Modelling of metabolic activities and bioprocesses represents a core activity of IBVT. Biological systems are studied by topology analysis making use of genome-scale stoichiometric networks. These approaches are combined with metabolic flux analysis to study intracellular flux distributions. Using the results of metabolomics, metabolic control analysis is performed to quantify and identify promising metabolic engineering targets for strain improvement. Metabolic studies are completed with related investigations of transcriptional regulation applying bioinformatic tools to decipher regulatory, transcriptional networks. Besides, modelling studies focus on the interaction of large-scale heterogeneities (found in industrial bioreactors) with the metabolic activity of the producers. For this, computational fluid dynamics are combined with mass transfer and metabolic models.