Research at the Institute of Biochemical Engineering (IBVT) focuses on subcellular, cellular and intercellular studies to gain a quantitative understanding of underlying control and regulatory mechanisms in microbial and mammalian cells. Results are used to enable knowledge-based strain and biochemical engineering from the lab to the production scale. Wet- and dry lab tools are developed to ease strain and process engineering. As such, experiments and modelling are intertwined thereby opening the door to the production of novel products using newly created strains with optimized chassis.
Accordingly, research at IBVT links conventional biochemical engineering approaches with the mindset of systems metabolic engineering and synthetic biology. Microbial cells such as Escherichia coli, Pseudomonas putida, Corynebacterium glutamicum, Clostridium ljungdahlii, Vibrio natriegens, yeasts such Saccharomyces cerevisiae, or mammalian cells such as Chinese hamster ovary are typically applied. IBVT offers fermentation capacities up to 300 L scale including downstream processing facilities. Profound metabolomics accompany bioprocess development.
IBVT is closely networked with multiple national and international research groups and companies and a member of the Stuttgart Research Center of Systems Biology, SRCSB.