List of IBVT related publications


  1. 2023

    1. Wild,M., Mast,Y. and Takors,R. (2023) Revisiting Basics of KLa Dependency on Aeration in Bubble Columns: A Is Surprisingly Stable. Chemie Ingenieur Technik, 95, 1–8.
    2. Ulmer,A.U., Veit,S., Erdemann,F., Freund,A., Loesch,M., Teleki,A., Zeidan,A.A. and Takors,R. (2023) A Two‐Compartment Fermentation System to Quantify Strain‐Specific Interactions in Microbial Co‐Cultures. Bioengineering, 10.
  2. 2022

    1. Minden,S., Aniolek,M., Noorman,H. and Takors,R. (2022) Performing in Spite of Starvation: How Saccharomyces Cerevisiae Maintains Robust Growth When Facing Famine Zones in Industrial Bioreactors. Microbial Biotechnology, 16, 148--168.
    2. Minden,S., Aniolek,M., Hajian,C.S.S., Teleki,A., Zerrer,T., Delvigne,F., van Gulik,W., Deshmukh,A., Noorman,H. and Takors,R. (2022) Monitoring Intracellular Metabolite Dynamics in Saccharomyces Cerevisiae during Industrially Relevant Famine Stimuli. metabolites, 12.
    3. Rehnert,M. and Takors,R. (2022) FAIR Research Data Management as Community Approach in Bioengineering. Engineering in Life Science, DOI: 10.1002/elsc.202200005.
    4. Hildenbrand,J.C., Sprenger,G.A., Teleki,A., Takors,R. and Jendrossek,D. (2022) Polyphosphate Kinases Phosphorylate Thiamine Phosphates. Microbial Physiology.
    5. Gaugler,L., Mast,Y., Fitschen,J., Hofmann,S., Schlüter,M. and Takors,R. (2022) Scaling-down Biopharmaceutical Production Processes via a Single Multi-Compartment Bioreactor (SMCB). Engineering in life sciences, DOI: 10.1002/elsc.202100161.
    6. Müller,T., Schick,S., Beck,J., Sprenger,G. and Takors,R. (2022) Synthetic Mutualism in Engineered E. Coli Mutant Strains as Functional Basis for Microbial Production Consortia. Engineering in Life Science,
    7. Ulmer,A., Erdemann,F., Mueller,S., Loesch,M., Wildt,S., Jensen,M.L., Gaspar,P., Zeidan,A.A. and Takors,R. (2022) Differential Amino Acid Uptake and Depletion In-Cultures and Co-Cultures of Streptococcus Thermophilus and Lactobacillus Delbrueckii Subsp. Bulgaricus in a Novel Semi-Synthetic Medium. microorganisms, 10.
    8. Schmidt,C., Trinkmann,F., Takors,R., Cattaneo,G. and Port,J. (2022) Investigation of Tracer Gas Transport in a New Numerical Model of Lung Acini. Medical & Biological Engineering & Computing.
  3. 2021

    1. Hermann,M., Teleki,A., Weitz,S., Niess,A., Freund,A., Bengelsdorf,F.R., Dürre,P. and Takors,R. (2021) Identifying and Engineering Bottlenecks of Autotrophic Isobutanol Formation in Recombinant C. Ljungdahlii by Systemic Analysis. Frontiers in Bioengineering and Biotechnology, 9.
    2. Weitz,S., Hermann,M., Linder,S., Bengelsdorf,F.R., Takors,R. and Dürre,P. (2021) Isobutanol Production by Autotrophic Acetogenic Bacteria. Frontiers in Bioengineering and Biotechnology, 10.3389/fbio.2021.657253.
    3. Ankenbauer,A., Nithschel,R., Müller,T., Favelli,L., Blombach,B. and Takors,R. (2021) Micro-Aerobic Production of Isobutanol with Engineered Pseudomonas Putida. Engineering in Life Science.
    4. Demling,P., Ankenbauer,A., Klein,B., Noack,S., Tiso,T., Takors,R. and Blank,L.M. (2021) Pseudomonas Putida KT2440 Endures Temporary Oxygen Limitations. Biotechnology and Bioengineering, 10.1002/bit.27938.
    5. Kappelmann,J., Klein,B., Papenfuß,M., Lange,J., Blombach,B., Takors,R., Wiechert,W., Polen,T. and Noack,S. (2021) Comprehensive Analysis of C. Glutamicum Anaplerotic Deletion Mutants Under Defined D-Glucose Conditions. Frontiers in Bioengineering and Biotechnology, 8.
    6. Huang,J. and Voß,B. (2021) Simulation of Folding Kinetics for Aligned RNAs. Genes, 12, 347.
    7. Wijaya,A.W., Verhagen,N., Teleki,A. and Takors,A. (2021) Compartment-Specific 13C Metabolic Flux Analysis Reveals Boosted NADPH Availability Coinciding with Increased Cell-Specific Productivity for IgG1 Producing CHO Cells after MTA Treatment. Engineering in Life Science, 10.1002/elsc.202100057.
    8. Ziegler,M., Hägele,L., Gäbele,T. and Takors,R. (2021) CRISPRi Enables Fast Growth Followed by Stable Aerobic Formation in Escherichia Coli without Auxotrophy. Engineering in Life Science, 10.1002/elsc.202100021.
    9. Schäfer,R.A. and Voß,B. (2021) RNAnue: Efficient Data Analysis for RNA–RNA Interactomics. Nucleic Acids Research, 10.1093/nar/gkab340.
    10. Wijaya,A.W., Ulmer,A., Hundsdorfer,L., Verhagen,N., Teleki,A. and Takors,R. (2021) Compartment‑specific Metabolome Labeling Enables the Identification of Subcellular Fluxes That May Serve as Promising Metabolic Engineering Targets in CHO Cells. Bioprocess and Biosystems Engineering, 10.1007/s00449-021-02628-1.
    11. Perpelea,A., Wijaya,A.W., Martins,L.C., Rippert,D., Klein,M., Angelov,A., Peltonen,K., Teleki,A., Liebl,W., Richard,P., et al. (2021) Towards Valorization of Pectin-Rich Agro-Industrial Residues: Engineering of Saccharomyces Cerevisiae for Co-Fermentation of d-Galacturonic Acid and Glycerol. Metabolic Engineering, 10.1016/j.ymben.2021.10.001.
    12. Wijaya,A.W. and Takors,R. (2021) A Transhydrogenase-like Mechanism in CHO Cells Comprising Concerted Reaction and Mitochondrial Shuttling Activities. Biochemical Engineering Journal, 170.
    13. Märkle,P., Maier,L.-K., Maaß,S., Hirschfeld,C., Bartel,J., Becher,D., Voß,B. and Marchfelder,A. (2021) A Small RNA Is Linking CRISPR-Cas and Zinc Transport. Frontiers in Molecular Biosciences, 8.
    14. Ziegler,M., Zieringer,J., Döring,C.-L., Paul,L., Schaal,C. and Takors,R. (2021) Engineering a Robust Escherichia Coli Chassis and Exploitation for Large-Scale Production Process. Metabolic Engineering, 67, 75–87.
  4. 2020

    1. Kuschel,M. and Takors,R. (2020) Simulated Oxygen and Glucose Gradients as a Prerequisite for predicting Industrial Scale Performance a Priori. Biotechnol. Bioeng., 117, 2760–2770.
    2. Sarkizi Shams Hajian,C., Haringa,C., Noorman,H. and Takors,R. (2020) Predicting By-Product Gradients of Baker’s Yeast at Industrial Scale: A Practical Simulation Approach. Processes, 8.
    3. Hermann,M., Teleki,A., Weitz,S., Niess,A., Freund,A., Bengelsdorf,F.R. and Takors,R. (2020) Electron Availability in CO2, CO and H2 Mixtures Flux Distribution, Energy Management and product Formation in Clostridium Ljungdahlii. Microbial Biotechnology, 10.1111/1751-7915.13625.
    4. Müller,F., Rapp,J., Hacker,A.-L., Feith,A., Takors,R. and Blombach,B. (2020) CO2/HCO3- Accelerates Iron Reduction through Phenolic Compounds. mbio.
    5. Patil,V., Santos,C.N.S., Ajikumar,P.K., Sarria,S. and Takors,R. (2020) Balancing Glucose and Oxygen Uptake Rates to Enable High Amorpha‐4,11‐diene Production in Escherichia Coli via the Methylerythritol Phosphate Pathway. Biotechnol. Bioeng., 10.1002/bit.27655.
    6. Ziegler,M., Zieringer,J. and Takors,R. (2020) Transcriptional Profiling of the Stringent Response Mutant Strain E. Coli SR Reveals Enhanced Robustness to Large-Scale Conditions. microbial biotechnology, 10.1111/1751-7915.13738.
    7. Feith,A., Schwentner,A., Teleki,A., Favilli,L., Blombach,B. and Takors,R. (2020) Streamlining the Analysis of Dynamic 13C-Labeling for the Metabolic Engineering of Corynebacterium Glutamicum as l-Histidine Production Host. Metabolites, 10.
    8. Verhagen,N., Zieringer,J. and Takors,R. (2020) Methylthioadenosine (MTA) Boosts Cell-Specific Productivities of Chinese Hamster Ovary Cultures: Dosage Effects on Proliferation, Cell Cycle and Gene Expression. FEBS Open Bio, 10, 2791–2804.
    9. Verhagen,N., Wijaya,A.W., Teleki,A., Fadhlullah,M., Unsöld,A., Schilling,M., Heinrich,C. and Takors,R. (2020) Comparison of L-Tyrosine Containing Dipeptides Reveals ATP Availability for l-Prolyl-l-Tyrosine in CHO. Engineering in Life Science, 10.1002/elsc.202000017.
    10. Graf,M., Haas,T., Teleki,A., Feith,A., Cerff,M., Wiechert,W., Noeh,K., Busche,T., Kalinowski,J. and Takors,R. (2020) Revisiting the Growth Modulon of Corynebacterium Glutamicum Under Glucose Limited Chemostat. Frontiers in Bioengineering and Biotechnology, 10.3389/fbioe.2020.584614.
    11. Verhagen,N., Teleki,A., Heinrich,C., Schilling,M., Unsoeld,A. and Takors,R. (2020) S-Adenosylmethionine and Methylthioadenosine Boost Cellular Productivities of Antibody Forming Chinese Hamster Ovary Cells. Biotechnol. Bioeng., 10.1002/bit.27484.
    12. Müller,J., Siemann-Herzberg,M. and Takors,R. (2020) Modeling Cell-Free Protein Synthesis—Approaches And. Frontiers in Bioengineering and Biotechnology,
    13. Zieringer,J., Wild,M. and Takors,R. (2020) Data‐driven in Silico Prediction of Regulation heterogeneity and ATP Demands of Escherichia Coli in Large‐scale Bioreactors. Biotechnol. Bioeng., 118, 265–278.
    14. Schäfer,R.A., Lott,S.C., Georg,J., Grüning,B.A., Hess,W.R. and Voß,B. (2020) GLASSGo in Galaxy: High-Throughput, Reproducible and Easy-to-Integrate Prediction of SRNA Homologs. Bioinformatics, 10.1093/bioinformatics/btaa556.
  5. 2019

    1. Nieß,A., Siemann-Herzberg,M. and Takors,R. (2019) Protein Production in Escherichia Coli Guided by the Trade‑off between Intracellular Availability and Energy Cost. Microbial Cell Factories, 18.
    2. Grenz,S., Baumann,P.T., Rückert,C., Nebel,B.A., Siebert,D., Schwentner,A., Eikmanns,B.J., Hauer,B., Kalinowsk, i J., Takors,R., et al. (2019) Exploting Hydrogenophage Pseudoflava for Aerobic Syngas-Based Production of Chemicals. Metabolic Engineering, 55, 220–230.
    3. Ziegler,M. and Takors,R. (2019) Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis. In: Minimal Cells: Design, Construction, Biotechnological Applications. In Lara,A.R., Gosset Lagarda,G. (eds).
    4. Haas,T., Graf,M., Nieß,A., Busche,T., Kalinowski,J., Blombach,B. and Takors,T. (2019) Identifying the Growth Modulon of Corynebacterium Glutamicum. Frontiers in Microbiology, 10.
    5. Pobre,V., Graça-Lopes,G., Saramago,M., Ankenbauer,A., Takors,T., Arraiano,C.M. and Viegas,S.C. (2019) Prediction of Novel Non-Coding RNAs Relevant for the Growth of Pseudomonas Putida in a Bioreactor. Microbiology.
    6. Becker,M., Junghans,L., Teleki,A., Bechmann,J. and Takors,R. (2019) Perfusion Cultures Equire Optimum Respiratory ATP Supply to Maximize Cell‐specific and Volumetric Productivities. Biotechnol. Bioeng., 10.1002/bit.26926.
    7. Takors,R. (2019) Biochemical Engineering Provides Mindset, Tools and solutions for the Driving Questions of a Sustainable Future. Engineering in Life Science, 10.1002/elsc.201900150.
    8. Niess,A., Siemann-Herzberg,M. and Takors,R. (2019) Protein Production in Escherichia Coli Is Guided by the Trade-off between Intracellular Substrate Availability and Energy Cost. Microbial Cell Factory, 18.
    9. Becker,M., Junghans,L., Teleki,A., Bechmann,J. and Takors,R. (2019) The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies with Chinese Hamster Ovary Cells. Frontiers in Bioengineering and Biotechnlogy, 7.
    10. Junghans,L., Teleki,A., Wijaya,A., Becker,M., Schweikert,M. and Takors,R. (2019) From Nutrional Wealth to Autophagy: In Vivo Metabolic Dynamics in the Cytosol, Mitochondrion and Shuttles of IgG Producing CHO Cells. Metabolic Engineering, 54, 145–159.
    11. Straathof,A.J.J., Wahl,S.A., Benjamin,K.R., Takors,R., Wierckx,N. and Noorman,H.J. (2019) Grand Research Challenges for Sustainable Industrial Biotechnology. Trends in Biotechnology,
    12. Schwentner,A., Feith,A., Münch,E., Stiefelmaier,J., Lauer,I., Favilli,L., Massner,C., Öhrlein,J., Grund,B., Hüser,A., et al. (2019) Modular Systems Metabolic Engineering Enables Balancing of Relevant Pathways for L-Histidine Production with Corynebacterium Glutamicum. Biotechnology for Biofuels, 12.
    13. Nitschel,R., Ankenbauer,A., Welsch,I., Wirth,N.T., Massner,C., Ahmad,N., McColm,S., Borges,F., Fotheringham,I., Takors,R., et al. (2019) Engineering Pseudomonas Putida KT2440 for the production of Isobutanol. Engineering in Life Science, 20, 148–159.
    14. Graf,M., Haas,T., Müller,F., Buchmann,A., Harm-Betbenbetova,J., Freund,A., Nieß,A., Persicke,M., Kalinowski,J., Blombach,B., et al. (2019) Continuous Adaptive Evolution of a Fast-Growing Corynebacterium Glutamicum Strain Independent of Protocatechuate. Frontiers in Microbiology, 10.3389/fmicb.2019.01648.
  6. 2018

    1. Barbosa,S., Niebel,B., Wolf,S., Mauch,K. and Takors,R. (2018) A Guide to Gene Regulatory Network Interference for Obtaining Predictive Solutions: Underlying Assumptions and Fundamental Biological and Data Constraints. BioSystems, 174, 37–48.
    2. Graf,M., Zieringer,J., Haas,T., Nieß,A., Blombach,B. and Takors,R. (2018) Physiological Response of Corynebacterium Glutamicum to Increasingly Nutrient-Rich Growth Conditions. Frontiers in Microbiology, 9.
    3. Schönberger,B., Schaal,C., Schäfer,R. and Voß,B. (2018) RNA Interactomics: Recent Advances and Remaining Challenges. F1000Research, 7, 1824.
    4. Lange,J., Münch,E., Müller,J., Busche,T., Kalinowski,J., Takors,R. and Blombach,B. (2018) Deciphering the Adaptation of Corynebacterium Glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis. Genes, 9, 297.
    5. Takors,R., Kopf,M., Mampel,J., Bluemke,W., Blombach,B., Eikmanns,B., Bengelsdorf,F.R., Weuster‐Botz,D. and Dürre,P. (2018) Using Gas Mixtures of CO, CO2 and H2 as Microbial Substrates: The Do’s and Don’ts of Successful Technology Transfer from Laboratory to Production Scale. Microbial Biotechnology, 11.
    6. Lott,S.C., Schäfer,R.A., Mann,M., Backofen,R., Hess,W.R., Voß,B. and Georg,J. (2018) GLASSgo - Automated and Reliable Detection of SRNA Homologs from a Single Input Sequence. Frontiers in Genetics, 9.
    7. Zieringer,J. and Takors,R. (2018) In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models. Computational and Structural Biotechnology Journal, 16, 246–256.
    8. Failmezger,J., Scholz,S., Blombach,B. and Siemann-Herzberg,M. (2018) Cell-Free Protein Synthesis From Fast-Growing Vibrio Natriegens. Frontiers in Microbiology, 9.
  7. 2017

    1. Wolf,S., Barbosa,S., Bücher,J. and Takors,R. (2017) Automatic Network Generation Describes Differential Gene Data in User Friendly and Expeditiously Analyzable Network Views. 2, 1–14.
    2. Lange,J., Mueller,F., Bernecker,K., Dahmen,N., Takors,R. and Blombach,B. Valorization of Pyrolysis Water: A Biorefinery Side Stream, for    1,2-Propanediol Production with Engineered Corynebacterium Glutamicum. BIOTECHNOLOGY FOR BIOFUELS, 10.
    3. Niess,A., Loeffler,M., Simen,J.D. and Takors,R. Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce  Long-Term Adaptation of E-Coli Cultures in Large-Scale Bioreactors:    Experimental Evidence and Mathematical Model. FRONTIERS IN MICROBIOLOGY, 8.
    4. Hoffart,E., Grenz,S., Lange,J., Nitschel,R., Mueller,F., Schwentner,A., Feith,A., Lenfers-Luecker,M., Takors,R. and Blombach,B. High Substrate Uptake Rates Empower Vibrio Natriegens as Production Host  for Industrial Biotechnology. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83.
    5. Michalowski,A., Siemann-Herzberg,M. and Takors,R. Escherichia Coli HGT: Engineered for High Glucose Throughput Even under    Slowly Growing or Resting Conditions. METABOLIC ENGINEERING, 40, 93–103.
    6. Delvigne,F., Takors,R., Mudde,R., van Gulik,W. and Noorman,H. Bioprocess Scale-up/down as Integrative Enabling Technology: From Fluid  Mechanics to Systems Biology and Beyond. MICROBIAL BIOTECHNOLOGY, 10, 1267–1274.
    7. Simen,J.D., Loeffler,M., Jaeger,G., Schaeferhoff,K., Freund,A., Matthes,J., Mueller,J., Takors,R. and RecogNice-Team Transcriptional Response of Escherichia Coli to Ammonia and Glucose  Fluctuations. MICROBIAL BIOTECHNOLOGY, 10, 858–872.
    8. Failmezger,J., Ludwig,J., Niess,A. and Siemann-Herzberg,M. Quantifying Ribosome Dynamics in Escherichia Coli Using Fluorescence. FEMS MICROBIOLOGY LETTERS, 364.
    9. Loeffler,M., Simen,J.D., Mueller,J., Jaeger,G., Laghrami,S., Schaeferhoff,K., Freund,A., Takors,R. and RecogNice-Team Switching between Nitrogen and Glucose Limitation: Unraveling  Transcriptional Dynamics in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 258, 2–12.
    10. Teleki,A., Rahnert,M., Bungart,O., Gann,B., Ochrombel,I. and Takors,R. Robust Identification of Metabolic Control for Microbial L-Methionine  Production Following an Easy-to-Use Puristic Approach. METABOLIC ENGINEERING, 41, 159–172.
    11. Eigenstetter,G. and Takors,R. Dynamic Modeling Reveals a Three-Step Response of Saccharomyces  Cerevisiae to High CO2 Levels Accompanied by Increasing ATP Demands. FEMS YEAST RESEARCH, 17.
    12. Niess,A., Failmezger,J., Kuschel,M., Siemann-Herzberg,M. and Takors,R. Experimentally Validated Model Enables Debottlenecking of in Vitro  Protein Synthesis and Identifies a Control Shift under in Vivo  Conditions. ACS SYNTHETIC BIOLOGY, 6, 1913–1921.
    13. Failmezger,J., Rauter,M., Nitschel,R., Kraml,M. and Siemann-Herzberg,M. Cell-Free Protein Synthesis from Non-Growing, Stressed Escherichia Coli. SCIENTIFIC REPORTS, 7.
  8. 2016

    1. Schäfer,R.A. and Voß,B. (2016) VisualGraphX: Interactive Graph Visualization within Galaxy. Bioinformatics, 10.1093/bioinformatics/btw414.
    2. Pfizenmaier,J., Junghans,L., Teleki,A. and Takors,R. Hyperosmotic Stimulus Study Discloses Benefits in ATP Supply and Reveals  MiRNA/MRNA Targets to Improve Recombinant Protein Production of CHO  Cells. BIOTECHNOLOGY JOURNAL, 11, 1037–1047.
    3. Wutz,J., Lapin,A., Siebler,F., Schaefer,J.E., Wucherpfennig,T., Berger,M. and Takors,R. Predictability of k(L)a in Stirred Tank Reactors under Multiple  Operating Conditions Using an Euler-Lagrange Approach. ENGINEERING IN LIFE SCIENCES, 16, 633–642.
    4. Failmezger,J., Nitschel,R., Sanchez-Kopper,A., Kraml,M. and Siemann-Herzberg,M. Site-Specific Cleavage of Ribosomal RNA in Escherichia Coli-Based  Cell-Free Protein Synthesis Systems. PLoS One, 11.
    5. Sudarsan,S., Blank,L.M., Dietrich,A., Vielhauer,O., Takors,R., Schmid,A. and Reuss,M. (2016) Dynamics of Benzoate Metabolism in Pseudomonas Putida KT2440. Metabolic Engineering Communications, 3, 97–110.
    6. Álvarez,D., Voß,B., Maass,D., Wüst,F., Schaub,P., Beyer,P. and Welsch,R. (2016) 5’UTR-Mediated Translational Control of Splice Variants of Phytoene Synthase. Plant Physiol.
    7. Stazic,D. and Voß,B. (2016) The Complexity of Bacterial Transcriptomes. Journal of Biotechnology, 232, 69--78.
    8. Takors,R. and de Lorenzo,V. Editorial Overview: Microbial Systems Biology: Systems Biology Prepares  the Ground for Successful Synthetic Biology. CURRENT OPINION IN MICROBIOLOGY, 33, VIII–X.
    9. Junghans,L., Teleki,A., Becker,M. and Takors,R. LC-MS-Based Compartment-Specific Metabolome Analysis in CHO. NEW BIOTECHNOLOGY, 33, S33–S34.
    10. Takors,R. Editorial: How Can We Ensure the Successful Transfer from Lab- to    Large-Scale Production? ENGINEERING IN LIFE SCIENCES, 16, 587.
    11. Loeffler,M., Simen,J.D., Jaeger,G., Schaeferhoff,K., Freund,A. and Takors,R. Engineering E-Coli for Large-Scale Production - Strategies Considering  ATP Expenses and Transcriptional Responses. METABOLIC ENGINEERING, 38, 73–85.
  9. 2015

    1. Pfizenmaier,J., Matuszczyk,J.-C. and Takors,R. Changes in Intracellular ATP-Content of CHO Cells as Response to    Hyperosmolality. BIOTECHNOLOGY PROGRESS, 31, 1212–1216.
    2. Teleki,A., Sanchez-Kopper,A. and Takors,R. Alkaline Conditions in Hydrophilic Interaction Liquid Chromatography for    Intracellular Metabolite Quantification Using Tandem Mass Spectrometry. ANALYTICAL BIOCHEMISTRY, 475, 4–13.
    3. Vallon,T., Simon,O., Rendgen-Heugle,B., Frana,S., Mueckschel,B., Broicher,A., Siemann-Herzberg,M., Pfannenstiel,J., Hauer,B., Huber,A., et al. Applying Systems Biology Tools to Study N-Butanol Degradation in    Pseudomonas Putida KT2440. ENGINEERING IN LIFE SCIENCES, 15, 760–771.
    4. Blombach,B. and Takors,R. (2015) CO2 - Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes. Front Bioeng Biotechnol, 3, 108.
    5. Rimbon,J., Sanchez-Kopper,A., Wahl,A. and Takors,R. Monitoring Intracellular Protein Degradation in Antibody-Producing  Chinese Hamster Ovary Cells. ENGINEERING IN LIFE SCIENCES, 15, 499–508.
    6. Matuszczyk,J.-C., Teleki,A., Pfizenmaier,J. and Takors,R. Compartment-Specific Metabolomics for CHO Reveals That ATP Pools in    Mitochondria Are Much Lower than in Cytosol. BIOTECHNOLOGY JOURNAL, 10, 1639–1650.
    7. Henkel,M., Zwick,M., Beuker,J., Willenbacher,J., Baumann,S., Oswald,F., Neumann,A., Siemann-Herzberg,M., Syldatk,C. and Hausmann,R. Teaching Bioprocess Engineering to Undergraduates: Multidisciplinary  Hands-on Training in a One-Week Practical Course. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 43, 189–202.
    8. Kopf,M., Klähn,S., Scholz,I., Hess,W.R. and Voß,B. (2015) Variations in the Non-Coding Transcriptome as a Driver of Inter-Strain Divergence and Physiological Adaptation in Bacteria. Scientific Reports, 5.
    9. Lieder,S., Nikel,P.I., de Lorenzo,V. and Takors,R. Genome Reduction Boosts Heterologous Gene Expression in Pseudomonas  Putida. MICROBIAL CELL FACTORIES, 14.
  10. 2014

    1. Giegerich,R. and Voß,B. (2014) RNA Secondary Structure Analysis Using Abstract Shapes. In Handbook of RNA Biochemistry, Handbook of RNA Biochemistry. WILEY-VCH, Weinheim, Germany, Vol. 2, pp. 579--594.
    2. Kopf,M., Klähn,S., Pade,N., Weingärtner,C., Hagemann,M., Voß,B. and Hess,W.R. (2014) Comparative Genome Analysis of the Closely Related Synechocystis Strains PCC 6714 and PCC 6803. DNA Research, 21, 255--266.
    3. Kopf,M., Klähn,S., Voß,B., Stüber,K., Huettel,B., Reinhardt,R. and Hess,W.R. (2014) Finished Genome Sequence of the Unicellular Cyanobacterium Synechocystis Sp. Strain PCC 6714. Genome Announcements, 2, e00757--14.
    4. Buchholz,J., Graf,M., Blombach,B. and Takors,R. Improving the Carbon Balance of Fermentations by Total Carbon Analyses. BIOCHEMICAL ENGINEERING JOURNAL, 90, 162–169.
    5. Schuhmacher,T., Loeffler,M., Hurler,T. and Takors,R. Phosphate Limited Fed-Batch Processes: Impact on Carbon Usage and Energy  Metabolism in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 190, 96–104.
    6. Voigt,K., Sharma,C.M., Mitschke,J., Joke Lambrecht,S., Voß,B., Hess,W.R. and Steglich,C. (2014) Comparative Transcriptomics of Two Environmentally Relevant Cyanobacteria Reveals Unexpected Transcriptome Diversity. The ISME Journal, 10.1038/ismej.2014.57.
    7. Lieder,S., Jahn,M., Seifert,J., von Bergen,M., Mueller,S. and Takors,R. Subpopulation-Proteomics Reveal Growth Rate, but Not Cell Cycling, as a    Major Impact on Protein Composition in Pseudomonas Putida KT2440. AMB EXPRESS, 4.
    8. Sudarsan,S., Dethlefsen,S., Blank,L.M., Siemann-Herzberg,M. and Schmid,A. The Functional Structure of Central Carbon Metabolism in Pseudomonas  Putida KT2440. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80, 5292–5303.
    9. Buchholz,J., Graf,M., Freund,A., Busche,T., Kalinowski,J., Blombach,B. and Takors,R. CO2/HCO3 (-) Perturbations of Simulated Large Scale Gradients in a    Scale-down Device Cause Fast Transcriptional Responses in    Corynebacterium Glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 98, 8563–8572.
    10. Gelves,R., Dietrich,A. and Takors,R. Modeling of Gas-Liquid Mass Transfer in a Stirred Tank Bioreactor  Agitated by a Rushton Turbine or a New Pitched Blade Impeller. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 37, 365–375.
    11. Rogato,A., Richard,H., Sarazin,A., Voß,B., Navarro,S.C., Champeimont,R., Navarro,L., Carbone,A., Hess,W.R. and Falciatore,A. (2014) The Diversity of Small Non-Coding RNAs in the Diatom Phaeodactylum Tricornutum. BMC Genomics, 15, 698.
    12. Bischler,T., Kopf,M. and Voß,B. (2014) Transcript Mapping Based on DRNA-Seq Data. BMC Bioinformatics, 15, 122.
    13. Huang,J. and Voß,B. (2014) Analysing RNA-Kinetics Based on Folding Space Abstraction. BMC Bioinformatics, 15, 60.
    14. Kopf,M., Klähn,S., Scholz,I., Matthiessen,J.K.F., Hess,W.R. and Voß,B. (2014) Comparative Analysis of the Primary Transcriptome of Synechocystis Sp. PCC 6803. DNA Research, 21, 527--539.
    15. Lindner,R., Moosmann,A., Dietrich,A., Boettinger,H., Kontermann,R. and Siemann-Herzberg,M. Process Development of Periplasmatically Produced Single Chain Fragment  Variable against Epidermal Growth Factor Receptor in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 192, 136–145.
    16. Voß,B. and Hess,W.R. (2014) The Identification of Bacterial Non-Coding RNAs through Complementary Approaches. In Handbook of RNA Biochemistry, Handbook of RNA Biochemistry. WILEY-VCH, Weinheim, Germany, Vol. 2, pp. 787--800.
  11. 2013

    1. Buchholz,J., Schwentner,A., Brunnenkan,B., Gabris,C., Grimm,S., Gerstmeir,R., Takors,R., Eikmanns,B.J. and Blombach,B. Platform Engineering of Corynebacterium Glutamicum with Reduced Pyruvate  Dehydrogenase Complex Activity for Improved Production of L-Lysine,    L-Valine, and 2-Ketoisovalerate. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 79, 5566–5575.
    2. Vallon,T., Glemser,M., Malca,S.H., Scheps,D., Schmid,J., Siemann-Herzberg,M., Hauer,B. and Takors,R. Production of 1-Octanol from n-Octane by Pseudomonas Putida KT2440. CHEMIE INGENIEUR TECHNIK, 85, 841–848.
    3. Soellner,S., Rahnert,M., Siemann-Herzberg,M., Takors,R. and Altenbuchner,J. Evolution of Pyruvate Kinase-Deficient Escherichia Coli Mutants Enables  Glycerol-Based Cell Growth and Succinate Production. JOURNAL OF APPLIED MICROBIOLOGY, 115, 1368–1378.
    4. Hein,S., Scholz,I., Voß,B. and Hess,W.R. (2013) Adaptation and Modification of Three CRISPR Loci in Two Closely Related Cyanobacteria. RNA Biology, 10, 93--92.
  12. 2012

    1. Madhugiri,R., Pessi,G., Voß,B., Hahn,J., Sharma,C.M., Reinhardt,R., Vogel,J., Hess,W.R., Fischer,H.-M. and Evguenieva-Hackenberg,E. (2012) Small RNAs of the Bradyrhizobium/Rhodopseudomonas Lineage and Their Analysis. RNA Biology, 9, 45--56.
    2. Huang,J., Backofen,R. and Voß,B. (2012) Abstract Folding Space Analysis Based on Helices. RNA, 18, 2135--2147.
    3. Gierga,G., Voß,B. and Hess,W.R. (2012) Non-Coding RNAs in Marine Synechococcus and Their Regulation under Environmentally Relevant Stress Conditions. The ISME Journal, 6, 1544--1557.
    4. Trautmann,D., Voß,B., Wilde,A., Al-Babili,S. and Hess,W.R. (2012) Microevolution in Cyanobacteria: Re-Sequencing a Motile Substrain of Synechocystis Sp. PCC 6803. DNA Research, 10.1093/dnares/dss024.
    5. Takors,R. Scale-up of Microbial Processes: Impacts, Tools and Open Questions. JOURNAL OF BIOTECHNOLOGY, 160, 3–9.
  13. 2011

    1. Babski,J., Tjaden,B., Voß,B., Jellen-Ritter,A., Marchfelder,A., Hess,W.R. and Soppa,J. (2011) Bioinformatic Prediction and Experimental Verification of SRNAs in the Haloarchaeon Haloferax Volcanii. RNA Biology, 8, 806--816.
    2. Mitschke,J., Georg,J., Scholz,I., Sharma,C.M., Dienst,D., Bantscheff,J., Voß,B., Steglich,C., Wilde,A., Vogel,J., et al. (2011) An Experimentally Anchored Map of Transcriptional Start Sites in the Model Cyanobacterium Synechocystis Sp. PCC6803. Proceedings of the National Academy of Sciences, 108, 2124--2129.
    3. Wenzel,M., Mueller,A., Siemann-Herzberg,M. and Altenbuchner,J. Self-Inducible Bacillus Subtilis Expression System for Reliable and    Inexpensive Protein Production by High-Cell-Density Fermentation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77, 6419–6425.
    4. Bongaerts,J., Esser,S., Lorbach,V., Al-Momani,L., Mueller,M.A., Franke,D., Grondal,C., Kurutsch,A., Bujnicki,R., Takors,R., et al. Diversity-Oriented Production of Metabolites Derived from Chorismate and    Their Use in Organic Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 7781–7786.
  14. 2010

    1. Hardiman,T., Meinhold,H., Hofmann,J., Ewald,J.C., Siemann-Herzberg,M. and Reuss,M. Prediction of Kinetic Parameters from DNA-Binding Site Sequences for    Modeling Global Transcription Dynamics in Escherichia Coli. METABOLIC ENGINEERING, 12, 196–211.
    2. Canelas,A.B., Harrison,N., Fazio,A., Zhang,J., Pitkanen,J.-P., van den Brink,J., Bakker,B.M., Bogner,L., Bouwman,J., Castrillo,J.I., et al. Integrated Multilaboratory Systems Biology Reveals Differences in    Protein Metabolism between Two Reference Yeast Strains. NATURE COMMUNICATIONS, 1.
    3. Schuhmacher,T., Lemuth,K., Hardiman,T., Vacun,G., Reuss,M. and Siemann-Herzberg,M. Quantifying Cytosolic Messenger RNA Concentrations in Escherichia Coli  Using Real-Time Polymerase Chain Reaction for a Systems Biology Approach. ANALYTICAL BIOCHEMISTRY, 398, 212–217.
    4. Voß,B., Meinecke,L., Kurz,T., Al-Babili,S., Beck,C.F. and Hess,W.R. (2010) Hemin and Mg-Protoporphyrin IX Induce Global Changes in Gene Expression in Chlamydomonas Reinhardtii. Plant Physiol., 10.1104/pp.110.158683.
    5. Bogomolov,S., Mann,M., Voß,B., Podelski,A. and Backofen,R. (2010) Shape-Based Barrier Estimation for RNAs. In In Proceedings of German Conference on Bioinformatics GCB’10, In Proceedings of German Conference on Bioinformatics GCB’10. GI, Vol. 173, pp. 42--51.
    6. Ionescu,D., Voß,B., Oren,A., Hess,W.R. and Muro-Pastor,A.M. (2010) Heterocyst-Specific Transcription of NsiR1, a Non-Coding RNA Encoded in a Tandem Array of Direct Repeats in Cyanobacteria. Journal of Molecular Biology, 398, 177--188.
  15. 2009

    1. Magnus,J.B., Oldiges,M. and Takors,R. The Identification of Enzyme Targets for the Optimization of a Valine  Producing Corynebacterium Glutamicum Strain Using a Kinetic Model. BIOTECHNOLOGY PROGRESS, 25, 754–762.
    2. Voß,B., Hölscher,M., Baumgarth,B., Kalbfleisch,A., Kaya,C., Hess,W.R., Becker,A. and Elena Evguenieva-Hackenberg (2009) Expression of Small RNAs in Rhizobiales and Protection of a Small RNA and Its Degradation Products by Hfq in Sinorhizobium Meliloti. Biochemical and Biophysical Research Communications, 390, 331--336.
    3. Georg,J., Voß,B., Scholz,I., Mitschke,J., Wilde,A. and Hess,W.R. (2009) Evidence for a Major Role of Antisense RNAs in Cyanobacterial Gene Regulation. Mol Syst Biol, 5.
    4. Voß,B., Georg,J., Schon,V., Ude,S. and Hess,W. (2009) Biocomputational Prediction of Non-Coding RNAs in Model Cyanobacteria. BMC Genomics, 10, 123.
    5. Gierga,G., Voß,B. and Hess,W.R. (2009) The Yfr2 NcRNA Family, a Group of Abundant RNA Molecules Widely Conserved in Cyanobacteria. RNA Biology, 6, 222--227.
  16. 2008

    1. Hardiman,T., Windeisen,V., Ewald,J.C., Zibek,S., Schlack,P., Rebell,J., Reuss,M. and Siemann-Herzberg,M. In Vitro Synthesis and Characterization of Guanosine 3 `,5  `-Bis(Diphosphate). ANALYTICAL BIOCHEMISTRY, 383, 337–339.
    2. Lemuth,K., Hardiman,T., Winter,S., Pfeiffer,D., Keller,M.A., Lange,S., Reuss,M., Schmid,R.D. and Siemann-Herzberg,M. Global Transcription and Metabolic Flux Analysis of Escherichia Coli in    Glucose-Limited Fed-Batch Cultivations. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74, 7002–7015.
    3. Steglich,C., Futschik,M.E., Lindell,D., Voß,B., Chisholm,S.W. and Hess,W.R. (2008) The Challenge of Regulation in a Minimal Photoautotroph: Non-Coding RNAs in Prochlorococcus. PLoS Genet, 4, e1000173.
  17. 2007

    1. van der Werf,M.J., Takors,R., Smedsgaard,J., Nielsen,J., Ferenci,T., Portais,J.C., Wittmann,C., Hooks,M., Tomassini,A., Oldiges,M., et al. Standard Reporting Requirements for Biological Samples in Metabolomics  Experiments: Microbial and in Vitro Biology Experiments. METABOLOMICS, 3, 189–194.
    2. Hardiman,T., Lemuth,K., Keller,M.A., Reuss,M. and Siemann-Herzberg,M. Topology of the Global Regulatory Network of Carbon Limitation in    Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 132, 359–374.
    3. Luo,B., Groenke,K., Takors,R., Wandrey,C. and Oldiges,M. Simultaneous Determination of Multiple Intracellular Metabolites in    Glycolysis, Pentose Phosphate Pathway and Tricarboxylic Acid Cycle by    Liquid Chromatography-Mass Spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1147, 153–164.
    4. Noeh,K., Groenke,K., Luo,B., Takors,R., Oldiges,M. and Wiechert,W. Metabolic Flux Analysis at Ultra Short Time Scale: Isotopically  Non-Stationary C-13 Labeling Experiments. JOURNAL OF BIOTECHNOLOGY, 129, 249–267.
    5. Chen,X.H., Koumoutsi,A., Scholz,R., Eisenreich,A., Schneider,K., Heinemeyer,I., Morgenstern,B., Voß,B., Hess,W.R., Reva,O., et al. (2007) Comparative Analysis of the Complete Genome Sequence of the Plant Growth-Promoting Bacterium Bacillus Amyloliquefaciens FZB42. Nat Biotech, 25, 1007--1014.
    6. Takors,R., Bathe,B., Rieping,M., Hans,S., Kelle,R. and Huthmacher,K. Systems Biology for Industrial Strains and Fermentation Processes -    Example: Amino Acids. JOURNAL OF BIOTECHNOLOGY, 129, 181–190.
    7. Axmann,I.M., Holtzendorff,J., Voß,B., Kensche,P. and Hess,W.R. (2007) Two Distinct Types of 6S RNA in Prochlorococcus. Gene, 406, 69--78.
    8. Fattash,I., Voß,B., Reski,R., Hess,W. and Frank,W. (2007) Evidence for the Rapid Expansion of MicroRNA-Mediated Regulation in Early Land Plant Evolution. BMC Plant Biology, 7, 13.
    9. Voß,B., Gierga,G., Axmann,I. and Hess,W. (2007) A Motif-Based Search in Bacterial Genomes Identifies the Ortholog of the Small RNA Yfr1 in All Lineages of Cyanobacteria. BMC Genomics, 8, 375.
  18. 2006

    1. Voß,B., Giegerich,R. and Rehmsmeier,M. (2006) Complete Probabilistic Analysis of RNA Shapes. BMC Biology, 4, 5.
    2. Reeder,J., Höchsmann,M., Rehmsmeier,M., Voß,B. and Giegerich,R. (2006) Beyond Mfold: Recent Advances in RNA Bioinformatics. Journal of Biotechnology, 124, 41--55.
    3. Franzreb,M., Siemann-Herzberg,M., Hobley,T. and Thomas,O. Protein Purification Using Magnetic Adsorbent Particles. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 70, 505–516.
    4. Magnus,J.B., Hollwedel,D., Oldiges,M. and Takors,R. Monitoring and Modeling of the Reaction Dynamics in the Valine/Leucine  Synthesis Pathway in Corynebacterium Glutamicum. BIOTECHNOLOGY PROGRESS, 22, 1071–1083.
    5. Wahl,S., Takors,R. and Wiechert,W. Interpretation of Metabolic Flux Maps by Limitation Potentials and    Constrained Limitation Sensitivities. BIOTECHNOLOGY AND BIOENGINEERING, 94, 263–272.
    6. Talmor-Neiman,M., Stav,R., Frank,W., Voß,B. and Arazi,T. (2006) Novel Micro-RNAs and Intermediates of Micro-RNA Biogenesis from Moss. The Plant Journal, 47, 25--37.
    7. Steffen,P., Voß,B., Rehmsmeier,M., Reeder,J. and Giegerich,R. (2006) RNAshapes: An Integrated RNA Analysis Package Based on Abstract Shapes. Bioinformatics, 22, 500--503.
  19. 2005

    1. Franke,G., Stoepel,N., Reidegeld,K., Siemann-Herzberg,M., Reuss,M., Meyer,H. and Warscheid,B. Quantitative Profiling of the Phosphotransferase System in Escherichia  Coli. MOLECULAR & CELLULAR PROTEOMICS, 4, S319.
    2. Voß,B. (2005) Advanced Tools for RNA Secondary Structure Analysis.
    3. Franzreb,M., Ebner,N., Siemann,M., Altenbuchner,J., Fritz,C., Mayer,Z., Schultz,N. and Syldakt,C. Direct Bioproduct Isolation from Crude Feedstocks Using Magnetic Micro  Adsorbents. JOURNAL OF BIOTECHNOLOGY, 118, S53.
    4. Haunschild,M., Freisleben,B., Takors,R. and Wiechert,W. Investigating the Dynamic Behavior of Biochemical Networks Using Model  Families. BIOINFORMATICS, 21, 1617–1625.
  20. 2004

    1. Wahl,A., El Massaoudi,M., Schipper,D., Wiechert,W. and Takors,R. Serial C-13-Based Flux Analysis of an L-Phenylalanine-Producing E-Coli  Strain Using the Sensor Reactor. BIOTECHNOLOGY PROGRESS, 20, 706–714.
    2. Werner,M., Vazques,F., Fritz,C., Vielhauer,O., Siemann-Herzberg,M., Altenbuchner,J. and Syldatk,C. Cloning of D-Specific Hydantoin Utilization Genes from Arthrobacter  Crystallopoietes. ENGINEERING IN LIFE SCIENCES, 4, 563–572.
    3. Ruffer,N., Heidersdorf,U., Kretzers,I., Sprenger,G., Raeven,L. and Takors,R. Fully Integrated L-Phenylalanine Separation and Concentration Using  Reactive-Extraction with Liquid-Liquid Centrifuges in a Fed-Batch  Process with E-Coli. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 26, 239–248.
    4. Oldiges,M., Kunze,M., Degenring,D., Sprenger,G. and Takors,R. Stimulation, Monitoring, and Analysis of Pathway Dynamics by Metabolic  Profiling in the Aromatic Amino Acid Pathway. BIOTECHNOLOGY PROGRESS, 20, 1623–1633.
    5. Zelic,B., Gostovic,S., Vuorilehto,K., Vasic-Racki,B. and Takors,R. Process Strategies to Enhance Pyruvate Production with Recombinant  Escherichia Coli: From Repetitive Fed-Batch to in Situ Product Recovery  with Fully Integrated Electrodialysis. BIOTECHNOLOGY AND BIOENGINEERING, 85, 638–646.
    6. Drysch,A., El Massaoudi,M., Wiechert,W., de Graaf,A. and Takors,R. Serial Flux Mapping of Corynebacterium Glutamicum during Fed-Batch  L-Lysine Production Using the Sensor Reactor Approach. BIOTECHNOLOGY AND BIOENGINEERING, 85, 497–505.
    7. Potter,J. and Siemann,M. A New Method for Determining Delta C-13 and Delta D Simultaneously for    CH4 by Gas Chromatography Continuous-Flow Isotope-Ratio Mass  Spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 18, 175–180.
    8. Giegerich,R., Voß,B. and Rehmsmeier,M. (2004) Abstract Shapes of RNA. Nucl. Acids Res., 32, 4843--4851.
    9. Höchsmann,M., Voß,B. and Giegerich,R. (2004) Pure Multiple RNA Secondary Structure Alignments: A Progressive Profile Approach. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 1, 53--62.
    10. Takors,R. Complete cell ISPR process development: Chances and risks. CHEMIE INGENIEUR TECHNIK, 76, 1857–1864.
    11. Degenring,D., Froemel,C., Dikta,G. and Takors,R. Sensitivity Analysis for the Reduction of Complex Metabolism Models. JOURNAL OF PROCESS CONTROL, 14, 729–745.
  21. 2003

    1. Drysch,A., El Massaoudi,M., Mack,C., Takors,R., de Graaf,A. and Sahm,H. Production Process Monitoring by Serial Mapping of Microbial Carbon Flux  Distributions Using a Novel Sensor Reactor Approach: II -    C-13-Labeling-Based Metabolic Flux Analysis and L-Lysine Production. METABOLIC ENGINEERING, 5, 96–107.
    2. Zelic,B., Gerharz,T., Bott,M., Vasic-Racki,D., Wandrey,C. and Takors,R. Fed-Batch Process for Pyruvate Production by Recombinant Escherichia  Coli YYC202 Strain. ENGINEERING IN LIFE SCIENCES, 3, 299–305.
    3. El Massaoudi,M., Spelthahn,J., Drysch,A., de Graaf,A. and Takors,R. Production Process Monitoring by Serial Mapping of Microbial Carbon Flux  Distributions Using a Novel Sensor Reactor Approach: I - Sensor Reactor  System. METABOLIC ENGINEERING, 5, 86–95.
    4. Franke,D., Lorbach,V., Esser,S., Dose,C., Sprenger,G., Halfar,M., Thommes,J., Muller,R., Takors,R. and Muller,M. (S,S)-2,3-Dihydroxy-2,3-Dihydrobenzoic Acid: Microbial Access with    Engineered Cells of Escherichia Coli and Application as Starting  Material in Natural-Product Synthesis. CHEMISTRY-A EUROPEAN JOURNAL, 9, 4188–4196.
  22. 2002

    1. Gerigk,M., Maass,D., Kreutzer,A., Sprenger,G., Bongaerts,J., Wubbolts,M. and Takors,R. Enhanced Pilot-Scale Fed-Batch L-Phenylalanine Production with    Recombinant Escherichia Coli by Fully Integrated Reactive Extraction. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 25, 43–52.
    2. Schmitz,M., Hirsch,E., Bongaerts,J. and Takors,R. Pulse Experiments as a Prerequisite for the Quantification of in Vivo  Enzyme Kinetics in Aromatic Amino Acid Pathway of Escherichia Coli. BIOTECHNOLOGY PROGRESS, 18, 935–941.
    3. Buchholz,A., Hurlebaus,J., Wandrey,C. and Takors,R. (2002) Metabolomics: Quantification of Intracellular Metabolite Dynamics. Biomol. Eng., 19, 5–15.
    4. Abendroth,J., Niefind,K., May,O., Siemann,M., Syldatk,C. and Schomburg,D. The Structure of L-Hydantoinase from Arthobacter Aurescens Leads to an    Understanding of Dihydropyrimidinase Substrate and Enantio Specificity. BIOCHEMISTRY, 41, 8589–8597.
    5. Maass,D., Gerigk,M., Kreutzer,A., Weuster-Botz,D., Wubbolts,M. and Takors,R. Integrated L-Phenylalanine Separation in an E-Coli Fed-Batch Process:    from Laboratory to Pilot Scale. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 25, 85–96.
    6. Hurlebaus,J., Buchholz,A., Alt,W., Wiechert,W. and Takors,R. (2002) MMT – A Pathway Modeling Tool for Data From Rapid Sampling Experiments. In Silico Biology, 2, 467–484.
  23. 2001

    1. Altenbuchner,J., Siemann-Herzberg,M. and Syldatk,C. Hydantoinases and Related Enzymes as Biocatalysts for the Synthesis of    Unnatural Chiral Amino Acids. CURRENT OPINION IN BIOTECHNOLOGY, 12, 559–563.
    2. Buchholz,A., Takors,R. and Wandrey,C. Quantification of Intracellular Metabolites in Escherichia Coli K12  Using Liquid Chromatographic-Electrospray Ionization Tandem Mass  Spectrometric Techniques. ANALYTICAL BIOCHEMISTRY, 295, 129–137.
    3. Curvers,S., Linneman,J., Klauser,T., Wandrey,C. and Takors,R. Recombinant Protein Production with Pichia Pastoris in Continuous  Fermentation - Kinetic Analysis of Growth and Product Formation. CHEMIE INGENIEUR TECHNIK, 73, 1615–1621.
    4. Wilms,B., Hauck,A., Reuss,M., Syldatk,C., Mattes,R., Siemann,M. and Altenbuchner,J. High-Cell-Density Fermentation for Production of L-N-Carbamoylase Using  an Expression System Based on the Escherichia Coli RhaBAD Promoter. BIOTECHNOLOGY AND BIOENGINEERING, 73, 95–103.
    5. Thömmes,J., Halfar,M., Gieren,H., Curvers,S., Takors,R., Brunschier,R. and Kula,M.R. (2001) Human Chymotrypsinogen B Production with Pichia Pastoris by Integrated Fermentation and Downstream Processing Part II: Protein Recovery. Biotechnol. Prog, 17, 503–512.
    6. Takors,R., Gerigk,M., Paschold,H. and Wandrey,C. Principal-Component Analysis for Microbial L-Phenylalanine Production. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 24, 93–99.
  24. 2000

    1. Schmitz,G., Franke,D., Stevens,S., Takors,R., Weuster-Botz,D. and Wandrey,C. Regioselective Oxidation of Terfenadine with Cunninghamella Blakesleeana. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 10, 313–324.
    2. Dilsen,S., Paul,W., Sandgathe,A., Tippe,D., Freudl,R., Thömmes,J., Kula,M.R., Takors,R., Wandrey,C. and Weuster-Botz,D. (2000) Fed-Batch Production of Recombinant Human Calcitonin Precursor Fusion-Protein Using Staphylococcus Carnosus as Expression-Sectretion System. Appl. Microbiol. Biotechnol., 54, 361–369.
  25. 1999

    1. Schindler,P., Macherhammer,F., Arnold,S., Reuss,M. and Siemann,M. Investigation of Translation Dynamics under Cell-Free Protein  Biosynthesis Conditions Using High-Resolution Two-Dimensional Gel  Electrophoresis. ELECTROPHORESIS, 20, 806–812.
    2. Schaefer,U., Boos,W., Takors,R. and Weuster-Botz,D. Automated Sampling Device for Monitoring Intracellular Metabolite  Dynamics. ANALYTICAL BIOCHEMISTRY, 270, 88–96.
    3. Siemann,M., Alvarado-Marin,A., Pietzsch,M. and Syldatk,C. A D-Specific Hydantoin Amidohydrolase: Properties of the Metalloenzyme  Purified from Arthrobacter Crystallopoietes. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 6, 387–397.
    4. Syldatk,C., May,O., Altenbuchner,J., Mattes,R. and Siemann,M. Microbial Hydantoinases - Industrial Enzymes from the Origin of Life? APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 51, 293–309.
  26. 1998

    1. May,O., Siemann,M., Siemann,M. and Syldatk,C. The Hydantoin Amidohydrolase from Arthrobacter Aurescens DSM 3745 Is a    Zinc Metalloenzyme. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 5, 367–370.
    2. May,O., Habenicht,A., Mattes,R., Syldatk,C. and Siemann,M. Molecular Evolution of Hydantoinases. BIOLOGICAL CHEMISTRY, 379, 743–747.
    3. May,O., Siemann,M., Pietzsch,M., Kiess,M., Mattes,R. and Syldatk,C. Substrate-Dependent Enantioselectivity of a Novel Hydantoinase from    Arthrobacter Aurescens DSM 3745: Purification and Characterization as    New Member of Cyclic Amidases. JOURNAL OF BIOTECHNOLOGY, 61, 1–13.
    4. May,O., Siemann,M., Siemann,M. and Syldatk,C. Catalytic and Structural Function of Zinc for the Hydantoinase from    Arthrobacter Aurescens DSM 3745. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 4, 211–218.
  27. 1997

    1. Siemann,M., Andersson,L. and Mosbach,K. Separation and Detection of Macrolide Antibiotics by HPLC Using  Macrolide-Imprinted Synthetic Polymers as Stationary Phases. JOURNAL OF ANTIBIOTICS, 50, 89–91.
  28. 1996

    1. May,O., Siemann,M., Syldatk,C., Niefind,K. and Schomburg,D. Crystallization and Preliminary X-Ray Analysis of a Hydantoinase from    Arthrobacter Aurescens DSM 3745. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 52, 1209–1210.
    2. Katanaev,V., Spirin,A., Reuss,M. and Siemann,M. Formation of Bacteriophage MS2 Infectious Units in a Cell-Free  Translation System. FEBS LETTERS, 397, 143–148.
  29. 1994

  30. 1993

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