Ralf Takors

Since 01.07.2009

Director of the Institute of Biochemical Engineering (Institut für Bioverfahrenstechnik, IBVT), University of Stuttgart http://www.ibvt.uni-stuttgart.de 

2004-2009

Evonik Degussa GmbH, business unit Health & Nutrition; responsible for bioprocess development from lab to production scale, systems metabolic engineering 

1997-2004

Professorial dissertation (Habilitation); Institut für Biotechnologie, Forschungszentrum Jülich GmbH / RWTH Aachen

Metabolic and Bioprocess Engineering – A Fruitful Symbiosis

Venia Legendi: Metabolic Engineering 

1993-1997

Dissertation Biochemical Engineering (Dr. degree), Institut für Biotechnologie, Forschungszentrum Jülich GmbH / RWTH Aachen 

1987-1993

Diploma: Mechanical and Process Engineering, RWTH Aachen, Germany 

22.12.1966

Born in Koblenz, Germany, married, two children

  Journals

• since 2019: Co-Editor-in-Chief of Engineering in Life Science
• since 2017: member of the editorial board microbial biotechnology
• since 2013: member of the editorial advisory board Bioprocess and Biosystems Engineering
• since 2012: member of the editorial board Engineering in Life Science

Panels

• since 2020: member of the division board 'Microbial Biotechnology' of EFB (European Federation of Biotechnology)
• since 10/2020: appointed member of the advisory committee 'Bioeconomy' of the state Baden-Württemberg
• since 2019: appointed member of the Board of Trustees, Fraunhofer Institute: IGB, Stuttgart
• since 10/2014: Co-Head of the German Biochemical Engineering Section at DECHEMA e.V.  (http://www.dechema.de/Bioprozesstechnik.html)
• since 10/2009: member of the Board of the Stuttgart Centre of Systems Biology, University of Stuttgart
• at University of Stuttgart: multifold member of recruitment panels and steady member of educational training committees
• multifold memberships in external recruiting and evaluation panels
• multifold consultancy activities

2021

Elected to acatech, National Academy of Science and Engineering

2001

DECHEMA (Young-Professor Award) Hochschullehrer-Nachwuchspreis

15

Takors R. 2021. Kommentierte Formelsammlung Bioprozesstechnik. 2. Auflage, Springer Verlag.

14

Sarkizi Shams Hajian C., Zieringer J., Takors R. 2020.Euler-Lagrangian Simulations: A Proper Tool for Predicting Cellular Performance in Industrial Scale Bioreactors. In: Adv Biochem Eng Biotechnol. Eds.: Herwig C., Pörtner R., Möller J. https://doi.org/10.1007/10_2020_133.

13

Ziegler M., Takors R. 2020. Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis In: Minimal Cells: Design, Construction, Biotechnological Application: Eds: Lara AR, Gosset G. Springer Nature Switzerland, https://doi.org/10.1007/978-3-030-31897-0_1.

12

Chmiel H., Takors R., Weuster-Botz D. 2018. Bioprozesstechnik. 4th edition (completely updated and newly structured) ISBN 978-3-8274-2476-1 (in press)

11

Pfizenmaier J., Takors, R. 2016. Host organisms: Mammalian Cells, In: 'Industrial Biotechnology', edited by James Liao and Christoph Wittmann. Wiley-VCH series edited by Sang Yup Lee, Jens Nielsen and Gregory Stephanopoulos (accepted)

10

Takors R. 2014. Kommentierte Formelsammlung Bioverfahrenstechnik, Springer Spektrum. ISBN 978-3-642-41903-4.

9

Takors R. 2013. Bioverfahrenstechnik. In: Industrielle Mikrobiologie (Eds. Sahm H, Antranikian G, Stahmann P, Takors R), 1st edition, Springer Spektrum. ISBN 978-3-8274-3039-7.

8

Takors R. 2010. Systembiologie in der Bioverfahrenstechnik. In: Bioprozesstechnik (Ed. Chmiel), 3rd edition, Springer Spektrum. ISBN 978-3-8274-2476-1.

7

Oldiges M, Takors* R. 2005. Applying Metabolic Profiling Techniques for Stimulus-Response Experiments: Chances and Pitfalls, Adv. Biochem. Eng./Biotechnol. 92:173-196.

6

Wiechert* W, Takors R. 2003. Validation of Metabolic Models: Concepts, Tools and Problems, 277 – 320, In: Metabolic Engineering in a Post Genomic Era (Eds.: H.V. Westerhoff, B.N. Kholodenko) Horizon Scientific Press, ISBN 0-9545232-2-9.

5

Haunschild* MD, Freisleben B, Wiechert W, Takors R. 2002. Distributed Simulation of Metabolic Networks. In: Modelling and Simulation 2002, 436-440. SCS Europe. ISBN: 90-77039-07-4., 16 ^th European Simulation Multiconference ESM’2002, Darmstadt, 03.-05.06. Conference Proceedings.

4

Degenring D, Takors R. 2002. In vivo investigation of metabolic dynamics in Escherichia coli K12 by evaluation of Rapid Sampling Experiments, Proceedings of 5 ^th German Workshop on Artificial Life, Lübeck, ISBN 3-89838-030-0, IOS Press.

3

Takors* R, Gerigk M, Maass D, Bongaerts J, Schmidt K, Sprenger G, Wubbolts M, Wandrey C. 2001. Fed-batch Fermentation with Integrated Reactive-Extraction for L-Phenylalanine Production, Proceedings of 8 ^th Int. Con. Comp. Appl. in Biotechnol. CAB8, 24.-27.06.2001, Quebec, Canada, pp 189-194, ISBN 0-08-043681-1.

2

Takors* R, Weuster-Botz D, Wiechert W, Wandrey C. 2001. A model discriminating approach for data analysis and experimental design. Focus on Biotechnology, Vol. IV:   111-128, Eds. M. Hofman and P. Thonart, ISBN 0-7923-6927-0.

1

Takors* R, Weuster-Botz D, Wiechert W, Wandrey C. 1998. Model discrimination and parameter identification by an experimental design strategy, IFAC Proceeding Volumes: Computer Applications in Biotechnology. Pergamon Press. ISBN 0-08-043051-1.

14

Wiranata Wijaya A., Co invntors, Takors R. US patent application.

13

Ziegler M., Löffler, M., Simen J., Takors R. US patent application.

12

Michalowski, A., Siemann-Herzberg, M. Takors, R. 2017. Bacterial strain and method for high throughput of sugar in the microbial conversion into biosynthetic products. WO2017/186327 A1 

11

Takors, R., Tesch, M., Brandt, H.-J., Wandrey, C. 2004. Verfahren und Vorrichtung zur Begasung von Weinen, Deutsche Patentanmeldung DE 199 38 226.3 (August 1999), EP 1083221 granted 24.03.04. 

10

Bott, M., Gerharz, T., Zelic, B., Takors. R. 2002. Verfahren sowie Mikroorganismen zur mikrobiellen Herstellung von Pyruvat aus Kohlenhydraten sowie Alkoholen, DE 102 20 234.6, 06.05. 2002 

9

Rüffer, N., Wandrey, C., Takors, R. 2002. Integrierte Abtrennung organischer Substanzen aus einem wässrigen Bioprozessgemisch, DE 10220235.4-43 (06.05.02). 

8

Gerigk, M., Raeven, L., Sprenger, G., Takors, R. 2002. Process for the production of aromatic amino acid metabolites or derivatives thereof, (December 2001), EP 02078876.6 17.09.2002 

7

Gerharz, T., Bott, M., Zelic, B., Takors, R. 2001. Verfahren zur fermentativen Herstellung von Pyruvat, German patent application 101 29 711.4, 22.06. 2001 

6

El Massaoudi, M., Franz, A., de Graaf, A.A., Takors, R. 2001 Verfahren und Vorrichtung zur Untersuchung von Fermentationsprozessen, DE 101 20 839.1-41 (27.04.01) 

5

Müller M., Franke D., Müller, R., Thömmes, J.,Halfar, M., Sprenger, G., Takors, R., Lorbach, V. 2001. Herstellung von rekombinanten Mikroorganismen zur Produktion und Reingewinnung von Substanzen aus dem Aromaten-Biosyntheseweg und die Verwendung dieser in der Synthese biologisch wirksamer Substanzen, German patent application DE 100.42.535.6 (18.06.01) 

4

Buchholz, A., Takors, R., Wandrey, C. 2000. Verfahren zur Dosierung exakter Volumina von Flüssigkeiten in eine Vorlage sowie dafür geeignete Vorrichtung, Deutsche Patentanmeldung DE 100 03 416.0-52 (January 2000)

3

Gieren, H., Kula, M.-R., Rämsch, C., Selber, K., Thömmes, J., Halfar, M., Curvers, S., Takors, R., Weuster-Botz, D., Klauser, T. 1999. Verfahren zur Herstellung und Extraktion von Proteinen, German patent application DE 199 38 703.6-41 (August 1999)

2

Maaß, D., Takors, R., Paschold, H., Weuster-Botz, D., Wandrey, C. 2000. Verfahren zur Abtrennung organischer Substanzen aus einem wäßrigen Gemisch, German patent application DE 199 19 490.4-44 (April 1999, granted 18.04.2005), EP00/03705, WO 00/66253 (09.11.2000).

1

Schmitz, G., Weuster-Botz, D., Takors, R., Wandrey, C. 2002. Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen, German patent application 199 13 862.1-41 (März 1999), 05.11.2002.