apl. Prof. Dr. habil.

Martin Siemann-Herzberg

apl. Professor/ Vice Director

Contact

0711 685-65161
0711 685-55164

Allmandring 31
70569 Stuttgart
Deutschland
Room: 1.305

Peer-reviewed Journal Publications:
  1. 2019

    1. Niess,A., Siemann-Herzberg,M. and Takors,R. (2019) Protein Production in Escherichia Coli Is Guided by the Trade-off between Intracellular Substrate Availability and Energy Cost. Microbial Cell Factory, 18.
  2. 2018

    1. Failmezger,J., Scholz,S., Blombach,B. and Siemann-Herzberg,M. (2018) Cell-Free Protein Synthesis From Fast-Growing Vibrio Natriegens. Frontiers in Microbiology, 9.
  3. 2017

    1. Failmezger,J., Rauter,M., Nitschel,R., Kraml,M. and Siemann-Herzberg,M. (2017) Cell-Free Protein Synthesis from Non-Growing, Stressed Escherichia Coli. SCIENTIFIC REPORTS, 7.
    2. Failmezger,J., Ludwig,J., Niess,A. and Siemann-Herzberg,M. (2017) Quantifying Ribosome Dynamics in Escherichia Coli Using Fluorescence. FEMS MICROBIOLOGY LETTERS, 364.
    3. Niess,A., Failmezger,J., Kuschel,M., Siemann-Herzberg,M. and Takors,R. (2017) Experimentally Validated Model Enables Debottlenecking of in Vitro  Protein Synthesis and Identifies a Control Shift under in Vivo  Conditions. ACS SYNTHETIC BIOLOGY, 6, 1913–1921.
    4. Michalowski,A., Siemann-Herzberg,M. and Takors,R. (2017) Escherichia Coli HGT: Engineered for High Glucose Throughput Even under    Slowly Growing or Resting Conditions. METABOLIC ENGINEERING, 40, 93–103.
  4. 2016

    1. Failmezger,J., Nitschel,R., Sanchez-Kopper,A., Kraml,M. and Siemann-Herzberg,M. (2016) Site-Specific Cleavage of Ribosomal RNA in Escherichia Coli-Based  Cell-Free Protein Synthesis Systems. PLoS One, 11.
  5. 2015

    1. Henkel,M., Zwick,M., Beuker,J., Willenbacher,J., Baumann,S., Oswald,F., Neumann,A., Siemann-Herzberg,M., Syldatk,C. and Hausmann,R. (2015) Teaching Bioprocess Engineering to Undergraduates: Multidisciplinary  Hands-on Training in a One-Week Practical Course. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 43, 189–202.
    2. Vallon,T., Simon,O., Rendgen-Heugle,B., Frana,S., Mueckschel,B., Broicher,A., Siemann-Herzberg,M., Pfannenstiel,J., Hauer,B., Huber,A., et al. (2015) Applying Systems Biology Tools to Study N-Butanol Degradation in    Pseudomonas Putida KT2440. ENGINEERING IN LIFE SCIENCES, 15, 760–771.
  6. 2014

    1. Lindner,R., Moosmann,A., Dietrich,A., Boettinger,H., Kontermann,R. and Siemann-Herzberg,M. (2014) Process Development of Periplasmatically Produced Single Chain Fragment  Variable against Epidermal Growth Factor Receptor in Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 192, 136–145.
    2. Sudarsan,S., Dethlefsen,S., Blank,L.M., Siemann-Herzberg,M. and Schmid,A. (2014) The Functional Structure of Central Carbon Metabolism in Pseudomonas  Putida KT2440. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80, 5292–5303.
  7. 2013

    1. Soellner,S., Rahnert,M., Siemann-Herzberg,M., Takors,R. and Altenbuchner,J. (2013) Evolution of Pyruvate Kinase-Deficient Escherichia Coli Mutants Enables  Glycerol-Based Cell Growth and Succinate Production. JOURNAL OF APPLIED MICROBIOLOGY, 115, 1368–1378.
    2. Vallon,T., Glemser,M., Malca,S.H., Scheps,D., Schmid,J., Siemann-Herzberg,M., Hauer,B. and Takors,R. (2013) Production of 1-Octanol from n-Octane by Pseudomonas Putida KT2440. CHEMIE INGENIEUR TECHNIK, 85, 841–848.
  8. 2011

    1. Wenzel,M., Mueller,A., Siemann-Herzberg,M. and Altenbuchner,J. (2011) Self-Inducible Bacillus Subtilis Expression System for Reliable and    Inexpensive Protein Production by High-Cell-Density Fermentation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77, 6419–6425.
  9. 2010

    1. Hardiman,T., Meinhold,H., Hofmann,J., Ewald,J.C., Siemann-Herzberg,M. and Reuss,M. (2010) Prediction of Kinetic Parameters from DNA-Binding Site Sequences for    Modeling Global Transcription Dynamics in Escherichia Coli. METABOLIC ENGINEERING, 12, 196–211.
    2. Schuhmacher,T., Lemuth,K., Hardiman,T., Vacun,G., Reuss,M. and Siemann-Herzberg,M. (2010) Quantifying Cytosolic Messenger RNA Concentrations in Escherichia Coli  Using Real-Time Polymerase Chain Reaction for a Systems Biology Approach. ANALYTICAL BIOCHEMISTRY, 398, 212–217.
    3. Canelas,A.B., Harrison,N., Fazio,A., Zhang,J., Pitkanen,J.-P., van den Brink,J., Bakker,B.M., Bogner,L., Bouwman,J., Castrillo,J.I., et al. (2010) Integrated Multilaboratory Systems Biology Reveals Differences in    Protein Metabolism between Two Reference Yeast Strains. NATURE COMMUNICATIONS, 1.
  10. 2008

    1. Lemuth,K., Hardiman,T., Winter,S., Pfeiffer,D., Keller,M.A., Lange,S., Reuss,M., Schmid,R.D. and Siemann-Herzberg,M. (2008) Global Transcription and Metabolic Flux Analysis of Escherichia Coli in    Glucose-Limited Fed-Batch Cultivations. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74, 7002–7015.
    2. Hardiman,T., Windeisen,V., Ewald,J.C., Zibek,S., Schlack,P., Rebell,J., Reuss,M. and Siemann-Herzberg,M. (2008) In Vitro Synthesis and Characterization of Guanosine 3 `,5  `-Bis(Diphosphate). ANALYTICAL BIOCHEMISTRY, 383, 337–339.
  11. 2007

    1. Hardiman,T., Lemuth,K., Keller,M.A., Reuss,M. and Siemann-Herzberg,M. (2007) Topology of the Global Regulatory Network of Carbon Limitation in    Escherichia Coli. JOURNAL OF BIOTECHNOLOGY, 132, 359–374.
  12. 2006

    1. Franzreb,M., Siemann-Herzberg,M., Hobley,T. and Thomas,O. (2006) Protein Purification Using Magnetic Adsorbent Particles. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 70, 505–516.
  13. 2005

    1. Franke,G., Stoepel,N., Reidegeld,K., Siemann-Herzberg,M., Reuss,M., Meyer,H. and Warscheid,B. (2005) Quantitative Profiling of the Phosphotransferase System in Escherichia  Coli. MOLECULAR & CELLULAR PROTEOMICS, 4, S319.
    2. Franzreb,M., Ebner,N., Siemann,M., Altenbuchner,J., Fritz,C., Mayer,Z., Schultz,N. and Syldakt,C. (2005) Direct Bioproduct Isolation from Crude Feedstocks Using Magnetic Micro  Adsorbents. JOURNAL OF BIOTECHNOLOGY, 118, S53.
    3. Arnold,S., Siemann-Herzberg,M., Schmid,J. and Reuss,M. (2005) Model-Based Inference of Gene Expression Dynamics from Sequence  Information. In Nielsen, J (ed), BIOTECHNOLOGY FOR THE FUTURE, BIOTECHNOLOGY FOR THE FUTURE. SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY, Vol. 100, pp. 89–179.
  14. 2004

    1. Potter,J. and Siemann,M. (2004) A New Method for Determining Delta C-13 and Delta D Simultaneously for    CH4 by Gas Chromatography Continuous-Flow Isotope-Ratio Mass  Spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 18, 175–180.
    2. Werner,M., Vazques,F., Fritz,C., Vielhauer,O., Siemann-Herzberg,M., Altenbuchner,J. and Syldatk,C. (2004) Cloning of D-Specific Hydantoin Utilization Genes from Arthrobacter  Crystallopoietes. ENGINEERING IN LIFE SCIENCES, 4, 563–572.
  15. 2003

    1. Oelschlaeger,P., Lange,S., Schmitt,J., Siemann,M., Reuss,M. and Schmid,R. (2003) Identification of Factors Impeding the Production of a Single-Chain  Antibody Fragment in Escherichia Coli by Comparing in Vivo and in Vitro  Expression. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 61, 123–132.
  16. 2002

    1. Abendroth,J., Niefind,K., May,O., Siemann,M., Syldatk,C. and Schomburg,D. (2002) The Structure of L-Hydantoinase from Arthobacter Aurescens Leads to an    Understanding of Dihydropyrimidinase Substrate and Enantio Specificity. BIOCHEMISTRY, 41, 8589–8597.
  17. 2001

    1. Arnold,S., Siemann,M., Scharnweber,K., Werner,M., Baumann,S. and Reuss,M. (2001) Kinetic Modeling and Simulation of in Vitro Transcription by Phage T7  RNA Polymerase. BIOTECHNOLOGY AND BIOENGINEERING, 72, 548–561.
    2. Altenbuchner,J., Siemann-Herzberg,M. and Syldatk,C. (2001) Hydantoinases and Related Enzymes as Biocatalysts for the Synthesis of    Unnatural Chiral Amino Acids. CURRENT OPINION IN BIOTECHNOLOGY, 12, 559–563.
    3. Wilms,B., Hauck,A., Reuss,M., Syldatk,C., Mattes,R., Siemann,M. and Altenbuchner,J. (2001) High-Cell-Density Fermentation for Production of L-N-Carbamoylase Using  an Expression System Based on the Escherichia Coli RhaBAD Promoter. BIOTECHNOLOGY AND BIOENGINEERING, 73, 95–103.
  18. 2000

    1. Schindler,P., Baumann,S., Reuss,M. and Siemann,M. (2000) In Vitro Coupled Transcription Translation: Effects of Modification in    Lysate Preparation on Protein Composition and Biosynthesis Activity. ELECTROPHORESIS, 21, 2606–2609.
  19. 1999

    1. Schindler,P., Macherhammer,F., Arnold,S., Reuss,M. and Siemann,M. (1999) Investigation of Translation Dynamics under Cell-Free Protein  Biosynthesis Conditions Using High-Resolution Two-Dimensional Gel  Electrophoresis. ELECTROPHORESIS, 20, 806–812.
    2. Syldatk,C., May,O., Altenbuchner,J., Mattes,R. and Siemann,M. (1999) Microbial Hydantoinases - Industrial Enzymes from the Origin of Life? APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 51, 293–309.
    3. Siemann,M., Alvarado-Marin,A., Pietzsch,M. and Syldatk,C. (1999) A D-Specific Hydantoin Amidohydrolase: Properties of the Metalloenzyme  Purified from Arthrobacter Crystallopoietes. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 6, 387–397.
  20. 1998

    1. May,O., Siemann,M. and Syldatk,C. (1998) A New Method for the Detection of Hydantoinases with Respect to Their  Enantioselectivity on Acrylamide Gels Based on Enzyme Activity Stain. BIOTECHNOLOGY TECHNIQUES, 12, 309–312.
    2. May,O., Habenicht,A., Mattes,R., Syldatk,C. and Siemann,M. (1998) Molecular Evolution of Hydantoinases. BIOLOGICAL CHEMISTRY, 379, 743–747.
    3. May,O., Siemann,M., Pietzsch,M., Kiess,M., Mattes,R. and Syldatk,C. (1998) Substrate-Dependent Enantioselectivity of a Novel Hydantoinase from    Arthrobacter Aurescens DSM 3745: Purification and Characterization as    New Member of Cyclic Amidases. JOURNAL OF BIOTECHNOLOGY, 61, 1–13.
    4. May,O., Siemann,M., Siemann,M. and Syldatk,C. (1998) The Hydantoin Amidohydrolase from Arthrobacter Aurescens DSM 3745 Is a    Zinc Metalloenzyme. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 5, 367–370.
    5. May,O., Siemann,M., Siemann,M. and Syldatk,C. (1998) Catalytic and Structural Function of Zinc for the Hydantoinase from    Arthrobacter Aurescens DSM 3745. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 4, 211–218.
  21. 1997

    1. Siemann,M., Andersson,L. and Mosbach,K. (1997) Separation and Detection of Macrolide Antibiotics by HPLC Using  Macrolide-Imprinted Synthetic Polymers as Stationary Phases. JOURNAL OF ANTIBIOTICS, 50, 89–91.
  22. 1996

    1. Katanaev,V., Spirin,A., Reuss,M. and Siemann,M. (1996) Formation of Bacteriophage MS2 Infectious Units in a Cell-Free  Translation System. FEBS LETTERS, 397, 143–148.
    2. May,O., Siemann,M., Syldatk,C., Niefind,K. and Schomburg,D. (1996) Crystallization and Preliminary X-Ray Analysis of a Hydantoinase from    Arthrobacter Aurescens DSM 3745. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 52, 1209–1210.
    3. Siemann,M., Andersson,L. and Mosbach,K. (1996) Selective Recognition of the Herbicide Atrazine by Noncovalent  Molecularly Imprinted Polymers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 44, 141–145.
  23. 1994

    1. SIEMANN,M., SYLDATK,C. and WAGNER,F. (1994) ENHANCED STABILITY OF AN L-HYDANTOINASE MEDIATED BY ITS CORRESPONDING  POLYCLONAL ANTIBODY. BIOTECHNOLOGY LETTERS, 16, 349–354.
  24. 1993

    1. SIEMANN,M., SYLDATK,C. and WAGNER,F. (1993) DETECTION AND COMPARISON OF STRAINS WITH SELECTIVE L-HYDANTOIN CLEAVING  ACTIVITY USING POLYCLONAL ANTIBODIES. BIOTECHNOLOGY TECHNIQUES, 7, 361–366.
    2. SIEMANN,M., SYLDATK,C. and WAGNER,F. (1993) CHARACTERIZATION OF SEROLOGICAL PROPERTIES OF POLYCLONAL ANTIBODIES  PRODUCED AGAINST ENZYMES INVOLVED IN THE L-SELECTIVE CLEAVAGE OF    HYDANTOIN DERIVATIVES. BIOTECHNOLOGY LETTERS, 15, 1–6.
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