This image shows Ralf Takors

Ralf Takors

Prof. Dr.-Ing.

Professor

Contact

+49 711 685 64535
 +49 711 685 55164
Business card (VCF)

Allmandring 31
70569 Stuttgart
Deutschland
Room: 1.305

Office Hours

On demand, arrangement via secretary (Ms. Reu).

Subject

My key research interest is to understand metabolism and regulation of microbial and mammalian cells in depth, thereby enabling model-based strain and process engineering finally to transfer novel bioprocesses from lab to industrial scale. As such, research activities are rooted in modern biochemical engineering closely following the mindset of systems metabolic engineering and also using tools of synthetic biology.

Peer Reviewed Journal Publications:

  1. 2025

    1. 168.
      Puiman, Lars ; Bokelmann, Carolin ; Simpson, Sean D ; Spormann, Alfred M ; Takors, Ralf: Dos and don’ts for scaling up gas fermentations. In: Current Opinion in Biotechnology (2025)
    2. 167.
      Spindler, Jan ; Giakissiklis, Christina ; Stierle, Catharina ; Buschlüter, Marc ; Liebeton, Klaus ; Siemann-Herzberg, Martin ; Takors, Ralf: Mechanistic Modeling of In Vivo Translation in Escherichia coli Reliably Identifies Well-Adapted and Optimized RNA Sequences. In: ACS Synthetic Biology (2025)
    3. 166.
      Kienzle, Samuel ; Junghans, Lisa ; Wieschalka, Stefan ; Diem, Katharina ; Takors, Ralf ; Radde, Nicole Erika ; Kunzelmann, Marco ; Presser, Beate ; u. a.: Direct Consideration of Process History During Intensified Design of Experiments Planning Eases Interpretation of Mammalian Cell Culture Dynamics. In: Bioengineering (2025)
    4. 165.
      Mast, Yannic ; Ghaderi, Adel ; Takors, Ralf: Real Case Study of 600 m3 Bubble Column Fermentations: Spatially Resolved Simulations Unveil Optimization Potentials for l‐Phenylalanine Production With Escherichia coli. In: Biotechnology and Bioengineering (2025)
    5. 164.
      Takors, Ralf: Food for Thoughts for Prospective Biomanufacturing. In: Microbial Biotechnology (2025)

  2. 2024

    1. 163.
      Castillo‐Saldarriaga, Carlos ; Santos, Christine N. S. ; Sarria, Stephen ; Ajikumar, Parayil K. ; Takors, Ralf: Substitute Yeast Extract While Maintaining Performance: Showcase Amorpha‐4,11‐Diene Production. In: Microbial Biotechnology (2024)
    2. 162.
      Cordell, William ; Avolio, Gennaro ; Takors, Ralf ; Pfleger, Brian F.: Genome reduction improves octanoic acid production in scale down bioreactors. In: Microbial Biotechnology (2024)
    3. 161.
      Bokelmann, Carolin ; Bromley, Jason ; Takors, Ralf: Pros and cons of airlift and bubble column bioreactors: How internals improve performance. In: Biochemical Engineering Journal (2024)
    4. 160.
      Schick, Simon ; Müller, Tobias ; Takors, Ralf ; Sprenger, Georg: Stability of a Mutualistic <i>Escherichia coli</i> Co‐Culture During Violacein Production Depends on the Kind of Carbon Source. In: Engineering in Life Sciences (2024)
    5. 159.
      Hägele, Lorena ; Pfleger, Brian F. ; Takors, Ralf: Getting the Right Clones in an Automated Manner: An Alternative to Sophisticated Colony-Picking Robotics. In: Bioengineering (2024)
    6. 158.
      Castillo-Saldarriaga, Carlos ; Sarria, Stephen ; Santos, Christine N.S. ; Ajikumar, Parayil K. ; Takors, Ralf: Semi-continuous biomanufacturing for maximizing the production of complex chemicals and fuels: a case study of amorpha-4,11-diene. In: Trends in Biotechnology (2024)
    7. 157.
      Hofmann, Sebastian ; Buntkiel, Lukas ; Rautenbach, Ryan ; Gaugler, Lena ; Ma, Yifan ; Haase, Ingrid ; Fitschen, Jürgen ; Wucherpfennig, Thomas ; u. a.: Experimental analysis of lifelines in a 15,000 L bioreactor by means of Lagrangian Sensor Particles. In: Chemical Engineering Research and Design (2024)
    8. 156.
      Müller, Tobias ; Schick, Simon ; Klemp, Jan-Simon ; Sprenger, Georg A. ; Takors, Ralf: Synthetic co-culture in an interconnected two-compartment bioreactor system: violacein production with recombinant E. coli strains. In: Bioprocess and Biosystems Engineering (2024)
    9. 155.
      Gaugler, Lena ; Hofmann, Sebastian ; Schlüter, Michael ; Takors, Ralf: Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior. In: Biotechnology and Bioengineering (2024)
    10. 154.
      Notheisen, Jan ; Takors, Ralf: Reactive extraction of pyridinedicarboxylic acid (PDCA) with tri-n-octylamine and Aliquat 336 in 1-octanol – A promising approach to access microbially produced PDCA. In: Separation and Purification Technology (2024)
    11. 153.
      Harting, Claudia ; Teleki, Attila ; Braakmann, Marius ; Jankowitsch, Frank ; Takors, Ralf: Systemic intracellular analysis for balancing complex biosynthesis in a transcriptionally deregulated Escherichia colil‐Methionine producer. In: Microbial Biotechnology (2024)
    12. 152.
      Mast, Yannic ; Takors, Ralf: Novel experimental data-driven bubble breakage model for universal application in Euler-Lagrange multiphase frameworks. In: Chemical Engineering Science (2024)
    13. 151.
      Föller, Stefanie ; Regett, Niklas Regett ; Lataster, Levin ; Radziwill, Gerald ; Takors, Ralf: Optimum blue light exposure: a means to increase cell‑specific productivity in Chinese hamster ovary cells. In: Applied Microbiology & Biotechnology (2024)

  3. 2023

    1. 150.
      Mast, Yannic ; Wild, Moritz ; Takors, Ralf: Optimizing Mass Transfer in Multiphase Fermentation: The Role of Drag Models and Physical Conditions. In: Processes (2023)
    2. 149.
      Matamouros, Susana ; Gensch, Thomas ; Cerff, Martin ; Sachs, Christian C. ; Abdollahzadeh, Iman ; Hendriks, Johnny ; Horst, Lucas ; Tenhaef, Niklas ; u. a.: Growth-rate dependency of ribosome abundance and translation elongation rate in Corynebacterium glutamicum differs from that in Escherichia coli. In: Nature Communications Bd. 14, Springer Science and Business Media LLC (2023)
    3. 148.
      Bendig, Tamara ; Ulmer, Andreas ; Luzia, Laura ; Müller, Susanne ; Sahle, Sven ; Bergmann, Frank T. ; Lösch, Maren ; Erdemann, Florian ; u. a.: The pH-dependent lactose metabolism of Lactobacillus delbrueckii subsp. bulgaricus: An integrative view through a mechanistic computational model. In: Journal of Biotechnology Bd. 374, Elsevier BV (2023), S. 90–100
    4. 147.
      Minden, Steven ; Aniolek, Maria ; Noorman, Henk ; Takors, Ralf: Performing in spite of starvation: How Saccharomyces cerevisiae maintains robust growth when facing famine zones in industrial bioreactors. In: Microbial Biotechnology (2023)
    5. 146.
      Wild, Moritz ; Mast, Yannic ; Takors, Ralf: Revisiting Basics of kLa Dependency on Aeration in Bubble Columns: a Is Surprisingly Stable. In: Chemie Ingenieur Technik Bd. 95 (2023), S. 1–8
    6. 145.
      Werner, Felix ; Schwardmann, Lynn S. ; Siebert, Daniel ; Rückert‑Reed, Christian ; Kalinowski, Jörn ; Wirth, Marie‑Theres ; Hofer, Katharina ; Takors, Ralf ; u. a.: Metabolic engineering of Corynebacterium glutamicum for fatty alcohol production from glucose and wheat straw hydrolysate. In: Biotechnology for Biofuels and Bioproducts Bd. 16 (2023)
    7. 144.
      Cordell, William T ; Avolio, Gennaro ; Takors, Ralf ; Pfleger, Brian F: Milligrams to kilograms: making microbes work at scale. In: TIBTEC (2023)
    8. 143.
      Minden, Steven ; Aniolek, Maria ; Noorman, Henk ; Takors, Ralf: Mimicked Mixing-Induced Heterogeneities of Industrial Bioreactors Stimulate Long-Lasting Adaption Programs in Ethanol-Producing Yeasts. In: genes Bd. 14 (2023)
    9. 142.
      Mast, Yannic ; Takors, Ralf: Transferring Bubble Breakage Models Tailored for Euler-Euler Approaches to Euler-Lagrange Simulations. In: processes Bd. 11 (2023), S. 1–22
    10. 141.
      Lataster, Levin ; Huber, Hanna Mereth ; Böttcher, Christina ; Föller, Stefanie ; Takors, Ralf ; Radziwill, Gerald: Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein p21. In: Biology Bd. 12 (2023)
    11. 140.
      Pfleger, Brian F ; Takors, Ralf: Recent progress in the synthesis of advanced biofuel and bioproducts. In: Current Opinion in Biotechnology Bd. 80 (2023), S. 1–10
    12. 139.
      Ulmer, Andreas ; Veit, Stefan ; Erdemann, Florian ; Freund, Andreas ; Loesch, Maren ; Teleki, Attila ; Zeidan, Ahmad A. ; Takors, Ralf: A Two‐Compartment Fermentation System to Quantify Strain‐Specific Interactions in Microbial Co‐Cultures. In: Bioengineering Bd. 10 (2023)

  4. 2022

    1. 138.
      Hildenbrand, Jennie C. ; Sprenger, Georg A. ; Teleki, Attila ; Takors, Ralf ; Jendrossek, Dieter: Polyphosphate Kinases Phosphorylate Thiamine Phosphates. In: Microbial Physiology, S. Karger AG (2022), S. 1–11
    2. 137.
      Rehnert, Martina ; Takors, Ralf: FAIR research data management as community approach in bioengineering. In: Engineering in Life Science (2022)
    3. 136.
      Müller, Tobias ; Schick, Simon ; Beck, Jonathan ; Sprenger, Georg ; Takors, Ralf: Synthetic mutualism in engineered E. coli mutant strains as functional basis for microbial production consortia. In: Engineering in Life Science (2022), S. 1–14
    4. 135.
      Gaugler, Lena ; Mast, Yannic ; Fitschen, Jürgen ; Hofmann, Sebastian ; Schlüter, Michael ; Takors, Ralf: Scaling-down biopharmaceutical production processes via a single multi-compartment bioreactor (SMCB). In: Engineering in life sciences (2022)
    5. 134.
      Ulmer, Andreas ; Erdemann, Florian ; Mueller, Susanne ; Loesch, Maren ; Wildt, Sandy ; Jensen, Maiken Lund ; Gaspar, Paula ; Zeidan, Ahmad A ; u. a.: Differential Amino Acid Uptake and Depletion in Mono-Cultures and Co-Cultures of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus in a Novel Semi-Synthetic Medium. In: microorganisms Bd. 10 (2022)
    6. 133.
      Minden, Steven ; Aniolek, Maria ; Hajian, Christopher Sarkizi Shams ; Teleki, Attila ; Zerrer, Tobias ; Delvigne, Frank ; van Gulik, Walter ; Deshmukh, Amit ; u. a.: Monitoring Intracellular Metabolite Dynamics in Saccharomyces cerevisiae during Industrially Relevant Famine Stimuli. In: metabolites Bd. 12 (2022)
    7. 132.
      Schmidt, Christoph ; Trinkmann, Frederik ; Takors, Ralf ; Cattaneo, Giorgio ; Port, Johannes: Investigation of tracer gas transport in a new numerical model of lung acini. In: Medical & Biological Engineering & Computing (2022)

  5. 2021

    1. 131.
      Demling, Philipp ; Ankenbauer, Andreas ; Klein, Bianca ; Noack, Stephan ; Tiso, Till ; Takors, Ralf ; Blank, Lars M.: Pseudomonas putida KT2440 endures temporary oxygen limitations. In: Biotechnology and Bioengineering (2021)
    2. 130.
      Hermann, Maria ; Teleki, Attila ; Weitz, Sandra ; Niess, Alexander ; Freund, Andreas ; Bengelsdorf, Frank Robert ; Dürre, Peter ; Takors, Ralf: Identifying and Engineering Bottlenecks of Autotrophic Isobutanol Formation in Recombinant C. ljungdahlii by Systemic Analysis. In: Frontiers in Bioengineering and Biotechnology Bd. 9, Frontiers Media SA (2021)
    3. 129.
      Wijaya, A.W. ; Ulmer, A. ; Hundsdorfer, L. ; Verhagen, N. ; Teleki, A. ; Takors, R.: Compartment‑specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising metabolic engineering targets in CHO cells. In: Bioprocess and Biosystems Engineering (2021)
    4. 128.
      Perpelea, A. ; Wijaya, A.W. ; Martins, L.C. ; Rippert, D. ; Klein, M. ; Angelov, A. ; Peltonen, K. ; Teleki, A. ; u. a.: Towards valorization of pectin-rich agro-industrial residues: Engineering of Saccharomyces cerevisiae for co-fermentation of d-galacturonic acid and glycerol. In: Metabolic Engineering (2021)
    5. 127.
      Ziegler, M. ; Zieringer, J. ; Döring, C.-L. ; Paul, L. ; Schaal, C. ; Takors, R.: Engineering a robust Escherichia coli chassis and exploitation for large-scale production process. In: Metabolic Engineering Bd. 67 (2021), S. 75–87
    6. 126.
      Kappelmann, Jannick ; Klein, Bianca ; Papenfuß, Mathias ; Lange, Julian ; Blombach, Bastian ; Takors, Ralf ; Wiechert, Wolfgang ; Polen, Tino ; u. a.: Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined D-Glucose Conditions. In: Frontiers in Bioengineering and Biotechnology Bd. 8 (2021)
    7. 125.
      Wijaya, Andy Wiranata ; Takors, Ralf: A transhydrogenase-like mechanism in CHO cells comprising concerted cytosolic reaction and mitochondrial shuttling activities. In: Biochemical Engineering Journal Bd. 170 (2021)
    8. 124.
      Weitz, S. ; Hermann, M. ; Linder, S. ; Bengelsdorf, F.R. ; Takors, R. ; Dürre, P.: Isobutanol Production by Autotrophic Acetogenic Bacteria. In: Frontiers in Bioengineering and Biotechnology (2021)
    9. 123.
      Ziegler, Martin ; Hägele, Lorena ; Gäbele, Teresa ; Takors, Ralf: CRISPRi enables fast growth followed by stable aerobic pyruvate formation in Escherichia coli without auxotrophy. In: Engineering in Life Science (2021)
    10. 122.
      Wijaya, A.W. ; Verhagen, N. ; Teleki, A. ; Takors, A.: Compartment-specific 13C metabolic flux analysis reveals boosted NADPH availability coinciding with increased cell-specific productivity for IgG1 producing CHO cells after MTA treatment. In: Engineering in Life Science (2021)
    11. 121.
      Ankenbauer, Andreas ; Nithschel, Robert ; Müller, Tobias ; Favelli, Lorenzo ; Blombach, Bastian ; Takors, Ralf: Micro-aerobic production of isobutanol with engineered Pseudomonas putida. In: Engineering in Life Science (2021)

  6. 2020

    1. 120.
      Kuschel, Maike ; Takors, Ralf: Simulated oxygen and glucose gradients as a prerequisite for predicting industrial scale performance a priori. In: Biotechnology and Bioengineering (2020)
    2. 119.
      Ziegler, Martin ; Zieringer, Julia ; Takors, Ralf: Transcriptional Profiling of the Stringent Response Mutant Strain E. coli SR Reveals Enhanced Robustness to Large-Scale Conditions. In: microbial biotechnology (2020)
    3. 118.
      Verhagen, Natascha ; Wijaya, Andy Wiranata ; Teleki, Attila ; Fadhlullah, Muhammad ; Unsöld, Andreas ; Schilling, Martin ; Heinrich, Christoph ; Takors, Ralf: Comparison of l-tyrosine containing dipeptides reveals maximum ATP availability for l-prolyl-l-tyrosine in CHO cells. In: Engineering in Life Science (2020)
    4. 117.
      Zieringer, Julia ; Wild, Moritz ; Takors, Ralf: Data‐driven in silico prediction of regulation heterogeneity and ATP demands of Escherichia coli in large‐scale bioreactors. In: Biotechnol. Bioeng. Bd. 118 (2020), S. 265–278
    5. 116.
      Verhagen, Natascha ; Zieringer, Julia ; Takors, Ralf: Methylthioadenosine (MTA) boosts cell-specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression. In: FEBS Open Bio Bd. 10 (2020), S. 2791–2804
    6. 115.
      Müller, F. ; Rapp, J. ; Hacker, A.-L. ; Feith, A. ; Takors, R. ; Blombach, B.: CO2/HCO3- accelerates iron reduction through phenolic compounds. In: mbio (2020)
    7. 114.
      Verhagen, Natascha ; Teleki, Attila ; Heinrich, Christoph ; Schilling, Martin ; Unsoeld, Andreas ; Takors, Ralf: S-adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese hamster ovary cells. In: Biotechnol. Bioeng. (2020)
    8. 113.
      Hermann, Maria ; Teleki, Attila ; Weitz, Sandra ; Niess, Alexander ; Freund, Andreas ; Bengelsdorf, Frank R ; Takors, Ralf: Electron availability in CO2, CO and H2 mixtures constrains flux distribution, energy management and product formation in Clostridium ljungdahlii. In: Microbial Biotechnology (2020)
    9. 112.
      Feith, André ; Schwentner, Andreas ; Teleki, Attila ; Favilli, Lorenzo ; Blombach, Bastian ; Takors, Ralf: Streamlining the Analysis of Dynamic 13C-Labeling Patterns for the Metabolic Engineering of Corynebacterium glutamicum as l-Histidine Production Host. In: Metabolites Bd. 10 (2020)
    10. 111.
      Patil, Vikas ; Santos, Christine N.S. ; Ajikumar, Parayil K. ; Sarria, Stephen ; Takors, Ralf: Balancing glucose and oxygen uptake rates to enable high amorpha‐4,11‐diene production in Escherichia coli via the methylerythritol phosphate pathway. In: Biotechnol. Bioeng. (2020)
    11. 110.
      Müller, Jan ; Siemann-Herzberg, Martin ; Takors, Ralf: Modeling Cell-Free Protein Synthesis Systems—Approaches and Applications. In: Frontiers in Bioengineering and Biotechnology (2020)
    12. 109.
      Graf, Michaela ; Haas, Thorsten ; Teleki, Attila ; Feith, André ; Cerff, Martin ; Wiechert, Wolfgang ; Noeh, Katharina ; Busche, Tobias ; u. a.: Revisiting the Growth Modulon of Corynebacterium glutamicum Under Glucose Limited Chemostat Conditions. In: Frontiers in Bioengineering and Biotechnology (2020)
    13. 108.
      Sarkizi Shams Hajian, Christopher ; Haringa, Cees ; Noorman, Henk ; Takors, Ralf: Predicting By-Product Gradients of Baker’s Yeast Production at Industrial Scale: A Practical Simulation Approach. In: Processes Bd. 8 (2020)
    14. 107.
      Siebler, F. ; Lapin, A. ; Takors, R.: Synergistically Applying 1D modeling and CFD for Designing Industrial Scale Bubble Column Syngas Bioreactors. In: Engineering in Life Science (2020)
    15. 106.
      Ankenbauer, A. ; Schäfer, R. ; Viegas, S.C. ; Pobre, V. ; Voß, B. ; Arraiano, C. M. ; Takors, R.: Pseudomonas putida KT2440 is naturally endowed to withstand industrial-scale stress conditions. In: micobial biotechnology (2020), S. 1–17

  7. 2019

    1. 105.
      Graf, M. ; Haas, T. ; Müller, F. ; Buchmann, A. ; Harm-Betbenbetova, J. ; Freund, A. ; Nieß, A. ; Persicke, M. ; u. a.: Continuous Adaptive Evolution of a Fast-Growing Corynebacterium glutamicum Strain Independent of Protocatechuate. In: Frontiers in Microbiology (2019)
    2. 104.
      Nieß, Alexander ; Siemann-Herzberg, Martin ; Takors, Ralf: Protein production in Escherichia coli is guided by the trade‑off between intracellular substrate availability and energy cost. In: Microbial Cell Factories Bd. 18 (2019)
    3. 103.
      Grenz, S. ; Baumann, P.T. ; Rückert, C. ; Nebel, B.A. ; Siebert, D. ; Schwentner, A. ; Eikmanns, B.J. ; Hauer, B. ; u. a.: Exploting Hydrogenophage pseudoflava for aerobic syngas-based production of chemicals. In: Metabolic Engineering Bd. 55 (2019), S. 220–230
    4. 102.
      Nitschel, R. ; Ankenbauer, A. ; Welsch, I. ; Wirth, N.T. ; Massner, C. ; Ahmad, N. ; McColm, S. ; Borges, F. ; u. a.: Engineering Pseudomonas putida KT2440 for the production of isobutanol. In: Engineering in Life Science Bd. 20 (2019), S. 148–159
    5. 101.
      Straathof, Adrie JJ ; Wahl, S Aljoscha ; Benjamin, Kirsten R ; Takors, Ralf ; Wierckx, Nick ; Noorman, Henk J: Grand research challenges for sustainable industrial biotechnology. In: Trends in biotechnology Bd. 37, Elsevier Current Trends (2019), S. 1042–1050
    6. 100.
      Junghans, L ; Teleki, A ; Wijaya, AW ; Becker, M ; Schweikert, M ; Takors, R: From nutrional wealth to autophagy: In vivo metabolic dynamics in the cytosol, mitochondrion and shuttles of IgG producing CHO cells. In: Metabolic Engineering Bd. 54 (2019), S. 145–159
    7. 99.
      Becker, M ; Junghans, L ; Teleki, A ; Bechmann, J ; Takors, R: The less the better: How suppressed base addition boosts production of monoclonal antibodies with Chinese Hamster Ovary Cells. In: Frontiers in Bioengineering and Biotechnlogy Bd. 7 (2019)
    8. 98.
      Schwentner, A ; Feith, A ; Münch, E ; Stiefelmaier, J ; Lauer, I ; Favilli, L ; Massner, C ; Öhrlein, J ; u. a.: Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum. In: Biotechnology for Biofuels Bd. 12 (2019)
    9. 97.
      Becker, Max ; Junghans, Lisa ; Teleki, Attila ; Bechmann, Jan ; Takors, Ralf: Perfusion cultures equire optimum respiratory ATP supply to maximize cell‐specific and volumetric productivities. In: Biotechnol. Bioeng. (2019), S. 1–10
    10. 96.
      Haas, T. ; Graf, M. ; Nieß, A. ; Busche, T. ; Kalinowski, J. ; Blombach, B. ; Takors, T.: Identifying the Growth Modulon of Corynebacterium glutamicum. In: Frontiers in Microbiology Bd. 10 (2019)
    11. 95.
      Takors, R.: Biochemical engineering provides mindset, tools and solutions for the driving questions of a sustainable future. In: Engineering in Life Science (2019)
    12. 94.
      Pobre, V. ; Graça-Lopes, G. ; Saramago, M. ; Ankenbauer, A. ; Takors, T. ; Arraiano, C.M. ; Viegas, S.C.: Prediction of novel non-coding RNAs relevant for the growth of Pseudomonas putida in a bioreactor. In: Microbiology (2019)
    13. 93.
      Ziegler, M. ; Takors, R.: Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis. In: Minimal Cells: Design, Construction, Biotechnological Applications. In: Lara, A. R. ; Gosset Lagarda, G. (Hrsg.) ; Lara, A. R. ; Gosset Lagarda, G. (Hrsg.): , 2019 — ISBN 978-3-030-31896-3
    14. 92.
      Siebler, F ; Lapin, A ; Hermann, M ; Takors, R: The impact of CO gradients on C. ljungdahlii in a 125 m³ bubble column: Mass transfer, circulation time and lifeline analysis. In: Chemical Engineering Science Bd. 207 (2019), S. 410–423
    15. 91.
      Feith, A ; Teleki, A ; Graf, M ; Favilli, L ; Takors, R: HILIC-Enabled 13C Metabolomics Strategies: Comparing Quantitative Precision and Spectral Accuracy of QToF High - and QQQ Low-Resolution Mass Spectrometry. In: Metabolites (2019)

  8. 2018

    1. 90.
      Graf, Michaela ; Zieringer, Julia ; Haas, Thorsten ; Nieß, Alexander ; Blombach, Bastian ; Takors, Ralf: Physiological Response of Corynebacterium glutamicum to Increasingly Nutrient-Rich Growth Conditions. In: Frontiers in Microbiology Bd. 9, Frontiers Media SA (2018)
    2. 89.
      Lange, Julian ; Münch, Eugenia ; Müller, Jan ; Busche, Tobias ; Kalinowski, Jörn ; Takors, Ralf ; Blombach, Bastian: Deciphering the Adaptation of Corynebacterium glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis. In: Genes Bd. 9 (2018), S. 297
    3. 88.
      Zieringer, Julia ; Takors, Ralf: In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models. In: Computational and Structural Biotechnology Journal Bd. 16 (2018), S. 246–256
    4. 87.
      Takors, Ralf ; Kopf, Michael ; Mampel, Joerg ; Bluemke, Wilfried ; Blombach, Bastian ; Eikmanns, Bernhard ; Bengelsdorf, Frank R ; Weuster-Botz, Dirk ; u. a.: Using gas mixtures of CO, CO2 and H2 as microbial substrates: the do’s and don’ts of successful technology transfer from laboratory to production scale. In: Microbial Biotechnology Bd. 11 (2018), S. 606–625
    5. 86.
      Lange, Julian ; Müller, Felix ; Takors, Ralf ; Blombach, Bastian: Harnessing novel chromosomal integration loci to utilize an organosolv-derived hemicellulose fraction for isobutanol production with engineered Corynebacterium glutamicum. In: Microbial Biotechnology Bd. 11 (2018), S. 257–263
    6. 85.
      Barbosa, Sara ; Niebel, Bastian ; Wolf, Sebastian ; Mauch, Klaus ; Takors, Ralf: A guide to gene regulatory network interference for obtaining predictive solutions: Underlying assumptions and fundamental biological and data constraints. In: BioSystems Bd. 174 (2018), S. 37–48
    7. 84.
      Schwentner, Andreas ; Feith, Andre ; Münch, Eugenia ; Busche, Thomas ; Rückert, Christian ; Kalinowskis, Jörg ; Takors, Ralf ; Blombach, Bastian: Metabolic engineering to guide evolution - Creating a novel mode for L-valine production with Corynebacterium glutamicum. In: Metabolic Engineering Bd. 47 (2018), S. 31–41

  9. 2017

    1. 83.
      Loeffler, Michael ; Simen, Joana Danica ; Mueller, Jan ; Jaeger, Gunter ; Laghrami, Salaheddine ; Schaeferhoff, Karin ; Freund, Andreas ; Takors, Ralf ; u. a.: Switching between nitrogen and glucose limitation: Unraveling transcriptional dynamics in Escherichia coli. In: JOURNAL OF BIOTECHNOLOGY Bd. 258. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. 2–12
    2. 82.
      Niess, Alexander ; Failmezger, Jurek ; Kuschel, Maike ; Siemann-Herzberg, Martin ; Takors, Ralf: Experimentally Validated Model Enables Debottlenecking of in Vitro Protein Synthesis and Identifies a Control Shift under in Vivo Conditions. In: ACS SYNTHETIC BIOLOGY Bd. 6. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, AMER CHEMICAL SOC, S. 1913–1921
    3. 81.
      Lange, Julian ; Mueller, Felix ; Bernecker, Kerstin ; Dahmen, Nicolaus ; Takors, Ralf ; Blombach, Bastian: Valorization of pyrolysis water: a biorefinery side stream, for 1,2-propanediol production with engineered Corynebacterium glutamicum. In: BIOTECHNOLOGY FOR BIOFUELS Bd. 10. 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND, BIOMED CENTRAL LTD
    4. 80.
      Teleki, A. ; Rahnert, M. ; Bungart, O. ; Gann, B. ; Ochrombel, I. ; Takors, R.: Robust identification of metabolic control for microbial L-methionine production following an easy-to-use puristic approach. In: METABOLIC ENGINEERING Bd. 41. 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, ACADEMIC PRESS INC ELSEVIER SCIENCE, S. 159–172
    5. 79.
      Niess, Alexander ; Loeffler, Michael ; Simen, Joana D. ; Takors, Ralf: Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E-coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model. In: FRONTIERS IN MICROBIOLOGY Bd. 8. PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND, FRONTIERS MEDIA SA
    6. 78.
      Simen, Joana Danica ; Loeffler, Michael ; Jaeger, Guenter ; Schaeferhoff, Karin ; Freund, Andreas ; Matthes, Jakob ; Mueller, Jan ; Takors, Ralf ; u. a.: Transcriptional response of Escherichia coli to ammonia and glucose fluctuations. In: MICROBIAL BIOTECHNOLOGY Bd. 10. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY, S. 858–872
    7. 77.
      Eigenstetter, Gerhard ; Takors, Ralf: Dynamic modeling reveals a three-step response of Saccharomyces cerevisiae to high CO2 levels accompanied by increasing ATP demands. In: FEMS YEAST RESEARCH Bd. 17. GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND, OXFORD UNIV PRESS
    8. 76.
      Lange, Julian ; Takors, Ralf ; Blombach, Bastian: Zero-growth bioprocesses: A challenge for microbial production strains and bioprocess engineering. In: ENGINEERING IN LIFE SCIENCES Bd. 17. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY-BLACKWELL, S. 27–35
    9. 75.
      Wolf, Sebastian ; Barbosa, Sara ; Bücher, Joachim ; Takors, Ralf: Automatic network generation describes differential gene data in user friendly and expeditiously analyzable network views. In: Genetics, B. ; Genomics (Hrsg.) Bd. 2 (2017), S. 1–14
    10. 74.
      Kuschel, Maike ; Siebler, Flora ; Takors, Ralf: Lagrangian trajectories to predict the formation of population heterogeneity in large-scale bioreactors. In: Bioengineering Bd. 4, MDPI (2017), S. 27
    11. 73.
      Michalowski, Annette ; Siemann-Herzberg, Martin ; Takors, Ralf: Escherichia coli HGT: engineered for high glucose throughput even under slowly growing or resting conditions. In: Metabolic engineering Bd. 40, Academic Press (2017), S. 93–103
    12. 72.
      Delvigne, Frank ; Takors, Ralf ; Mudde, Rob ; van Gulik, Walter ; Noorman, Henk: Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond. In: Microbial biotechnology Bd. 10 (2017), S. 1267–1274
    13. 71.
      Hellmers, F ; Takors, Ralf ; Thum, O: Robust Enzyme Immobilizates for Industrial Isomalt Production. In: Molecular Catalysis Bd. 445 (2017), S. 293–298
    14. 70.
      Hoffart, Eugenia ; Grenz, Sebastian ; Lange, Julian ; Nitschel, Robert ; Müller, Felix ; Schwentner, Andreas ; Feith, André ; Lenfers-Lücker, Mira ; u. a.: High substrate uptake rates empower Vibrio natriegens as production host for industrial biotechnology. In: Applied and environmental microbiology Bd. 83, American Society for Microbiology 1752 N St., NW, Washington, DC (2017), S. e01614––17

  10. 2016

    1. 69.
      Takors, Ralf ; de Lorenzo, Victor: Editorial overview: Microbial systems biology: systems biology prepares the ground for successful synthetic biology. In: CURRENT OPINION IN MICROBIOLOGY Bd. 33. 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND, CURRENT BIOLOGY LTD, S. VIII–X
    2. 68.
      Wutz, Johannes ; Lapin, Alexey ; Siebler, Flora ; Schaefer, Jan Erik ; Wucherpfennig, Thomas ; Berger, Martina ; Takors, Ralf: Predictability of k(L)a in stirred tank reactors under multiple operating conditions using an Euler-Lagrange approach. In: ENGINEERING IN LIFE SCIENCES Bd. 16. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY, S. 633–642
    3. 67.
      Takors, Ralf: Editorial: How can we ensure the successful transfer from lab- to large-scale production? In: ENGINEERING IN LIFE SCIENCES Bd. 16. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY, S. 587
    4. 66.
      Loeffler, Michael ; Simen, Joana Danica ; Jaeger, Guenter ; Schaeferhoff, Karin ; Freund, Andreas ; Takors, Ralf: Engineering E-coli for large-scale production - Strategies considering ATP expenses and transcriptional responses. In: METABOLIC ENGINEERING Bd. 38. 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, ACADEMIC PRESS INC ELSEVIER SCIENCE, S. 73–85
    5. 65.
      Junghans, Lisa ; Teleki, Attila ; Becker, Max ; Takors, Ralf: LC-MS-based compartment-specific metabolome analysis in CHO. In: NEW BIOTECHNOLOGY Bd. 33. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. S33–S34
    6. 64.
      Sanchez-Kopper, Andres ; Becker, Max ; Pfizenmaier, Jennifer ; Kessler, Christian ; Karau, Andreas ; Takors, Ralf: Tracking dipeptides at work-uptake and intracellular fate in CHO culture. In: AMB EXPRESS Bd. 6. 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND, BIOMED CENTRAL LTD
    7. 63.
      Lieder, Sarah ; Jahn, Michael ; Koepff, Joachim ; Mueller, Susann ; Takors, Ralf: Environmental stress speeds up DNA replication in Pseudomonas putida in chemostat cultivations. In: BIOTECHNOLOGY JOURNAL Bd. 11. POSTFACH 101161, 69451 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 155–163
    8. 62.
      Pfizenmaier, Jennifer ; Junghans, Lisa ; Teleki, Attila ; Takors, Ralf: Hyperosmotic stimulus study discloses benefits in ATP supply and reveals miRNA/mRNA targets to improve recombinant protein production of CHO cells. In: BIOTECHNOLOGY JOURNAL Bd. 11. POSTFACH 101161, 69451 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 1037–1047
    9. 61.
      Löffler, Michael ; Simen, Joana Danica ; Jäger, Günter ; Schäferhoff, Karin ; Freund, Andreas ; Takors, Ralf: Engineering E. coli for large-scale production--strategies considering ATP expenses and transcriptional responses. In: Metabolic engineering Bd. 38, Academic Press (2016), S. 73–85
    10. 60.
      Sudarsan, Suresh ; Blank, Lars M ; Dietrich, Alexander ; Vielhauer, Oliver ; Takors, Ralf ; Schmid, Andreas ; Reuss, Matthias: Dynamics of benzoate metabolism in Pseudomonas putida KT2440. In: Metabolic Engineering Communications Bd. 3, Elsevier (2016), S. 97–110

  11. 2015

    1. 59.
      Pfizenmaier, Jennifer ; Matuszczyk, Jens-Christoph ; Takors, Ralf: Changes in intracellular ATP-content of CHO cells as response to hyperosmolality. In: BIOTECHNOLOGY PROGRESS Bd. 31. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY-BLACKWELL, S. 1212–1216. — 14th Conference on Cell Culture Engineering (CCE), Quebec, CANADA, MAY 04-09, 2014
    2. 58.
      Vallon, Tobias ; Simon, Oliver ; Rendgen-Heugle, Beate ; Frana, Sabine ; Mueckschel, Bjoern ; Broicher, Alexander ; Siemann-Herzberg, Martin ; Pfannenstiel, Jens ; u. a.: Applying systems biology tools to study n-butanol degradation in Pseudomonas putida KT2440. In: ENGINEERING IN LIFE SCIENCES Bd. 15. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY-BLACKWELL, S. 760–771
    3. 57.
      Rimbon, Jeremy ; Sanchez-Kopper, Andres ; Wahl, Andreas ; Takors, Ralf: Monitoring intracellular protein degradation in antibody-producing Chinese hamster ovary cells. In: ENGINEERING IN LIFE SCIENCES Bd. 15. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY-BLACKWELL, S. 499–508
    4. 56.
      Teleki, Attila ; Sanchez-Kopper, Andres ; Takors, Ralf: Alkaline conditions in hydrophilic interaction liquid chromatography for intracellular metabolite quantification using tandem mass spectrometry. In: ANALYTICAL BIOCHEMISTRY Bd. 475. 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, ACADEMIC PRESS INC ELSEVIER SCIENCE, S. 4–13
    5. 55.
      Blombach, Bastian ; Takors, Ralf: CO2--intrinsic product, essential substrate, and regulatory trigger of microbial and mammalian production processes. In: Frontiers in bioengineering and biotechnology Bd. 3, Frontiers Media SA (2015), S. 108
    6. 54.
      Lieder, Sarah ; Nikel, Pablo I ; de Lorenzo, V\‘ıctor ; Takors, Ralf: Genome reduction boosts heterologous gene expression in Pseudomonas putida. In: Microbial cell factories Bd. 14, BioMed Central (2015), S. 1–14
    7. 53.
      Matuszczyk, Jens-Christoph ; Teleki, Attila ; Pfizenmaier, Jennifer ; Takors, Ralf: Compartment-specific metabolomics for CHO reveals that ATP pools in mitochondria are much lower than in cytosol. In: Biotechnology Journal Bd. 10, WILEY-VCH Verlag Weinheim (2015), S. 1639–1650

  12. 2014

    1. 52.
      Buchholz, Jens ; Graf, Michaela ; Blombach, Bastian ; Takors, Ralf: Improving the carbon balance of fermentations by total carbon analyses. In: BIOCHEMICAL ENGINEERING JOURNAL Bd. 90. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. 162–169
    2. 51.
      Schuhmacher, Tom ; Loeffler, Michael ; Hurler, Thilo ; Takors, Ralf: Phosphate limited fed-batch processes: Impact on carbon usage and energy metabolism in Escherichia coli. In: JOURNAL OF BIOTECHNOLOGY Bd. 190. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. 96–104
    3. 50.
      Gelves, Ricardo ; Dietrich, A. ; Takors, Ralf: Modeling of gas-liquid mass transfer in a stirred tank bioreactor agitated by a Rushton turbine or a new pitched blade impeller. In: BIOPROCESS AND BIOSYSTEMS ENGINEERING Bd. 37. 233 SPRING ST, NEW YORK, NY 10013 USA, SPRINGER, S. 365–375
    4. 49.
      Lieder, Sarah ; Jahn, Michael ; Seifert, Jana ; von Bergen, Martin ; Mueller, Susann ; Takors, Ralf: Subpopulation-proteomics reveal growth rate, but not cell cycling, as a major impact on protein composition in Pseudomonas putida KT2440. In: AMB EXPRESS Bd. 4. 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND, BIOMED CENTRAL LTD
    5. 48.
      Buchholz, Jens ; Graf, Michaela ; Freund, Andreas ; Busche, Tobias ; Kalinowski, Jörn ; Blombach, Bastian ; Takors, Ralf: CO 2/HCO 3- perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum. In: Applied microbiology and biotechnology Bd. 98, Springer Berlin Heidelberg (2014), S. 8563–8572

  13. 2013

    1. 47.
      Vallon, Tobias ; Glemser, Matthias ; Malca, Sumire Honda ; Scheps, Daniel ; Schmid, Joachim ; Siemann-Herzberg, Martin ; Hauer, Bernhard ; Takors, Ralf: Production of 1-Octanol from n-Octane by Pseudomonas putida KT2440. In: CHEMIE INGENIEUR TECHNIK Bd. 85. BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 841–848
    2. 46.
      Soellner, S. ; Rahnert, M. ; Siemann-Herzberg, M. ; Takors, R. ; Altenbuchner, J.: Evolution of pyruvate kinase-deficient Escherichia coli mutants enables glycerol-based cell growth and succinate production. In: JOURNAL OF APPLIED MICROBIOLOGY Bd. 115. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY-BLACKWELL, S. 1368–1378
    3. 45.
      Blombach, Bastian ; Buchholz, Jens ; Busche, Tobias ; Kalinowski, Jörn ; Takors, Ralf: Impact of different CO2/HCO3- levels on metabolism and regulation in Corynebacterium glutamicum. In: Journal of biotechnology Bd. 168, Elsevier (2013), S. 331–340
    4. 44.
      Buchholz, Jens ; Schwentner, Andreas ; Brunnenkan, Britta ; Gabris, Christina ; Grimm, Simon ; Gerstmeir, Robert ; Takors, Ralf ; Eikmanns, Bernhard J ; u. a.: Platform engineering of Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improved production of L-lysine, L-valine, and 2-ketoisovalerate. In: Applied and environmental microbiology Bd. 79, American Society for Microbiology (2013), S. 5566–5575

  14. 2012

    1. 43.
      Takors, R: Scale-up of microbial processes: impacts, tools and open questions. In: Journal of biotechnology Bd. 160, Elsevier (2012), S. 3–9

  15. 2011

    1. 42.
      Vielhauer, Oliver ; Zakhartsev, Maksim ; Horn, Thomas ; Takors, Ralf ; Reuss, Matthias: Simplified absolute metabolite quantification by gas chromatography-isotope dilution mass spectrometry on the basis of commercially available source material. In: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES Bd. 879. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. 3859–3870
    2. 41.
      Bongaerts, Johannes ; Esser, Simon ; Lorbach, Volker ; Al-Momani, Loay ; Mueller, Michael A. ; Franke, Dirk ; Grondal, Christoph ; Kurutsch, Anja ; u. a.: Diversity-Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Bd. 50. BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 7781–7786

  16. 2009

    1. 40.
      Magnus, Jorgen Barsett ; Oldiges, Marco ; Takors, Ralf: The Identification of Enzyme Targets for the Optimization of a Valine Producing Corynebacterium glutamicum Strain Using a Kinetic Model. In: BIOTECHNOLOGY PROGRESS Bd. 25. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, AMER CHEMICAL SOC, S. 754–762

  17. 2007

    1. 39.
      Takors, R. ; Bathe, B. ; Rieping, M. ; Hans, S. ; Kelle, R. ; Huthmacher, K.: Systems biology for industrial strains and fermentation processes - Example: Amino acids. In: JOURNAL OF BIOTECHNOLOGY Bd. 129. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. 181–190. — International Workshop on Molecular Systems Biology, Bielefeld Univ, Bielefeld, GERMANY, JUN, 2006
    2. 38.
      Noeh, Katharina ; Groenke, Karsten ; Luo, Bing ; Takors, Ralf ; Oldiges, Marco ; Wiechert, Wolfgang: Metabolic flux analysis at ultra short time scale: Isotopically non-stationary C-13 labeling experiments. In: JOURNAL OF BIOTECHNOLOGY Bd. 129. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. 249–267. — International Workshop on Molecular Systems Biology, Bielefeld Univ, Bielefeld, GERMANY, JUN, 2006
    3. 37.
      Luo, Bing ; Groenke, Karsten ; Takors, Ralf ; Wandrey, Christian ; Oldiges, Marco: Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography--mass spectrometry. In: Journal of chromatography A Bd. 1147, Elsevier (2007), S. 153–164
    4. 36.
      Nöh, Katharina ; Grönke, Karsten ; Luo, Bing ; Takors, Ralf ; Oldiges, Marco ; Wiechert, Wolfgang: Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments. In: Journal of biotechnology Bd. 129, Elsevier (2007), S. 249–267

  18. 2006

    1. 35.
      Wahl, SA ; Takors, R ; Wiechert, W: Interpretation of metabolic flux maps by limitation potentials and constrained limitation sensitivities. In: BIOTECHNOLOGY AND BIOENGINEERING Bd. 94. 111 RIVER ST, HOBOKEN, NJ 07030 USA, JOHN WILEY & SONS INC, S. 263–272
    2. 34.
      Magnus, Jørgen Barsett ; Hollwedel, Daniel ; Oldiges, Marco ; Takors, Ralf: Monitoring and modeling of the reaction dynamics in the valine/leucine synthesis pathway in Corynebacterium glutamicum. In: Biotechnology Progress Bd. 22, American Chemical Society USA (2006), S. 1071–1083

  19. 2005

    1. 33.
      Ternbach, MB ; Bollman, C ; Wandrey, C ; Takors, R: Application of model discriminating experimental design for modeling and development of a fermentative fed-batch L-valine production process. In: BIOTECHNOLOGY AND BIOENGINEERING Bd. 91. 111 RIVER ST, HOBOKEN, NJ 07030 USA, JOHN WILEY & SONS INC, S. 356–368
    2. 32.
      Oldiges, M ; Takors, R: Applying metabolic profiling techniques for stimulus-response experiments: Chances and pitfalls. In: TECHNOLOGY TRANSFER IN BIOTECHNOLOGY: FROM LAB TO INDUSTRY TO PRODUCTION, Advances in Biochemical Engineering-Biotechnology. Bd. 92. HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY : SPRINGER-VERLAG BERLIN — ISBN 3-540-22412-2, S. 173–196
    3. 31.
      Haunschild, Marc Daniel ; Freisleben, Bernd ; Takors, Ralf ; Wiechert, Wolfgang: Investigating the dynamic behavior of biochemical networks using model families. In: Bioinformatics Bd. 21, Oxford University Press (2005), S. 1617–1625

  20. 2004

    1. 30.
      Oldiges, M ; Kunze, M ; Degenring, D ; Sprenger, GA ; Takors, R: Stimulation, monitoring, and analysis of pathway dynamics by metabolic profiling in the aromatic amino acid pathway. In: BIOTECHNOLOGY PROGRESS Bd. 20. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, WILEY, S. 1623–1633
    2. 29.
      Zelic, B ; Gostovic, S ; Vuorilehto, K ; Vasic-Racki, B ; Takors, R: Process strategies to enhance pyruvate production with recombinant Escherichia coli: from repetitive fed-batch to in situ product recovery with fully integrated electrodialysis. In: BIOTECHNOLOGY AND BIOENGINEERING Bd. 85. 111 RIVER ST, HOBOKEN, NJ 07030 USA, JOHN WILEY & SONS INC, S. 638–646
    3. 28.
      Ruffer, N ; Heidersdorf, U ; Kretzers, I ; Sprenger, GA ; Raeven, L ; Takors, R: Fully integrated L-phenylalanine separation and concentration using reactive-extraction with liquid-liquid centrifuges in a fed-batch process with E-coli. In: BIOPROCESS AND BIOSYSTEMS ENGINEERING Bd. 26. 233 SPRING ST, NEW YORK, NY 10013 USA, SPRINGER, S. 239–248
    4. 27.
      Takors, R: Model-based analysis and optimization of an ISPR approach using reactive extraction for pilot-scale L-phenylalanine production. In: BIOTECHNOLOGY PROGRESS Bd. 20. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, AMER CHEMICAL SOC, S. 57–64
    5. 26.
      Takors, R: Complete cell ISPR process development: Chances and risks. In: CHEMIE INGENIEUR TECHNIK Bd. 76. PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 1857–1864. — BioPerspectives 2004 Conference, Wiesbaden, GERMANY, MAY 04-06, 2004
    6. 25.
      Takors, R: Whole cell ISPR process development: Chances and pitfalls. In: CHEMIE INGENIEUR TECHNIK Bd. 76. PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 1807–1814. — BioPerspectives 2004 Conference, Wiesbaden, GERMANY, MAY 04-06, 2004
    7. 24.
      Wahl, Aljoscha ; Massaoudi, Mohamed El ; Schipper, Dick ; Wiechert, Wolfgang ; Takors, Ralf: Serial 13C-based flux analysis of an L-phenylalanine-producing E. coli strain using the sensor reactor. In: Biotechnology progress Bd. 20, American Chemical Society USA (2004), S. 706–714
    8. 23.
      Drysch, A ; El Massaoudi, M ; Wiechert, W ; De Graaf, AA ; Takors, R: Serial flux mapping of Corynebacterium glutamicum during fed-batch L-lysine production using the sensor reactor approach. In: Biotechnology and bioengineering Bd. 85, Wiley Online Library (2004), S. 497–505
    9. 22.
      Degenring, Daniela ; Froemel, C ; Dikta, G ; Takors, R: Sensitivity analysis for the reduction of complex metabolism models. In: Journal of Process Control Bd. 14, Elsevier (2004), S. 729–745
    10. 21.
      Zelić, Bruno ; Vasić-Racki, Đurđa ; Wandrey, Christian ; Takors, Ralf: Modeling of the pyruvate production with Escherichia coli in a fed-batch bioreactor. In: Bioprocess and Biosystems Engineering Bd. 26, Springer-Verlag (2004), S. 249–258

  21. 2003

    1. 20.
      Franke, D ; Lorbach, V ; Esser, S ; Dose, C ; Sprenger, GA ; Halfar, M ; Thommes, J ; Muller, R ; u. a.: (S,S)-2,3-dihydroxy-2,3-dihydrobenzoic acid: Microbial access with engineered cells of Escherichia coli and application as starting material in natural-product synthesis. In: CHEMISTRY-A EUROPEAN JOURNAL Bd. 9. PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 4188–4196
    2. 19.
      Drysch, A ; El Massaoudi, M ; Mack, C ; Takors, R ; de Graaf, AA ; Sahm, H: Production process monitoring by serial mapping of microbial carbon flux distributions using a novel Sensor Reactor approach: II - C-13-labeling-based metabolic flux analysis and L-lysine production. In: METABOLIC ENGINEERING Bd. 5. 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, ACADEMIC PRESS INC ELSEVIER SCIENCE, S. 96–107
    3. 18.
      El Massaoudi, M ; Spelthahn, J ; Drysch, A ; de Graaf, A ; Takors, R: Production process monitoring by serial mapping of microbial carbon flux distributions using a novel sensor reactor approach: I�sensor reactor system. In: Metabolic Engineering Bd. 5, Academic Press (2003), S. 86–95
    4. 17.
      Zelić, Bruno ; Gerharz, Tanja ; Bott, Michael ; Vasić-Racki, Đurđa ; Wandrey, Christian ; Takors, Ralf: Fed-batch process for pyruvate production by recombinant Escherichia coli YYC202 strain. In: Engineering in life sciences Bd. 3, Wiley Online Library (2003), S. 299–305

  22. 2002

    1. 16.
      Schmitz, M ; Hirsch, E ; Bongaerts, J ; Takors, R: Pulse experiments as a prerequisite for the quantification of in vivo enzyme kinetics in aromatic amino acid pathway of Escherichia coli. In: BIOTECHNOLOGY PROGRESS Bd. 18. THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND, JOHN WILEY & SONS LTD, S. 935–941
    2. 15.
      Maass, D ; Gerigk, MR ; Kreutzer, A ; Weuster-Botz, D ; Wubbolts, M ; Takors, R: Integrated L-phenylalanine separation in an E-coli fed-batch process: from laboratory to pilot scale. In: BIOPROCESS AND BIOSYSTEMS ENGINEERING Bd. 25. 233 SPRING ST, NEW YORK, NY 10013 USA, SPRINGER, S. 85–96
    3. 14.
      Gerigk, M ; Bujnicki, R ; Ganpo-Nkwenkwa, E ; Bongaerts, J ; Sprenger, G ; Takors, R: Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains. In: BIOTECHNOLOGY AND BIOENGINEERING Bd. 80. 111 RIVER ST, HOBOKEN, NJ 07030 USA, JOHN WILEY & SONS INC, S. 746–754
    4. 13.
      Gerigk, Maass ; Maass, D ; Kreutzer, A ; Sprenger, G ; Bongaerts, Johannes ; Wubbolts, Marcel ; Takors, Ralf: Enhanced pilot-scale fed-batch L-phenylalanine production with recombinant Escherichia coli by fully integrated reactive extraction. In: Bioprocess and biosystems engineering Bd. 25, Springer-Verlag (2002), S. 43–52
    5. 12.
      Hurlebaus, J. ; Buchholz, A. ; Alt, W. ; Wiechert, W. ; Takors, R.: MMT – A Pathway Modeling Tool for Data From Rapid Sampling Experiments. In: In Silico Biology Bd. 2 (2002), S. 467–484
    6. 11.
      Curvers, Simon ; Linnemann, Jörg ; Klauser, Thomas ; Wandrey, Christian ; Takors, Ralf: Recombinant protein production with Pichia pastoris in continuous fermentation--kinetic analysis of growth and product formation. In: Engineering in Life Sciences Bd. 2, WILEY-VCH Verlag Weinheim (2002), S. 229–235
    7. 10.
      Buchholz, Arne ; Hurlebaus, Jochen ; Wandrey, Christian ; Takors, Ralf: Metabolomics: quantification of intracellular metabolite dynamics. In: Biomolecular engineering Bd. 19, Elsevier (2002), S. 5–15

  23. 2001

    1. 9.
      Takors, R ; Gerigk, M ; Paschold, H ; Wandrey, C: Principal-component analysis for microbial L-phenylalanine production. In: BIOPROCESS AND BIOSYSTEMS ENGINEERING Bd. 24. 175 FIFTH AVE, NEW YORK, NY 10010 USA, SPRINGER-VERLAG, S. 93–99
    2. 8.
      Curvers, S ; Linneman, J ; Klauser, T ; Wandrey, C ; Takors, R: Recombinant protein production with Pichia pastoris in continuous fermentation - Kinetic analysis of growth and product formation. In: CHEMIE INGENIEUR TECHNIK Bd. 73. PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY, WILEY-V C H VERLAG GMBH, S. 1615–1621
    3. 7.
      Thömmes, J. ; Halfar, M. ; Gieren, H. ; Curvers, S. ; Takors, R. ; Brunschier, R. ; Kula, M.R.: Human chymotrypsinogen B production with Pichia pastoris by integrated fermentation and downstream processing Part II: Protein recovery. In: Biotechnol. Prog Bd. 17 (2001), S. 503–512
    4. 6.
      Buchholz, Arne ; Takors, Ralf ; Wandrey, Christian: Quantification of intracellular metabolites in Escherichia coli K12 using liquid chromatographic-electrospray ionization tandem mass spectrometric techniques. In: Analytical biochemistry Bd. 295, Elsevier (2001), S. 129–137
    5. 5.
      Curvers, S. ; Brixius, P. ; Klauser, T. ; Weuster-Botz, D. ; Takors, R. ; Wandrey, C.: Human chymotrypsinogen B production with Pichia pastoris by integrated fermentation and downstream processing Part I: Fermentation processing. In: Biotechnol. Prog Bd. 17 (2001), S. 495–502

  24. 2000

    1. 4.
      Schmitz, G ; Franke, D ; Stevens, S ; Takors, R ; Weuster-Botz, D ; Wandrey, C: Regioselective oxidation of terfenadine with Cunninghamella blakesleeana. In: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC Bd. 10. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, ELSEVIER SCIENCE BV, S. 313–324
    2. 3.
      Dilsen, S. ; Paul, W. ; Sandgathe, A. ; Tippe, D. ; Freudl, R. ; Thömmes, J. ; Kula, M.R. ; Takors, R. ; u. a.: Fed-Batch Production of recombinant human calcitonin precursor fusion-protein using Staphylococcus carnosus as expression-sectretion system. In: Appl. Microbiol. Biotechnol. Bd. 54 (2000), S. 361–369

  25. 1999

    1. 2.
      Schaefer, U ; Boos, W ; Takors, R ; Weuster-Botz, D: Automated sampling device for monitoring intracellular metabolite dynamics. In: Analytical biochemistry Bd. 270, Elsevier (1999), S. 88–96

  26. 1997

    1. 1.
      Takors, R ; Wiechert, W ; Weuster-Botz, D: Experimental design for the identification of macrokinetic models and model discrimination. In: Biotechnology and bioengineering Bd. 56, Wiley Subscription Services, Inc., A Wiley Company (1997), S. 564–576

Member of educational programs at University of Stuttgart: Technical Biology, (Bio-) Chemical Engineering, Technical Kybernetics, Environmental Engineering:

  • Biochemical Engineering (6 ECTS, undergraduate course), summer and winter term
  • Metabolic engineering (3 ECTS, graduate course), winter term
  • Bioreaction engineering (3 ECTS graduate course), summer term
  • Downstream processing (3 ECTS graduate course), winter term
  • Multiple Practical Courses for undergraduates and graduates

Other Teaching activities:

  • since 2014: Lecturer at TU Delft, Advanced course ‘Microbial Physiology and Fermentation’, Delft, The Netherland
  • 2016: Lecturer at TU Delft, Advanced Course ‘Genomics in Industrial Biotechnology, Delft, The Netherlands
  • 2016: Key closing lecture: European Summer School on Industrial Biotechnology, Barcelona, Spain
  • 2014: Lecturer German/Sino Graduate School, University of Hamburg-Harburg, Germany
  • 2012: Lecturer at Braunwald Course ‘Biosystems Engineering’, Braunwald Switzerland
  • 2011: Lecturer: Workshop ‘Synthetic Biology’, Basel, Switzerland
  • 2011: Lecturer: Scale-up and Technology Transfer, Sanofi-Aventis, Frankfurt, Germany

Since 01.07.2009

Director of the Institute of Biochemical Engineering (Institut für Bioverfahrenstechnik, IBVT), University of Stuttgart http://www.ibvt.uni-stuttgart.de 

2004-2009

Evonik Degussa GmbH, business unit Health & Nutrition; responsible for bioprocess development from lab to production scale, systems metabolic engineering 

1997-2004

Professorial dissertation (Habilitation); Institut für Biotechnologie, Forschungszentrum Jülich GmbH / RWTH Aachen

Metabolic and Bioprocess Engineering – A Fruitful Symbiosis

Venia Legendi: Metabolic Engineering 

1993-1997

Dissertation Biochemical Engineering (Dr. degree), Institut für Biotechnologie, Forschungszentrum Jülich GmbH / RWTH Aachen 

1987-1993

Diploma: Mechanical and Process Engineering, RWTH Aachen, Germany 

22.12.1966

Born in Koblenz, Germany, married, two children
 
 

  Journals
  • since 2019: Co-Editor-in-Chief of Engineering in Life Science
  • since 2017: member of the editorial board microbial biotechnology
  • since 2013: member of the editorial advisory board Bioprocess and Biosystems Engineering
  • since 2012: member of the editorial board Engineering in Life Science
 

Panels

  • since 2020: member of the division board 'Microbial Biotechnology' of EFB (European Federation of Biotechnology)
  • since 10/2020: appointed member of the advisory committee 'Bioeconomy' of the state Baden-Württemberg
  • since 2019: appointed member of the Board of Trustees, Fraunhofer Institute: IGB, Stuttgart
  • since 10/2014: Co-Head of the German Biochemical Engineering Section at DECHEMA e.V.  (http://www.dechema.de/Bioprozesstechnik.html)
  • since 10/2009: member of the Board of the Stuttgart Centre of Systems Biology, University of Stuttgart
  • at University of Stuttgart: multifold member of recruitment panels and steady member of educational training committees
  • multifold memberships in external recruiting and evaluation panels
  • multifold consultancy activities

2021

Elected to acatech, National Academy of Science and Engineering

2001

DECHEMA (Young-Professor Award) Hochschullehrer-Nachwuchspreis

15

Takors R. 2021. Kommentierte Formelsammlung Bioprozesstechnik. 2. Auflage, Springer Verlag.

14

Sarkizi Shams Hajian C., Zieringer J., Takors R. 2020.Euler-Lagrangian Simulations: A Proper Tool for Predicting Cellular Performance in Industrial Scale Bioreactors. In: Adv Biochem Eng Biotechnol. Eds.: Herwig C., Pörtner R., Möller J. https://doi.org/10.1007/10_2020_133.

13

Ziegler M., Takors R. 2020. Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis In: Minimal Cells: Design, Construction, Biotechnological Application: Eds: Lara AR, Gosset G. Springer Nature Switzerland, https://doi.org/10.1007/978-3-030-31897-0_1.

12

Chmiel H., Takors R., Weuster-Botz D. 2018. Bioprozesstechnik. 4th edition (completely updated and newly structured) ISBN 978-3-8274-2476-1 (in press)

11

Pfizenmaier J., Takors, R. 2016. Host organisms: Mammalian Cells, In: 'Industrial Biotechnology', edited by James Liao and Christoph Wittmann. Wiley-VCH series edited by Sang Yup Lee, Jens Nielsen and Gregory Stephanopoulos (accepted)

10

Takors R. 2014. Kommentierte Formelsammlung Bioverfahrenstechnik, Springer Spektrum. ISBN 978-3-642-41903-4.

9

Takors R. 2013. Bioverfahrenstechnik. In: Industrielle Mikrobiologie (Eds. Sahm H, Antranikian G, Stahmann P, Takors R), 1st edition, Springer Spektrum. ISBN 978-3-8274-3039-7.

8

Takors R. 2010. Systembiologie in der Bioverfahrenstechnik. In: Bioprozesstechnik (Ed. Chmiel), 3rd edition, Springer Spektrum. ISBN 978-3-8274-2476-1.

7

Oldiges M, Takors* R. 2005. Applying Metabolic Profiling Techniques for Stimulus-Response Experiments: Chances and Pitfalls, Adv. Biochem. Eng./Biotechnol. 92:173-196.

6

Wiechert* W, Takors R. 2003. Validation of Metabolic Models: Concepts, Tools and Problems, 277 – 320, In: Metabolic Engineering in a Post Genomic Era (Eds.: H.V. Westerhoff, B.N. Kholodenko) Horizon Scientific Press, ISBN 0-9545232-2-9.

5

Haunschild* MD, Freisleben B, Wiechert W, Takors R. 2002. Distributed Simulation of Metabolic Networks. In: Modelling and Simulation 2002, 436-440. SCS Europe. ISBN: 90-77039-07-4., 16 th European Simulation Multiconference ESM’2002, Darmstadt, 03.-05.06. Conference Proceedings.

4

Degenring D, Takors R. 2002. In vivo investigation of metabolic dynamics in Escherichia coli K12 by evaluation of Rapid Sampling Experiments, Proceedings of 5 th German Workshop on Artificial Life, Lübeck, ISBN 3-89838-030-0, IOS Press.

3

Takors* R, Gerigk M, Maass D, Bongaerts J, Schmidt K, Sprenger G, Wubbolts M, Wandrey C. 2001. Fed-batch Fermentation with Integrated Reactive-Extraction for L-Phenylalanine Production, Proceedings of 8 th Int. Con. Comp. Appl. in Biotechnol. CAB8, 24.-27.06.2001, Quebec, Canada, pp 189-194, ISBN 0-08-043681-1.

2

Takors* R, Weuster-Botz D, Wiechert W, Wandrey C. 2001. A model discriminating approach for data analysis and experimental design. Focus on Biotechnology, Vol. IV:   111-128, Eds. M. Hofman and P. Thonart, ISBN 0-7923-6927-0.

1

Takors* R, Weuster-Botz D, Wiechert W, Wandrey C. 1998. Model discrimination and parameter identification by an experimental design strategy, IFAC Proceeding Volumes: Computer Applications in Biotechnology. Pergamon Press. ISBN 0-08-043051-1.

14

Wiranata Wijaya A., Co invntors, Takors R. US patent application.

13

Ziegler M., Löffler, M., Simen J., Takors R. US patent application.

12

Michalowski, A., Siemann-Herzberg, M. Takors, R. 2017. Bacterial strain and method for high throughput of sugar in the microbial conversion into biosynthetic products. WO2017/186327 A1 

11

Takors, R., Tesch, M., Brandt, H.-J., Wandrey, C. 2004. Verfahren und Vorrichtung zur Begasung von Weinen, Deutsche Patentanmeldung DE 199 38 226.3 (August 1999), EP 1083221 granted 24.03.04. 

10

Bott, M., Gerharz, T., Zelic, B., Takors. R. 2002. Verfahren sowie Mikroorganismen zur mikrobiellen Herstellung von Pyruvat aus Kohlenhydraten sowie Alkoholen, DE 102 20 234.6, 06.05. 2002 

9

Rüffer, N., Wandrey, C., Takors, R. 2002. Integrierte Abtrennung organischer Substanzen aus einem wässrigen Bioprozessgemisch, DE 10220235.4-43 (06.05.02). 

8

Gerigk, M., Raeven, L., Sprenger, G., Takors, R. 2002. Process for the production of aromatic amino acid metabolites or derivatives thereof, (December 2001), EP 02078876.6 17.09.2002 

7

Gerharz, T., Bott, M., Zelic, B., Takors, R. 2001. Verfahren zur fermentativen Herstellung von Pyruvat, German patent application 101 29 711.4, 22.06. 2001 

6

El Massaoudi, M., Franz, A., de Graaf, A.A., Takors, R. 2001 Verfahren und Vorrichtung zur Untersuchung von Fermentationsprozessen, DE 101 20 839.1-41 (27.04.01) 

5

Müller M., Franke D., Müller, R., Thömmes, J.,Halfar, M., Sprenger, G., Takors, R., Lorbach, V. 2001. Herstellung von rekombinanten Mikroorganismen zur Produktion und Reingewinnung von Substanzen aus dem Aromaten-Biosyntheseweg und die Verwendung dieser in der Synthese biologisch wirksamer Substanzen, German patent application DE 100.42.535.6 (18.06.01) 

4

Buchholz, A., Takors, R., Wandrey, C. 2000. Verfahren zur Dosierung exakter Volumina von Flüssigkeiten in eine Vorlage sowie dafür geeignete Vorrichtung, Deutsche Patentanmeldung DE 100 03 416.0-52 (January 2000)

3

Gieren, H., Kula, M.-R., Rämsch, C., Selber, K., Thömmes, J., Halfar, M., Curvers, S., Takors, R., Weuster-Botz, D., Klauser, T. 1999. Verfahren zur Herstellung und Extraktion von Proteinen, German patent application DE 199 38 703.6-41 (August 1999)

2

Maaß, D., Takors, R., Paschold, H., Weuster-Botz, D., Wandrey, C. 2000. Verfahren zur Abtrennung organischer Substanzen aus einem wäßrigen Gemisch, German patent application DE 199 19 490.4-44 (April 1999, granted 18.04.2005), EP00/03705, WO 00/66253 (09.11.2000).

1

Schmitz, G., Weuster-Botz, D., Takors, R., Wandrey, C. 2002. Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen, German patent application 199 13 862.1-41 (März 1999), 05.11.2002.
  1. EmpowerPutida Project presentation, 2018 Movie
  2. Mit Fermentation das Klima retten, Deutschlandfunk, 2019 Radiointerview
  3. Der Studiengang Chemie- und Bioingenieurwesen CBIW 2020 https://www.uni-stuttgart.de/studium/bachelor/chemie-und-bioingenieurwesen-b.sc./studium/#id-a07a00cb
  4. Schwerpunktprogramm/DFG priority program SPP2170 'Interzell' https://www.ibvt.uni-stuttgart.de/work-areas/interzell/ 
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