Biochemical Engineering

Based on Systems Metabolic Engineering & Synthetic Biology

The biochemical engineering activities are deeply rooted in systems metabolic engineering by applying and developing relevant tools. Moreover, synthetic biology tools are used to create novel production platforms for large-scale application.


Modeling is the enabling technology that structures knowledge and allows quantitative prediction of subcellular, cellular, and inter-cellular dynamics as an essential building block of strain and process engineering. As such, modelling activities are key for scale-up and strain engineering.

Examples of additional modeling studies are:


    Advanced metabolomics protocols and tools are developed to achieve a quantitative holistic understanding of microbial and mammalian cells eventually enabling systems metabolic engineering and synthetic biology approaches.

    Selection of publications:


      Still, the transfer from lab to production scale is challenging, may decide about economic feasibility and often follows rather heuristic than knowledge-based rules. Accordingly, wet- and dry-lab studies are performed to enable in silico prediction of large-scale performance.

      Selection of publications:

        Strain Engineering

        Studies target creating novel microbial  production platforms  with improved properties for industrial applications. Methods of systems metabolic engineering and synthetic biology are applied.

        Selection of publications:

          Bioprocess Development

          The biochemical engineering studies are deeply rooted in systems metabolic engineering also applying tools of synthetic biology. Accordingly, development of novel processes is always based on profound subcellular analysis and understanding.

          Selection of publications:

            Please Contact

            This image shows Ralf Takors

            Ralf Takors

            Prof. Dr.-Ing.


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