Microbial Strain Engineering

Novel Chassis for Production

Chassis Engineering

Cells that are exposed to industrial scale conditions frequently face stress that initiates long lasting regulatory programs. Although meaningful in natural habitats, related responses only create additional metabolic and energetic burden in large production processes. Consequently, research at IBVT focuses on eliminating said non-necessary cellular responses to create robust chassis for dedicated large-scale performance on advanced levels.

Engineering Producer Strains

Applying tools of systems metabolic engineering and synthetic biology novel microbial production strains are engineered, in agreement with the goals of IBVT. As a special feature, automated strain engineering is emphasized. In essence, the conventional design-build-test-learn cycle is enriched by novel developments of hybrid learning integrating in-house developments for cellular models. Such twins not only integrate ‘lessons learned’ but also guide future strain engineering.

Current microbial strain engineering predominately focusses on prokaryotes.


This image shows Ralf Takors

Ralf Takors

Prof. Dr.-Ing.


Anina Buchmann

Dr. rer. nat.

Former Postdoctoral Researcher

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