evolution of a Fast-Growing Corynebacterium Glutamicum Strain Independent of Protocatechuate. Frontiers in Microbiology, 10.3389/fmicb.2019.01648.
- Straathof,A.J.J., Wahl,S.A., Benjamin,K.R., Takors,R., Wierckx,N. and Noorman,H.J. (2019) Grand Research Challenges for Sustainable Industrial Biotechnology. Trends in Biotechnology, https://doi.org/10.1016/j.tibtech.2019.04.002.
- Nieß,A., Siemann-Herzberg,M. and Takors,R. (2019) Protein Production in Escherichia Coli Guided by the Trade‑off between Intracellular Availability and Energy Cost. Microbial Cell Factories, 18.
- Grenz,S., Baumann,P.T., Rückert,C., Nebel,B.A., Siebert,D., Schwentner,A., Eikmanns,B.J., Hauer,B., Kalinowsk, i J., Takors,R., et al. (2019) Exploting Hydrogenophage Pseudoflava for Aerobic Syngas-Based Production of Chemicals. Metabolic Engineering, 55, 220–230.
- Nitschel,R., Ankenbauer,A., Welsch,I., Wirth,N.T., Massner,C., Ahmad,N., McColm,S., Borges,F., Fotheringham,I., Takors,R., et al. (2019) Engineering Pseudomonas Putida KT2440 for the production of Isobutanol. Engineering in Life Science, 20, 148–159.
- Niess,A., Siemann-Herzberg,M. and Takors,R. (2019) Protein Production in Escherichia Coli Is Guided by the Trade-off between Intracellular Substrate Availability and Energy Cost. Microbial Cell Factory, 18.
- Junghans,L., Teleki,A., Wijaya,A., Becker,M., Schweikert,M. and Takors,R. (2019) From Nutrional Wealth to Autophagy: In Vivo Metabolic Dynamics in the Cytosol, Mitochondrion and Shuttles of IgG Producing CHO Cells. Metabolic Engineering, 54, 145–159.
- Becker,M., Junghans,L., Teleki,A., Bechmann,J. and Takors,R. (2019) The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies with Chinese Hamster Ovary Cells. Frontiers in Bioengineering and Biotechnlogy, 7.
- Haas,T., Graf,M., Nieß,A., Busche,T., Kalinowski,J., Blombach,B. and Takors,T. (2019) Identifying the Growth Modulon of Corynebacterium Glutamicum. Frontiers in Microbiology, 10.
- Schwentner,A., Feith,A., Münch,E., Stiefelmaier,J., Lauer,I., Favilli,L., Massner,C., Öhrlein,J., Grund,B., Hüser,A., et al. (2019) Modular Systems Metabolic Engineering Enables Balancing of Relevant Pathways for L-Histidine Production with Corynebacterium Glutamicum. Biotechnology for Biofuels, 12.
- Becker,M., Junghans,L., Teleki,A., Bechmann,J. and Takors,R. (2019) Perfusion Cultures Equire Optimum Respiratory ATP Supply to Maximize Cell‐specific and Volumetric Productivities. Biotechnol. Bioeng., 10.1002/bit.26926.
- Pobre,V., Graça-Lopes,G., Saramago,M., Ankenbauer,A., Takors,T., Arraiano,C.M. and Viegas,S.C. (2019) Prediction of Novel Non-Coding RNAs Relevant for the Growth of Pseudomonas Putida in a Bioreactor. Microbiology.
- Takors,R. (2019) Biochemical Engineering Provides Mindset, Tools and solutions for the Driving Questions of a Sustainable Future. Engineering in Life Science, 10.1002/elsc.201900150.
- Ziegler,M. and Takors,R. (2019) Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis. In: Minimal Cells: Design, Construction, Biotechnological Applications. In Lara,A.R., Gosset Lagarda,G. (eds).
- Siebler,F., Lapin,A., Hermann,M. and Takors,R. (2019) The Impact of CO Gradients on C. Ljungdahlii in a 125 M3 Bubble Column: Mass Transfer, Circulation Time and Lifeline Analysis. Chemical Engineering Science, 207, 410–423.
- Feith,A., Teleki,A., Graf,M., Favilli,L. and Takors,R. (2019) HILIC-Enabled 13C Metabolomics Strategies: Comparing Quantitative Precision and Spectral Accuracy of QToF High - and QQQ Low-Resolution Mass Spectrometry. Metabolites, 10.3390/metabo9040063.
2018
- Lange,J., Mueller,F., Takors,R. and Blombach,B. Harnessing Novel Chromosomal Integration Loci to Utilize an Organosolv-Derived Hemicellulose Fraction Forisobutanol Production with Engineered Corynebacterium Glutamicum. MICROBIAL BIOTECHNOLOGY, 11, 257–263.
- Takors,R., Kopf,M., Mampel,J., Bluemke,W., Blombach,B., Eikmanns,B., Bengelsdorf,F.R., Weuster‐Botz,D. and Dürre,P. (2018) Using Gas Mixtures of CO, CO2 and H2 as Microbial Substrates: The Do’s and Don’ts of Successful Technology Transfer from Laboratory to Production Scale. Microbial Biotechnology, 11.
- Failmezger,J., Scholz,S., Blombach,B. and Siemann-Herzberg,M. (2018) Cell-Free Protein Synthesis From Fast-Growing Vibrio Natriegens. Frontiers in Microbiology, 9.
- Schönberger,B., Schaal,C., Schäfer,R. and Voß,B. (2018) RNA Interactomics: Recent Advances and Remaining Challenges. F1000Research, 7, 1824.
- Lott,S.C., Schäfer,R.A., Mann,M., Backofen,R., Hess,W.R., Voß,B. and Georg,J. (2018) GLASSgo - Automated and Reliable Detection of SRNA Homologs from a Single Input Sequence. Frontiers in Genetics, 9.
- Zieringer,J. and Takors,R. (2018) In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models. Computational and Structural Biotechnology Journal, 16, 246–256.
- Graf,M., Zieringer,J., Haas,T., Nieß,A., Blombach,B. and Takors,R. (2018) Physiological Response of Corynebacterium Glutamicum to Increasingly Nutrient-Rich Growth Conditions. Frontiers in Microbiology, 9.
- Lange,J., Münch,E., Müller,J., Busche,T., Kalinowski,J., Takors,R. and Blombach,B. (2018) Deciphering the Adaptation of Corynebacterium Glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis. Genes, 9, 297.
2017
- Niess,A., Failmezger,J., Kuschel,M., Siemann-Herzberg,M. and Takors,R. Experimentally Validated Model Enables Debottlenecking of in Vitro Protein Synthesis and Identifies a Control Shift under in Vivo Conditions. ACS SYNTHETIC BIOLOGY, 6, 1913–1921.
- Michalowski,A., Siemann-Herzberg,M. and Takors,R. Escherichia Coli HGT: Engineered for High Glucose Throughput Even under Slowly Growing or Resting Conditions. METABOLIC ENGINEERING, 40, 93–103.
- Niess,A., Loeffler,M., Simen,J.D. and Takors,R. Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E-Coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model. FRONTIERS IN MICROBIOLOGY, 8.
- Simen,J.D., Loeffler,M., Jaeger,G., Schaeferhoff,K., Freund,A., Matthes,J., Mueller,J., Takors,R. and RecogNice-Team Transcriptional Response of Escherichia Coli to Ammonia and Glucose Fluctuations. MICROBIAL BIOTECHNOLOGY, 10, 858–872.
- Delvigne,F., Takors,R., Mudde,R., van Gulik,W. and Noorman,H. Bioprocess Scale-up/down as Integrative Enabling Technology: From Fluid Mechanics to Systems Biology and Beyond. MICROBIAL BIOTECHNOLOGY, 10, 1267–1274.
- Teleki,A., Rahnert,M., Bungart,O., Gann,B., Ochrombel,I. and Takors,R. Robust Identification of Metabolic Control for Microbial L-Methionine Production Following an Easy-to-Use Puristic Approach. METABOLIC ENGINEERING, 41, 159–172.
- Lange,J., Mueller,F., Bernecker,K., Dahmen,N., Takors,R. and Blombach,B. Valorization of Pyrolysis Water: A Biorefinery Side Stream, for 1,2-Propanediol Production with Engineered Corynebacterium Glutamicum. BIOTECHNOLOGY FOR BIOFUELS, 10.
- Failmezger,J., Rauter,M., Nitschel,R., Kraml,M. and Siemann-Herzberg,M. Cell-Free Protein Synthesis from Non-Growing, Stressed Escherichia Coli. SCIENTIFIC REPORTS, 7.
- Hoffart,E., Grenz,S., Lange,J., Nitschel,R., Mueller,F., Schwentner,A., Feith,A., Lenfers-Luecker,M., Takors,R. and Blombach,B. High Substrate Uptake Rates Empower Vibrio Natriegens as Production Host for Industrial Biotechnology. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83.
- Loeffler,M., Simen,J.D., Mueller,J., Jaeger,G., Laghrami,S., Schaeferhoff,K., Freund,A., Takors,R. and RecogNice-Team Switching between Nitrogen and Glucose Limitation: Unraveling Transcriptional Dynamics in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 258, 2–12.
- Eigenstetter,G. and Takors,R. Dynamic Modeling Reveals a Three-Step Response of Saccharomyces Cerevisiae to High CO2 Levels Accompanied by Increasing ATP Demands. FEMS YEAST RESEARCH, 17.
- Failmezger,J., Ludwig,J., Niess,A. and Siemann-Herzberg,M. Quantifying Ribosome Dynamics in Escherichia Coli Using Fluorescence. FEMS MICROBIOLOGY LETTERS, 364.
- Lange,J., Takors,R. and Blombach,B. Zero-Growth Bioprocesses: A Challenge for Microbial Production Strains and Bioprocess Engineering. ENGINEERING IN LIFE SCIENCES, 17, 27–35.
2016
- Takors,R. and de Lorenzo,V. Editorial Overview: Microbial Systems Biology: Systems Biology Prepares the Ground for Successful Synthetic Biology. CURRENT OPINION IN MICROBIOLOGY, 33, VIII–X.
- Loeffler,M., Simen,J.D., Jaeger,G., Schaeferhoff,K., Freund,A. and Takors,R. Engineering E-Coli for Large-Scale Production - Strategies Considering ATP Expenses and Transcriptional Responses. METABOLIC ENGINEERING, 38, 73–85.
- Failmezger,J., Nitschel,R., Sanchez-Kopper,A., Kraml,M. and Siemann-Herzberg,M. Site-Specific Cleavage of Ribosomal RNA in Escherichia Coli-Based Cell-Free Protein Synthesis Systems. PLoS One, 11.
- Junghans,L., Teleki,A., Becker,M. and Takors,R. LC-MS-Based Compartment-Specific Metabolome Analysis in CHO. NEW BIOTECHNOLOGY, 33, S33–S34.
- Wutz,J., Lapin,A., Siebler,F., Schaefer,J.E., Wucherpfennig,T., Berger,M. and Takors,R. Predictability of k(L)a in Stirred Tank Reactors under Multiple Operating Conditions Using an Euler-Lagrange Approach. ENGINEERING IN LIFE SCIENCES, 16, 633–642.
- Pfizenmaier,J., Junghans,L., Teleki,A. and Takors,R. Hyperosmotic Stimulus Study Discloses Benefits in ATP Supply and Reveals MiRNA/MRNA Targets to Improve Recombinant Protein Production of CHO Cells. BIOTECHNOLOGY JOURNAL, 11, 1037–1047.
- Takors,R. Editorial: How Can We Ensure the Successful Transfer from Lab- to Large-Scale Production? ENGINEERING IN LIFE SCIENCES, 16, 587.
- Sanchez-Kopper,A., Becker,M., Pfizenmaier,J., Kessler,C., Karau,A. and Takors,R. Tracking Dipeptides at Work-Uptake and Intracellular Fate in CHO Culture. AMB EXPRESS, 6.
- Lieder,S., Jahn,M., Koepff,J., Mueller,S. and Takors,R. Environmental Stress Speeds up DNA Replication in Pseudomonas Putida in Chemostat Cultivations. BIOTECHNOLOGY JOURNAL, 11, 155–163.
2015
- Henkel,M., Zwick,M., Beuker,J., Willenbacher,J., Baumann,S., Oswald,F., Neumann,A., Siemann-Herzberg,M., Syldatk,C. and Hausmann,R. Teaching Bioprocess Engineering to Undergraduates: Multidisciplinary Hands-on Training in a One-Week Practical Course. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 43, 189–202.
- Rimbon,J., Sanchez-Kopper,A., Wahl,A. and Takors,R. Monitoring Intracellular Protein Degradation in Antibody-Producing Chinese Hamster Ovary Cells. ENGINEERING IN LIFE SCIENCES, 15, 499–508.
- Pfizenmaier,J., Matuszczyk,J.-C. and Takors,R. Changes in Intracellular ATP-Content of CHO Cells as Response to Hyperosmolality. BIOTECHNOLOGY PROGRESS, 31, 1212–1216.
- Teleki,A., Sanchez-Kopper,A. and Takors,R. Alkaline Conditions in Hydrophilic Interaction Liquid Chromatography for Intracellular Metabolite Quantification Using Tandem Mass Spectrometry. ANALYTICAL BIOCHEMISTRY, 475, 4–13.
- Vallon,T., Simon,O., Rendgen-Heugle,B., Frana,S., Mueckschel,B., Broicher,A., Siemann-Herzberg,M., Pfannenstiel,J., Hauer,B., Huber,A., et al. Applying Systems Biology Tools to Study N-Butanol Degradation in Pseudomonas Putida KT2440. ENGINEERING IN LIFE SCIENCES, 15, 760–771.
- Lieder,S., Nikel,P.I., de Lorenzo,V. and Takors,R. Genome Reduction Boosts Heterologous Gene Expression in Pseudomonas Putida. MICROBIAL CELL FACTORIES, 14.
- Matuszczyk,J.-C., Teleki,A., Pfizenmaier,J. and Takors,R. Compartment-Specific Metabolomics for CHO Reveals That ATP Pools in Mitochondria Are Much Lower than in Cytosol. BIOTECHNOLOGY JOURNAL, 10, 1639–1650.
2014
- Sudarsan,S., Dethlefsen,S., Blank,L.M., Siemann-Herzberg,M. and Schmid,A. The Functional Structure of Central Carbon Metabolism in Pseudomonas Putida KT2440. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80, 5292–5303.
- Lindner,R., Moosmann,A., Dietrich,A., Boettinger,H., Kontermann,R. and Siemann-Herzberg,M. Process Development of Periplasmatically Produced Single Chain Fragment Variable against Epidermal Growth Factor Receptor in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 192, 136–145.
- Buchholz,J., Graf,M., Freund,A., Busche,T., Kalinowski,J., Blombach,B. and Takors,R. CO2/HCO3 (-) Perturbations of Simulated Large Scale Gradients in a Scale-down Device Cause Fast Transcriptional Responses in Corynebacterium Glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 98, 8563–8572.
- Buchholz,J., Graf,M., Blombach,B. and Takors,R. Improving the Carbon Balance of Fermentations by Total Carbon Analyses. BIOCHEMICAL ENGINEERING JOURNAL, 90, 162–169.
- Gelves,R., Dietrich,A. and Takors,R. Modeling of Gas-Liquid Mass Transfer in a Stirred Tank Bioreactor Agitated by a Rushton Turbine or a New Pitched Blade Impeller. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 37, 365–375.
- Lieder,S., Jahn,M., Seifert,J., von Bergen,M., Mueller,S. and Takors,R. Subpopulation-Proteomics Reveal Growth Rate, but Not Cell Cycling, as a Major Impact on Protein Composition in Pseudomonas Putida KT2440. AMB EXPRESS, 4.
- Schuhmacher,T., Loeffler,M., Hurler,T. and Takors,R. Phosphate Limited Fed-Batch Processes: Impact on Carbon Usage and Energy Metabolism in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 190, 96–104.
2013
- Buchholz,J., Schwentner,A., Brunnenkan,B., Gabris,C., Grimm,S., Gerstmeir,R., Takors,R., Eikmanns,B.J. and Blombach,B. Platform Engineering of Corynebacterium Glutamicum with Reduced Pyruvate Dehydrogenase Complex Activity for Improved Production of L-Lysine, L-Valine, and 2-Ketoisovalerate. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 79, 5566–5575.
- Vallon,T., Glemser,M., Malca,S.H., Scheps,D., Schmid,J., Siemann-Herzberg,M., Hauer,B. and Takors,R. Production of 1-Octanol from n-Octane by Pseudomonas Putida KT2440. CHEMIE INGENIEUR TECHNIK, 85, 841–848.
- Soellner,S., Rahnert,M., Siemann-Herzberg,M., Takors,R. and Altenbuchner,J. Evolution of Pyruvate Kinase-Deficient Escherichia Coli Mutants Enables Glycerol-Based Cell Growth and Succinate Production. JOURNAL OF APPLIED MICROBIOLOGY, 115, 1368–1378.
- Blombach,B., Buchholz,J., Busche,T., Kalinowski,J. and Takors,R. Impact of Different CO2/HCO3- Levels on Metabolism and Regulation in Corynebacterium Glutamicum. JOURNAL OF BIOTECHNOLOGY, 168, 331–340.
2012
- Takors,R. Scale-up of Microbial Processes: Impacts, Tools and Open Questions. JOURNAL OF BIOTECHNOLOGY, 160, 3–9.
2011
- Bongaerts,J., Esser,S., Lorbach,V., Al-Momani,L., Mueller,M.A., Franke,D., Grondal,C., Kurutsch,A., Bujnicki,R., Takors,R., et al. Diversity-Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 7781–7786.
- Wenzel,M., Mueller,A., Siemann-Herzberg,M. and Altenbuchner,J. Self-Inducible Bacillus Subtilis Expression System for Reliable and Inexpensive Protein Production by High-Cell-Density Fermentation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77, 6419–6425.
- Vielhauer,O., Zakhartsev,M., Horn,T., Takors,R. and Reuss,M. Simplified Absolute Metabolite Quantification by Gas Chromatography-Isotope Dilution Mass Spectrometry on the Basis of Commercially Available Source Material. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 879, 3859–3870.
2010
- Schuhmacher,T., Lemuth,K., Hardiman,T., Vacun,G., Reuss,M. and Siemann-Herzberg,M. Quantifying Cytosolic Messenger RNA Concentrations in Escherichia Coli Using Real-Time Polymerase Chain Reaction for a Systems Biology Approach. ANALYTICAL BIOCHEMISTRY, 398, 212–217.
- Canelas,A.B., Harrison,N., Fazio,A., Zhang,J., Pitkanen,J.-P., van den Brink,J., Bakker,B.M., Bogner,L., Bouwman,J., Castrillo,J.I., et al. Integrated Multilaboratory Systems Biology Reveals Differences in Protein Metabolism between Two Reference Yeast Strains. NATURE COMMUNICATIONS, 1.
- Hardiman,T., Meinhold,H., Hofmann,J., Ewald,J.C., Siemann-Herzberg,M. and Reuss,M. Prediction of Kinetic Parameters from DNA-Binding Site Sequences for Modeling Global Transcription Dynamics in Escherichia Coli. METABOLIC ENGINEERING, 12, 196–211.
2009
- Magnus,J.B., Oldiges,M. and Takors,R. The Identification of Enzyme Targets for the Optimization of a Valine Producing Corynebacterium Glutamicum Strain Using a Kinetic Model. BIOTECHNOLOGY PROGRESS, 25, 754–762.
2008
- Lemuth,K., Hardiman,T., Winter,S., Pfeiffer,D., Keller,M.A., Lange,S., Reuss,M., Schmid,R.D. and Siemann-Herzberg,M. Global Transcription and Metabolic Flux Analysis of Escherichia Coli in Glucose-Limited Fed-Batch Cultivations. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74, 7002–7015.
- Hardiman,T., Windeisen,V., Ewald,J.C., Zibek,S., Schlack,P., Rebell,J., Reuss,M. and Siemann-Herzberg,M. In Vitro Synthesis and Characterization of Guanosine 3 `,5 `-Bis(Diphosphate). ANALYTICAL BIOCHEMISTRY, 383, 337–339.
2007
- Noeh,K., Groenke,K., Luo,B., Takors,R., Oldiges,M. and Wiechert,W. Metabolic Flux Analysis at Ultra Short Time Scale: Isotopically Non-Stationary C-13 Labeling Experiments. JOURNAL OF BIOTECHNOLOGY, 129, 249–267.
- Takors,R., Bathe,B., Rieping,M., Hans,S., Kelle,R. and Huthmacher,K. Systems Biology for Industrial Strains and Fermentation Processes - Example: Amino Acids. JOURNAL OF BIOTECHNOLOGY, 129, 181–190.
- van der Werf,M.J., Takors,R., Smedsgaard,J., Nielsen,J., Ferenci,T., Portais,J.C., Wittmann,C., Hooks,M., Tomassini,A., Oldiges,M., et al. Standard Reporting Requirements for Biological Samples in Metabolomics Experiments: Microbial and in Vitro Biology Experiments. METABOLOMICS, 3, 189–194.
- Luo,B., Groenke,K., Takors,R., Wandrey,C. and Oldiges,M. Simultaneous Determination of Multiple Intracellular Metabolites in Glycolysis, Pentose Phosphate Pathway and Tricarboxylic Acid Cycle by Liquid Chromatography-Mass Spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1147, 153–164.
- Hardiman,T., Lemuth,K., Keller,M.A., Reuss,M. and Siemann-Herzberg,M. Topology of the Global Regulatory Network of Carbon Limitation in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 132, 359–374.
2006
- Wahl,S., Takors,R. and Wiechert,W. Interpretation of Metabolic Flux Maps by Limitation Potentials and Constrained Limitation Sensitivities. BIOTECHNOLOGY AND BIOENGINEERING, 94, 263–272.
- Magnus,J.B., Hollwedel,D., Oldiges,M. and Takors,R. Monitoring and Modeling of the Reaction Dynamics in the Valine/Leucine Synthesis Pathway in Corynebacterium Glutamicum. BIOTECHNOLOGY PROGRESS, 22, 1071–1083.
- Franzreb,M., Siemann-Herzberg,M., Hobley,T. and Thomas,O. Protein Purification Using Magnetic Adsorbent Particles. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 70, 505–516.
2005
- Haunschild,M., Freisleben,B., Takors,R. and Wiechert,W. Investigating the Dynamic Behavior of Biochemical Networks Using Model Families. BIOINFORMATICS, 21, 1617–1625.
- Franzreb,M., Ebner,N., Siemann,M., Altenbuchner,J., Fritz,C., Mayer,Z., Schultz,N. and Syldakt,C. Direct Bioproduct Isolation from Crude Feedstocks Using Magnetic Micro Adsorbents. JOURNAL OF BIOTECHNOLOGY, 118, S53.
- Oldiges,M. and Takors,R. Applying Metabolic Profiling Techniques for Stimulus-Response Experiments: Chances and Pitfalls. In TECHNOLOGY TRANSFER IN BIOTECHNOLOGY: FROM LAB TO INDUSTRY TO PRODUCTION, TECHNOLOGY TRANSFER IN BIOTECHNOLOGY: FROM LAB TO INDUSTRY TO PRODUCTION. SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY, Vol. 92, pp. 173–196.
- Franke,G., Stoepel,N., Reidegeld,K., Siemann-Herzberg,M., Reuss,M., Meyer,H. and Warscheid,B. Quantitative Profiling of the Phosphotransferase System in Escherichia Coli. MOLECULAR & CELLULAR PROTEOMICS, 4, S319.
- Ternbach,M., Bollman,C., Wandrey,C. and Takors,R. Application of Model Discriminating Experimental Design for Modeling and Development of a Fermentative Fed-Batch L-Valine Production Process. BIOTECHNOLOGY AND BIOENGINEERING, 91, 356–368.
- Arnold,S., Siemann-Herzberg,M., Schmid,J. and Reuss,M. Model-Based Inference of Gene Expression Dynamics from Sequence Information. In Nielsen, J (ed), BIOTECHNOLOGY FOR THE FUTURE, BIOTECHNOLOGY FOR THE FUTURE. SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY, Vol. 100, pp. 89–179.
2004
- Oldiges,M., Kunze,M., Degenring,D., Sprenger,G. and Takors,R. Stimulation, Monitoring, and Analysis of Pathway Dynamics by Metabolic Profiling in the Aromatic Amino Acid Pathway. BIOTECHNOLOGY PROGRESS, 20, 1623–1633.
- Drysch,A., El Massaoudi,M., Wiechert,W., de Graaf,A. and Takors,R. Serial Flux Mapping of Corynebacterium Glutamicum during Fed-Batch L-Lysine Production Using the Sensor Reactor Approach. BIOTECHNOLOGY AND BIOENGINEERING, 85, 497–505.
- Zelic,B., Gostovic,S., Vuorilehto,K., Vasic-Racki,B. and Takors,R. Process Strategies to Enhance Pyruvate Production with Recombinant Escherichia Coli: From Repetitive Fed-Batch to in Situ Product Recovery with Fully Integrated Electrodialysis. BIOTECHNOLOGY AND BIOENGINEERING, 85, 638–646.
- Takors,R. Complete cell ISPR process development: Chances and risks. CHEMIE INGENIEUR TECHNIK, 76, 1857–1864.
- Ruffer,N., Heidersdorf,U., Kretzers,I., Sprenger,G., Raeven,L. and Takors,R. Fully Integrated L-Phenylalanine Separation and Concentration Using Reactive-Extraction with Liquid-Liquid Centrifuges in a Fed-Batch Process with E-Coli. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 26, 239–248.
- Wahl,A., El Massaoudi,M., Schipper,D., Wiechert,W. and Takors,R. Serial C-13-Based Flux Analysis of an L-Phenylalanine-Producing E-Coli Strain Using the Sensor Reactor. BIOTECHNOLOGY PROGRESS, 20, 706–714.
- Degenring,D., Froemel,C., Dikta,G. and Takors,R. Sensitivity Analysis for the Reduction of Complex Metabolism Models. JOURNAL OF PROCESS CONTROL, 14, 729–745.
- Potter,J. and Siemann,M. A New Method for Determining Delta C-13 and Delta D Simultaneously for CH4 by Gas Chromatography Continuous-Flow Isotope-Ratio Mass Spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 18, 175–180.
- Werner,M., Vazques,F., Fritz,C., Vielhauer,O., Siemann-Herzberg,M., Altenbuchner,J. and Syldatk,C. Cloning of D-Specific Hydantoin Utilization Genes from Arthrobacter Crystallopoietes. ENGINEERING IN LIFE SCIENCES, 4, 563–572.
- Takors,R. Whole Cell ISPR Process Development: Chances and Pitfalls. CHEMIE INGENIEUR TECHNIK, 76, 1807–1814.
- Takors,R. Model-Based Analysis and Optimization of an ISPR Approach Using Reactive Extraction for Pilot-Scale L-Phenylalanine Production. BIOTECHNOLOGY PROGRESS, 20, 57–64.
- Zelic,B., Vasic-Racki,D., Wandrey,C. and Takors,R. Modeling of the Pyruvate Production with Escherichia Coli in a Fed-Batch Bioreactor. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 26, 249–258.
2003
- El Massaoudi,M., Spelthahn,J., Drysch,A., de Graaf,A. and Takors,R. Production Process Monitoring by Serial Mapping of Microbial Carbon Flux Distributions Using a Novel Sensor Reactor Approach: I - Sensor Reactor System. METABOLIC ENGINEERING, 5, 86–95.
- Franke,D., Lorbach,V., Esser,S., Dose,C., Sprenger,G., Halfar,M., Thommes,J., Muller,R., Takors,R. and Muller,M. (S,S)-2,3-Dihydroxy-2,3-Dihydrobenzoic Acid: Microbial Access with Engineered Cells of Escherichia Coli and Application as Starting Material in Natural-Product Synthesis. CHEMISTRY-A EUROPEAN JOURNAL, 9, 4188–4196.
- Drysch,A., El Massaoudi,M., Mack,C., Takors,R., de Graaf,A. and Sahm,H. Production Process Monitoring by Serial Mapping of Microbial Carbon Flux Distributions Using a Novel Sensor Reactor Approach: II - C-13-Labeling-Based Metabolic Flux Analysis and L-Lysine Production. METABOLIC ENGINEERING, 5, 96–107.
- Zelic,B., Gerharz,T., Bott,M., Vasic-Racki,D., Wandrey,C. and Takors,R. Fed-Batch Process for Pyruvate Production by Recombinant Escherichia Coli YYC202 Strain. ENGINEERING IN LIFE SCIENCES, 3, 299–305.
- Oelschlaeger,P., Lange,S., Schmitt,J., Siemann,M., Reuss,M. and Schmid,R. Identification of Factors Impeding the Production of a Single-Chain Antibody Fragment in Escherichia Coli by Comparing in Vivo and in Vitro Expression. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 61, 123–132.
2002
- Gerigk,M., Maass,D., Kreutzer,A., Sprenger,G., Bongaerts,J., Wubbolts,M. and Takors,R. Enhanced Pilot-Scale Fed-Batch L-Phenylalanine Production with Recombinant Escherichia Coli by Fully Integrated Reactive Extraction. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 25, 43–52.
- Abendroth,J., Niefind,K., May,O., Siemann,M., Syldatk,C. and Schomburg,D. The Structure of L-Hydantoinase from Arthobacter Aurescens Leads to an Understanding of Dihydropyrimidinase Substrate and Enantio Specificity. BIOCHEMISTRY, 41, 8589–8597.
- Maass,D., Gerigk,M., Kreutzer,A., Weuster-Botz,D., Wubbolts,M. and Takors,R. Integrated L-Phenylalanine Separation in an E-Coli Fed-Batch Process: from Laboratory to Pilot Scale. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 25, 85–96.
- Schmitz,M., Hirsch,E., Bongaerts,J. and Takors,R. Pulse Experiments as a Prerequisite for the Quantification of in Vivo Enzyme Kinetics in Aromatic Amino Acid Pathway of Escherichia Coli. BIOTECHNOLOGY PROGRESS, 18, 935–941.
- Gerigk,M., Bujnicki,R., Ganpo-Nkwenkwa,E., Bongaerts,J., Sprenger,G. and Takors,R. Process Control for Enhanced L-Phenylalanine Production Using Different Recombinant Escherichia Coli Strains. BIOTECHNOLOGY AND BIOENGINEERING, 80, 746–754.
2001
- Altenbuchner,J., Siemann-Herzberg,M. and Syldatk,C. Hydantoinases and Related Enzymes as Biocatalysts for the Synthesis of Unnatural Chiral Amino Acids. CURRENT OPINION IN BIOTECHNOLOGY, 12, 559–563.
- Wilms,B., Hauck,A., Reuss,M., Syldatk,C., Mattes,R., Siemann,M. and Altenbuchner,J. High-Cell-Density Fermentation for Production of L-N-Carbamoylase Using an Expression System Based on the Escherichia Coli RhaBAD Promoter. BIOTECHNOLOGY AND BIOENGINEERING, 73, 95–103.
- Curvers,S., Linneman,J., Klauser,T., Wandrey,C. and Takors,R. Recombinant Protein Production with Pichia Pastoris in Continuous Fermentation - Kinetic Analysis of Growth and Product Formation. CHEMIE INGENIEUR TECHNIK, 73, 1615–1621.
- Buchholz,A., Takors,R. and Wandrey,C. Quantification of Intracellular Metabolites in Escherichia Coli K12 Using Liquid Chromatographic-Electrospray Ionization Tandem Mass Spectrometric Techniques. ANALYTICAL BIOCHEMISTRY, 295, 129–137.
- Takors,R., Gerigk,M., Paschold,H. and Wandrey,C. Principal-Component Analysis for Microbial L-Phenylalanine Production. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 24, 93–99.
- Arnold,S., Siemann,M., Scharnweber,K., Werner,M., Baumann,S. and Reuss,M. Kinetic Modeling and Simulation of in Vitro Transcription by Phage T7 RNA Polymerase. BIOTECHNOLOGY AND BIOENGINEERING, 72, 548–561.
2000
- Schmitz,G., Franke,D., Stevens,S., Takors,R., Weuster-Botz,D. and Wandrey,C. Regioselective Oxidation of Terfenadine with Cunninghamella Blakesleeana. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 10, 313–324.
- Schindler,P., Baumann,S., Reuss,M. and Siemann,M. In Vitro Coupled Transcription Translation: Effects of Modification in Lysate Preparation on Protein Composition and Biosynthesis Activity. ELECTROPHORESIS, 21, 2606–2609.
1999
- Syldatk,C., May,O., Altenbuchner,J., Mattes,R. and Siemann,M. Microbial Hydantoinases - Industrial Enzymes from the Origin of Life? APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 51, 293–309.
- Siemann,M., Alvarado-Marin,A., Pietzsch,M. and Syldatk,C. A D-Specific Hydantoin Amidohydrolase: Properties of the Metalloenzyme Purified from Arthrobacter Crystallopoietes. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 6, 387–397.
- Schaefer,U., Boos,W., Takors,R. and Weuster-Botz,D. Automated Sampling Device for Monitoring Intracellular Metabolite Dynamics. ANALYTICAL BIOCHEMISTRY, 270, 88–96.
- Schindler,P., Macherhammer,F., Arnold,S., Reuss,M. and Siemann,M. Investigation of Translation Dynamics under Cell-Free Protein Biosynthesis Conditions Using High-Resolution Two-Dimensional Gel Electrophoresis. ELECTROPHORESIS, 20, 806–812.
1998
- May,O., Siemann,M., Siemann,M. and Syldatk,C. Catalytic and Structural Function of Zinc for the Hydantoinase from Arthrobacter Aurescens DSM 3745. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 4, 211–218.
- May,O., Siemann,M., Pietzsch,M., Kiess,M., Mattes,R. and Syldatk,C. Substrate-Dependent Enantioselectivity of a Novel Hydantoinase from Arthrobacter Aurescens DSM 3745: Purification and Characterization as New Member of Cyclic Amidases. JOURNAL OF BIOTECHNOLOGY, 61, 1–13.
- May,O., Siemann,M., Siemann,M. and Syldatk,C. The Hydantoin Amidohydrolase from Arthrobacter Aurescens DSM 3745 Is a Zinc Metalloenzyme. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 5, 367–370.
- May,O., Habenicht,A., Mattes,R., Syldatk,C. and Siemann,M. Molecular Evolution of Hydantoinases. BIOLOGICAL CHEMISTRY, 379, 743–747.
- May,O., Siemann,M. and Syldatk,C. A New Method for the Detection of Hydantoinases with Respect to Their Enantioselectivity on Acrylamide Gels Based on Enzyme Activity Stain. BIOTECHNOLOGY TECHNIQUES, 12, 309–312.
1997
- Siemann,M., Andersson,L. and Mosbach,K. Separation and Detection of Macrolide Antibiotics by HPLC Using Macrolide-Imprinted Synthetic Polymers as Stationary Phases. JOURNAL OF ANTIBIOTICS, 50, 89–91.
- Takors,R., Wiechert,W. and WeusterBotz,D. Experimental Design for the Identification of Macrokinetic Models and Model Discrimination. BIOTECHNOLOGY AND BIOENGINEERING, 56, 564–576.
1996
- May,O., Siemann,M., Syldatk,C., Niefind,K. and Schomburg,D. Crystallization and Preliminary X-Ray Analysis of a Hydantoinase from Arthrobacter Aurescens DSM 3745. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 52, 1209–1210.
- Katanaev,V., Spirin,A., Reuss,M. and Siemann,M. Formation of Bacteriophage MS2 Infectious Units in a Cell-Free Translation System. FEBS LETTERS, 397, 143–148.
- Siemann,M., Andersson,L. and Mosbach,K. Selective Recognition of the Herbicide Atrazine by Noncovalent Molecularly Imprinted Polymers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 44, 141–145.
1994
- SIEMANN,M., SYLDATK,C. and WAGNER,F. ENHANCED STABILITY OF AN L-HYDANTOINASE MEDIATED BY ITS CORRESPONDING POLYCLONAL ANTIBODY. BIOTECHNOLOGY LETTERS, 16, 349–354.
1993
- SIEMANN,M., SYLDATK,C. and WAGNER,F. DETECTION AND COMPARISON OF STRAINS WITH SELECTIVE L-HYDANTOIN CLEAVING ACTIVITY USING POLYCLONAL ANTIBODIES. BIOTECHNOLOGY TECHNIQUES, 7, 361–366.
- SIEMANN,M., SYLDATK,C. and WAGNER,F. CHARACTERIZATION OF SEROLOGICAL PROPERTIES OF POLYCLONAL ANTIBODIES PRODUCED AGAINST ENZYMES INVOLVED IN THE L-SELECTIVE CLEAVAGE OF HYDANTOIN DERIVATIVES. BIOTECHNOLOGY LETTERS, 15, 1–6.
2018
- Barbosa,S., Niebel,B., Wolf,S., Mauch,K. and Takors,R. (2018) A Guide to Gene Regulatory Network Interference for Obtaining Predictive Solutions: Underlying Assumptions and Fundamental Biological and Data Constraints. BioSystems, 174, 37–48.
- Schwentner,A., Feith,A., Münch,E., Busche,T., Rückert,C., Kalinowskis,J., Takors,R. and Blombach,B. (2018) Metabolic Engineering to Guide Evolution - Creating a Novel Mode for L-Valine Production with Corynebacterium Glutamicum. Metabolic Engineering, 47, 31–41.
2017
- Wolf,S., Barbosa,S., Bücher,J. and Takors,R. (2017) Automatic Network Generation Describes Differential Gene Data in User Friendly and Expeditiously Analyzable Network Views. 2, 1–14.
- Pfreundt,U., Spungin,D., Hou,S., Voß,B., Berman-Frank,I. and Hess,W.R. (2017) Genome of a Giant Bacteriophage from a Decaying Trichodesmium Bloom. Marine Genomics, 33, 21–25.
- Kuschel,M., Siebler,F. and Takors,R. (2017) Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors. Bioengineering, 4, 27.
- Hellmers,F., Takors,R. and Thum,O. (2017) Robust Enzyme Immobilizates for Industrial Isomalt Production. Molecular Catalysis, 445, 293–298.
2016
- Sudarsan,S., Blank,L.M., Dietrich,A., Vielhauer,O., Takors,R., Schmid,A. and Reuss,M. (2016) Dynamics of Benzoate Metabolism in Pseudomonas Putida KT2440. Metabolic Engineering Communications, 3, 97–110.
- Álvarez,D., Voß,B., Maass,D., Wüst,F., Schaub,P., Beyer,P. and Welsch,R. (2016) 5’UTR-Mediated Translational Control of Splice Variants of Phytoene Synthase. Plant Physiol.
- Stazic,D. and Voß,B. (2016) The Complexity of Bacterial Transcriptomes. Journal of Biotechnology, 232, 69--78.
- Schäfer,R.A. and Voß,B. (2016) VisualGraphX: Interactive Graph Visualization within Galaxy. Bioinformatics, 10.1093/bioinformatics/btw414.
2015
- Kopf,M., Klähn,S., Scholz,I., Hess,W.R. and Voß,B. (2015) Variations in the Non-Coding Transcriptome as a Driver of Inter-Strain Divergence and Physiological Adaptation in Bacteria. Scientific Reports, 5.
- Blombach,B. and Takors,R. (2015) CO2 - Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes. Front Bioeng Biotechnol, 3, 108.
- Lott,S.C., Voß,B., Hess,W.R. and Steglich,C. (2015) CoVennTree: A New Method for the Comparative Analysis of Large Datasets. Bioinformatics and Computational Biology, 6, 43.
2014
- Kopf,M., Klähn,S., Pade,N., Weingärtner,C., Hagemann,M., Voß,B. and Hess,W.R. (2014) Comparative Genome Analysis of the Closely Related Synechocystis Strains PCC 6714 and PCC 6803. DNA Research, 21, 255--266.
- Kopf,M., Klähn,S., Voß,B., Stüber,K., Huettel,B., Reinhardt,R. and Hess,W.R. (2014) Finished Genome Sequence of the Unicellular Cyanobacterium Synechocystis Sp. Strain PCC 6714. Genome Announcements, 2, e00757--14.
- Voß,B. and Hess,W.R. (2014) The Identification of Bacterial Non-Coding RNAs through Complementary Approaches. In Handbook of RNA Biochemistry, Handbook of RNA Biochemistry. WILEY-VCH, Weinheim, Germany, Vol. 2, pp. 787--800.
- Rogato,A., Richard,H., Sarazin,A., Voß,B., Navarro,S.C., Champeimont,R., Navarro,L., Carbone,A., Hess,W.R. and Falciatore,A. (2014) The Diversity of Small Non-Coding RNAs in the Diatom Phaeodactylum Tricornutum. BMC Genomics, 15, 698.